Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases
Yıl: 2016 Cilt: 22 Sayı: 2 Sayfa Aralığı: 155 - 162 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases
Öz: AMAÇ: Bu çalışmada ameliyat öncesi lökosit (WCC), nötrofil/lenfosit oranı (NLR), trombosit (PLT), ortalama-trombosit-hacmi (MPV) ve serum bilirubin düzeyleri gibi basit laboratuvar incelemelerinin akut apandisit tanısı koymakta veya perfore olguların basit apandisitlerden ayırmını yapmaktaki etkinliğini ortaya koymayı amaçladık. GEREÇ VE YÖNTEM: Apendektomi ameliyatı uygulanmış 3392 hasta geriye dönük olarak değerlendirildi. Hastalar histopatolojik tanılarına göre öncelikle iki gruba ayrıldı. Normal appendiks bulguları olan olgular (Grup 1) ve akut apandisit olan olgular (Grup 2). Daha sonra ikinci gruptaki olgular basit akut apandisit olguları (Grup 2A) ve perfore apandisit olguları (Grup 2B) olarak alt gruplara ayrıldı. Gruplar arasında ameliyat öncesi WCC, NLR, PLT, MPV ve serum bilirubin düzeyleri karşılaştırıldı. Önce univariate analiz ile bağımsız değişkenler saptandı, daha sonra bunlardan çok değişkenli analizde p değeri 0.05'den küçük olanlara ROC eğrisi analizi uygulandı. Eğrinin altında kalan alan 0.600'den büyük olan parametreler anlamlı paremtetre olarak kabul edilerek eşik değer hesaplandı. BULGULAR: WCC, bilirubin ve NLR, akut apandisit tanısında klinik kullanımda anlamlı parametreler olarak saptandı. Lökositoz için eşik değer 11.900/mm3 (sensitivite %71.2, spesifisite %67.2, OR: 5.13), bilirubin için 1.0 mg/dl (sensitivite %19.1, spesifisite %92.4, OR: 2.96) ve NLR için 3.0 (sensitivite %81.2, spesifisite %53.1, OR: 4.27) idi. Bilirubin ve NLR, perfore apandisit olgularının ayırımında anlamlı parametrelerdi. Bilirubin için eşik değer 1.0 mg/dl (sensitivite %78.4, spesifisite %41.7, OR: 2.6) ve NLR için 4.8 (sensitivite %81.2, spesifisite %53.1, OR: 2.6) idi. TARTIŞMA: Akut apandisit şüphesi oluşturan bulgularla gelen bir olguda serum lökosit değerinin 11.900/mm3 'den, bilirubin değerinin 1.0 mg/ dl'den, veya nötrofil/lenfosit oranının 3.0'den fazla olması akut apandisit tanısı destekler. Akut apandisit düşünülen bir olguda ise bilirubin değerinin 1.0 mg/dl'den veya nötrofil/lenfosit oranının 4.8'den büyük olması olguda perforasyon geliştiğini destekler verilerdir. WCC, akut apandisit tanısında anlamlı olmasına rağmen, perfore olguların tanınmasında güçlü bir parametre değildir. PLT ve MPV akut apandisit şüpheli olgularda tanısal anlam taşımamaktadırlar
Anahtar Kelime: Konular:
Basit ve perfore apandisitlerde temel laboratuvar testlerinin tanısal değeri: 3392 olgu analizi
Öz: BACKGROUND: The aim of the present study was to examine the efficacy of simple laboratory parameters including neutrophilto-lymphocyte ratio (NLR), platelet count (PLT), mean platelet volume (MPV), and serum bilirubin level in the diagnosis of acute appendicitis and recognition of perforated appendicitis.METHODS: Records of 3392 patients who underwent appendectomy in a 10-year period were reviewed retrospectively. Patients were divided into 2 groups according to histopathological examination results: Group 1 had normal appendix, Group 2 had acute appendicitis. Patients with acute appendicitis were divided into subgroups: Group 2A had simple acute appendicitis, while Group 2B had perforated appendicitis. Efficacy of the aforementioned laboratory parameters was evaluated in the diagnosis of acute appendicitis and recognition of perforated appendicitis. Independent variables were determined by univariate analysis and multivariate analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to identify significant parameters in multivariate analysis. Cut-off values, sensitivity, specificity, and accuracy calculations performed for parameters with area under curve (AUC) >0.600 were
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Sevinc M, KINACI E, çakar e, BAYRAK S, ÖZAKAY A, Aren A, SARI S (2016). Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. , 155 - 162. |
| Chicago | Sevinc Mert Mahsuni,KINACI Erdem,çakar ekrem,BAYRAK Savaş,ÖZAKAY Abdulkerim,Aren Acar,SARI Serkan Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. (2016): 155 - 162. |
| MLA | Sevinc Mert Mahsuni,KINACI Erdem,çakar ekrem,BAYRAK Savaş,ÖZAKAY Abdulkerim,Aren Acar,SARI Serkan Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. , 2016, ss.155 - 162. |
| AMA | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. . 2016; 155 - 162. |
| Vancouver | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. . 2016; 155 - 162. |
| IEEE | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S "Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases." , ss.155 - 162, 2016. |
| ISNAD | Sevinc, Mert Mahsuni vd. "Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases". (2016), 155-162. |
| APA | Sevinc M, KINACI E, çakar e, BAYRAK S, ÖZAKAY A, Aren A, SARI S (2016). Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. Ulusal Travma ve Acil Cerrahi Dergisi, 22(2), 155 - 162. |
| Chicago | Sevinc Mert Mahsuni,KINACI Erdem,çakar ekrem,BAYRAK Savaş,ÖZAKAY Abdulkerim,Aren Acar,SARI Serkan Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. Ulusal Travma ve Acil Cerrahi Dergisi 22, no.2 (2016): 155 - 162. |
| MLA | Sevinc Mert Mahsuni,KINACI Erdem,çakar ekrem,BAYRAK Savaş,ÖZAKAY Abdulkerim,Aren Acar,SARI Serkan Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. Ulusal Travma ve Acil Cerrahi Dergisi, vol.22, no.2, 2016, ss.155 - 162. |
| AMA | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. Ulusal Travma ve Acil Cerrahi Dergisi. 2016; 22(2): 155 - 162. |
| Vancouver | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases. Ulusal Travma ve Acil Cerrahi Dergisi. 2016; 22(2): 155 - 162. |
| IEEE | Sevinc M,KINACI E,çakar e,BAYRAK S,ÖZAKAY A,Aren A,SARI S "Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases." Ulusal Travma ve Acil Cerrahi Dergisi, 22, ss.155 - 162, 2016. |
| ISNAD | Sevinc, Mert Mahsuni vd. "Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis: an analysis of 3392 cases". Ulusal Travma ve Acil Cerrahi Dergisi 22/2 (2016), 155-162. |
