Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation
Yıl: 2016 Cilt: 33 Sayı: 2 Sayfa Aralığı: 144 - 151 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation
Öz: Background: Calcium homeostasis is considered to be important in antineoplastic as well as in neurotoxic adverse effects of cisplatin. Aims: This study aimed to investigate the role of Ca2+ in cisplatin neurotoxicity in cultured rat dorsal root ganglia (DRG) cells. Study Design: Cell culture study. Methods: DRG cells prepared from 1-day old SpragueDawley rats were used to determine the role of Ca2+ in the cisplatin (10-600 ?M) neurotoxicity. The cells were incubated with cisplatin plus nimodipine (1-3 ?M), dizocilpine (MK-801) (1-3 ?M) or thapsigargin (100- 300 nM). Toxicity of cisplatinon DRG cells was determined by the MTT assay. Results: The neurotoxicity of cisplatin was significant when used in high concentrations (100-600 ?M). Nimodipine (1 ?M) but not MK-801 or thapsigargin prevented the neurotoxic effects of 200 ?M of cisplatin. Conclusion: Voltage-dependent calcium channels may play a role in cisplatin neurotoxicity.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Windebank AJ, Grisold W. Chemotherapy-induced neuropa- thy. J Peripher Nerv Syst 2008;13:27-46. [CrossRef]
- Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemo- therapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 2008;44:1507-15. [CrossRef]
- von Schlippe M, Fowler CJ, Harland SJ. Cisplatin neurotoxic- ity in the treatment of metastatic germ cell tumour: time course and prognosis. Br J Cancer 2001;85:823-6. [CrossRef]
- Wu F, Lin X, Okuda T, Howell SB. DNA polymerase zeta reg- ulates cisplatin cytotoxicity, mutagenicity, and the rate of de- velopment of cisplatin resistance. Cancer Res 2004;64:8029- 35. [CrossRef]
- McDonald ES, Randon KR, Knight A, Windebank AJ. Cispla- tin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity. Neurobiol Dis 2005;18:305-13. [CrossRef]
- Ocean AJ, Vahdat LT. Chemotherapy-induced peripheral neu- ropathy: pathogenesis and emerging therapies. Support Care Cancer 2004;12:619-25. [CrossRef]
- Gill JS, Windebank AJ. Cisplatin-induced apoptosis in rat dor- sal root ganglion neurons is associated with attempted entry into the cell cycle. J Clin Invest 1998;101:2842-50. [CrossRef]
- Cavaletti G, Minoia C, Schieppati M, Tredici G. Protective effects of glutathione on cisplatin neurotoxicity in rats. Int J Radiat Oncol Biol Phys 1994;29:771-6. [CrossRef]
- Capizzi RL. Protection of normal tissues from the cytotoxic effects of chemotherapy by amifostine (Ethyol): clinical expe- riences. Semin Oncol 1994;21:8-15.
- Hol EM, Gispen WH, Bar PR. ACTH-related peptides: recep- tors and signal transduction systems involved in their neuro- trophic and neuroprotective actions. Peptides 1995;16:979- 93. [CrossRef]
- Konings PN, Makkink WK, van Delft AM, Ruigt GS. Re- versal by NGF of cytostatic drug-induced reduction of neu- rite outgrowth in rat dorsal root ganglia in vitro. Brain Res 1994;640:195-204. [CrossRef]
- McKeage MJ, Haddad GG, Ding L, Galettis P, Screnci D, Zhuang L, et al. Neuroprotective interactions in rats between paclitaxel and cisplatin. Oncol Res 1999;11:287-93.
- Screnci D, McKeage MJ. Platinum neurotoxicity: clinical pro- files, experimental models and neuroprotective approaches. Jour- nal of inorganic biochemistry. 1999;77:105-10. [CrossRef]
- Piccolini VM, Bottone MG, Bottiroli G, De Pascali SA, Fanizzi FP, Bernocchi G. Platinum drugs and neurotoxicity: effects on intracellular calcium homeostasis. Cell Biol Toxicol 2013;29:339-53. [CrossRef]
- Avan A, Postma TJ, Ceresa C, Avan A, Cavaletti G, Giovan- netti E, et al. Platinum-Induced Neurotoxicity and Preventive Strategies: Past, Present, and Future. Oncologist 2015;20:411- 32. [CrossRef]
- Cummings BS, Gelasco AK, Kinsey GR, McHowat J, Schnell- mann RG. Inactivation of endoplasmic reticulum bound Ca2+- independent phospholipase A2 in renal cells during oxidative stress. J Am Soc Nephrol 2004;15:1441-51. [CrossRef]
- Tomaszewski A, Busselberg D. Cisplatin modulates voltage gated channel currents of dorsal root ganglion neurons of rats. Neurotoxicology 2007;28:49-58. [CrossRef]
- Jaffe LF. A calcium-based theory of carcinogenesis. Advances in cancer research. 2005;94:231-63. [CrossRef]
- Kondo S, Yin D, Morimura T, Kubo H, Nakatsu S, Takeuchi J. Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells. Br J Cancer 1995;71:282-9. [CrossRef]
- Jong NN, Nakanishi T, Liu JJ, Tamai I, McKeage MJ. Oxali- platin transport mediated by organic cation/carnitine transport- ers OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. J Phar- macol Exp Ther 2011;338:537-47. [CrossRef]
- Ulupinar E, Erzurumlu RS. Peripheral target-specific influences on embryonic neurite growth vigor and patterns. J Comp Neurol 1998;399:427-39. [CrossRef]
- Leach MK, Feng ZQ, Gertz CC, Tuck SJ, Regan TM, Naim Y, et al. The culture of primary motor and sensory neurons in defined media on electrospun poly-L-lactide nanofiber scaffolds. J Vis Exp 2011. [CrossRef]
- Duzenli S, Bakuridze K, Gepdiremen A. The effects of rutheni- um red, dantrolene and nimodipine, alone or in combination, in NMDA induced neurotoxicity of cerebellar granular cell culture of rats. Toxicol In Vitro 2005;19:589-94. [CrossRef]
- Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 2004;3:71-6. [CrossRef]
- Mosmann T. Rapid colorimetric assay for cellular growth and sur- vival: application to proliferation and cytotoxicity assays. J Im- munol Methods 1983;65:55-63. [CrossRef]
- Scudiero DA, Shoemaker RH, Paull KD, Monks A, Tierney S, Nofziger TH, et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988;48:4827-33.
- Ta LE, Espeset L, Podratz J, Windebank AJ. Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons corre- lates with platinum-DNA binding. Neurotoxicology 2006;27:992- 1002. [CrossRef]
- Jaggi AS, Singh N. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology 2012;291:1-9. [CrossRef]
- Beijers AJ, Jongen JL, Vreugdenhil G. Chemotherapy-induced neurotoxicity: the value of neuroprotective strategies. Neths j med 2012;70:18-25.
- Amptoulach S, Tsavaris N. Neurotoxicity caused by the treatment with platinum analogues. Chemother Res Pract 2011;2011:843019. [CrossRef]
- Meara DJ, Johnson B, Wang Y, Aggarwal SK. Role of calcium in modulation of toxicities due to cisplatin and its analogs: a histo- chemical approach. Anticancer Drugs 1997;8:988-99. [CrossRef]
- Grolleau F, Gamelin L, Boisdron-Celle M, Lapied B, Pelhate M, Gamelin E. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol 2001;85:2293-7.
- Armstrong CM, Cota G. Calcium block of Na+ channels and its effect on closing rate. Proc Natl Acad Sci USA 1999;96:4154-7. [CrossRef]
- Melli G, Taiana M, Camozzi F, Triolo D, Podini P, Quattrini A, et al. Alpha-lipoic acid prevents mitochondrial damage and neu- rotoxicity in experimental chemotherapy neuropathy. Exp Neurol 2008;214:276-84. [CrossRef]
- Leinninger GM, Edwards JL, Lipshaw MJ, Feldman EL. Mechanisms of disease: mitochondria as new therapeutic tar- gets in diabetic neuropathy. Nat Clin Pract Neurol 2006;2:620- 8. [CrossRef]
- Shoichet SA, Baumer AT, Stamenkovic D, Sauer H, Pfeiffer AF, Kahn CR, et al. Frataxin promotes antioxidant defense in a thiol- dependent manner resulting in diminished malignant transforma- tion in vitro. Hum Mol Genet 2002;11:815-21. [CrossRef]
- Podratz JL, Knight AM, Ta LE, Staff NP, Gass JM, Genelin K, et al. Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiol Dis 2011;41:661-8. [CrossRef]
- Adelsberger H, Quasthoff S, Grosskreutz J, Lepier A, Eckel F, Lersch C. The chemotherapeutic oxaliplatin alters voltage- gated Na(+) channel kinetics on rat sensory neurons. Eur J Pharmacol 2000;406:25-32. [CrossRef]
- Egashira N, Hirakawa S, Kawashiri T, Yano T, Ikesue H, Oishi R. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci 2010;112:473-6. [CrossRef]
| APA | Erol K, YİĞİTASLAN S, ÇENGELLI ÜNEL Ç, KAYGISIZ B, YILDIRIM E (2016). Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. , 144 - 151. |
| Chicago | Erol Kevser,YİĞİTASLAN Semra,ÇENGELLI ÜNEL ÇIGDEM,KAYGISIZ Bilgin,YILDIRIM Engin Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. (2016): 144 - 151. |
| MLA | Erol Kevser,YİĞİTASLAN Semra,ÇENGELLI ÜNEL ÇIGDEM,KAYGISIZ Bilgin,YILDIRIM Engin Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. , 2016, ss.144 - 151. |
| AMA | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. . 2016; 144 - 151. |
| Vancouver | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. . 2016; 144 - 151. |
| IEEE | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E "Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation." , ss.144 - 151, 2016. |
| ISNAD | Erol, Kevser vd. "Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation". (2016), 144-151. |
| APA | Erol K, YİĞİTASLAN S, ÇENGELLI ÜNEL Ç, KAYGISIZ B, YILDIRIM E (2016). Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. Balkan Medical Journal, 33(2), 144 - 151. |
| Chicago | Erol Kevser,YİĞİTASLAN Semra,ÇENGELLI ÜNEL ÇIGDEM,KAYGISIZ Bilgin,YILDIRIM Engin Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. Balkan Medical Journal 33, no.2 (2016): 144 - 151. |
| MLA | Erol Kevser,YİĞİTASLAN Semra,ÇENGELLI ÜNEL ÇIGDEM,KAYGISIZ Bilgin,YILDIRIM Engin Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. Balkan Medical Journal, vol.33, no.2, 2016, ss.144 - 151. |
| AMA | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. Balkan Medical Journal. 2016; 33(2): 144 - 151. |
| Vancouver | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation. Balkan Medical Journal. 2016; 33(2): 144 - 151. |
| IEEE | Erol K,YİĞİTASLAN S,ÇENGELLI ÜNEL Ç,KAYGISIZ B,YILDIRIM E "Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation." Balkan Medical Journal, 33, ss.144 - 151, 2016. |
| ISNAD | Erol, Kevser vd. "Evaluation of Cisplatin Neurotoxicity in Cultured Rat Dorsal Root Ganglia via Cytosolic Calcium Accumulation". Balkan Medical Journal 33/2 (2016), 144-151. |
