Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)

Öz:

Amaç: Hiperkolesterolemi tanısı ile izlenen statin kullanmakta olan hastalarda statin tedavisinin kesilmesi ile ilişkili hasta özellikleri ve sorumlu faktörlerin belirlenmesi.Yöntemler: Bu ulusal müdahalesiz gözlem çalışmasına statin tedavisini bırakmış toplam 532 (ort. yaş±SS 57.4±11.5 yıl; %52.4 kadın, %47.6 erkek) hiperkolesterolemili hasta dahil edildi. Hastaların sosyodemografik özellikleri kardiyovasküler risk faktörleri, geçmiş statin tedavisi ve tedavinin kesilmesine yönelik veriler tek vizitte kaydedildi.Bulgular: Hastalara statin tedavisini bıraktıklarında ort.±SS 4.9±4.2 yıldı, hiperkolesterolemi tanısı konulmuş olduğu tespit edildi. Statin tedavisi hekim grupları içinde en sık kardiyologlar (%55.8) tarafından başlatılırken, tedaviyi bırakma kararının büyük çoğunlukla hastalar (%73.7) tarafından alındığı; hastanın bu kararı kendi insiyatifinde almasının daha yüksek eğitim düzeylerinde (%80.4), düşük eğitim düzeylerine (%69.7) göre belirgin olarak daha yaygın (p=0.022) olduğu saptandı. TV programlarında statin hakkında yapılan olumsuz haberler (%32.9); ilacın hepatik (%38.0), renal (%33.8) ve musküler (%32.9) yan etkilerinden çekinilmesi statin tedavisinin bırakılması ile ilişkili en sık oranda saptanan faktörler idi.Sonuç: Sonuç olarak, bu müdahalesiz gözlemsel çalışmada, statin tedavisinin %74 oranda hastaların kendi kendine ilacı bırakma kararı doğrultusunda gerçekleştiği saptanmıştır. Tedavi bırakma ve ilaç dışı alternatif tedavilere yönelme kararının daha yüksek eğitim düzeyine sahip hastalarca daha sıklıkla alındığı görülmüştür. Statin tedavisinin en sık kardiyologlar tarafından başlatıldığı ve TV programlarında statin hakkında özellikle ilacın yaşamı tehdit etmeyen yan etkilerine yönelik yapılan olumsuz haberlerin yanı sıra, hastaların hiperkolesterolemi ve ilgili riskleri konusunda yeterli bilgi düzeyinden yoksun olmalarının statin tedavisinin bırakılmasında öne çıkan sorumlu faktörler olduğu anlaşılmaktadır

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APA	Tokgozoglu L, ÖZDEMİR R, CEYHAN C, YETER E, ÖZTÜRK C, bayram f, DELİBAŞI T, DEĞERTEKİN M, DİNÇKAL M, keleş i, Fak A, AYDOĞDU S, ZORKUN C, TARTAN Z (2016). Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). , 53 - 64.
Chicago	Tokgozoglu Lale,ÖZDEMİR Ramazan,CEYHAN Ceyhun,YETER Ekrem,ÖZTÜRK CİHAN,bayram fahri,DELİBAŞI Tuncay,DEĞERTEKİN Muzaffer,DİNÇKAL Mustafa Hakan,keleş ibrahim,Fak Ali Serdar,AYDOĞDU Sinan,ZORKUN Cafer,TARTAN Zeynep Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). (2016): 53 - 64.
MLA	Tokgozoglu Lale,ÖZDEMİR Ramazan,CEYHAN Ceyhun,YETER Ekrem,ÖZTÜRK CİHAN,bayram fahri,DELİBAŞI Tuncay,DEĞERTEKİN Muzaffer,DİNÇKAL Mustafa Hakan,keleş ibrahim,Fak Ali Serdar,AYDOĞDU Sinan,ZORKUN Cafer,TARTAN Zeynep Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). , 2016, ss.53 - 64.
AMA	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). . 2016; 53 - 64.
Vancouver	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). . 2016; 53 - 64.
IEEE	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z "Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)." , ss.53 - 64, 2016.
ISNAD	Tokgozoglu, Lale vd. "Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)". (2016), 53-64.

APA	Tokgozoglu L, ÖZDEMİR R, CEYHAN C, YETER E, ÖZTÜRK C, bayram f, DELİBAŞI T, DEĞERTEKİN M, DİNÇKAL M, keleş i, Fak A, AYDOĞDU S, ZORKUN C, TARTAN Z (2016). Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Türk Kardiyoloji Derneği Arşivi, 44(1), 53 - 64.
Chicago	Tokgozoglu Lale,ÖZDEMİR Ramazan,CEYHAN Ceyhun,YETER Ekrem,ÖZTÜRK CİHAN,bayram fahri,DELİBAŞI Tuncay,DEĞERTEKİN Muzaffer,DİNÇKAL Mustafa Hakan,keleş ibrahim,Fak Ali Serdar,AYDOĞDU Sinan,ZORKUN Cafer,TARTAN Zeynep Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Türk Kardiyoloji Derneği Arşivi 44, no.1 (2016): 53 - 64.
MLA	Tokgozoglu Lale,ÖZDEMİR Ramazan,CEYHAN Ceyhun,YETER Ekrem,ÖZTÜRK CİHAN,bayram fahri,DELİBAŞI Tuncay,DEĞERTEKİN Muzaffer,DİNÇKAL Mustafa Hakan,keleş ibrahim,Fak Ali Serdar,AYDOĞDU Sinan,ZORKUN Cafer,TARTAN Zeynep Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Türk Kardiyoloji Derneği Arşivi, vol.44, no.1, 2016, ss.53 - 64.
AMA	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Türk Kardiyoloji Derneği Arşivi. 2016; 44(1): 53 - 64.
Vancouver	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study). Türk Kardiyoloji Derneği Arşivi. 2016; 44(1): 53 - 64.
IEEE	Tokgozoglu L,ÖZDEMİR R,CEYHAN C,YETER E,ÖZTÜRK C,bayram f,DELİBAŞI T,DEĞERTEKİN M,DİNÇKAL M,keleş i,Fak A,AYDOĞDU S,ZORKUN C,TARTAN Z "Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)." Türk Kardiyoloji Derneği Arşivi, 44, ss.53 - 64, 2016.
ISNAD	Tokgozoglu, Lale vd. "Patient characteristics and statin discontinuation-related factors during treatment of hypercholesterolemia: an observational non-interventional study in patients with statin discontinuation (STAY study)". Türk Kardiyoloji Derneği Arşivi 44/1 (2016), 53-64.