Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group

Öz:

Amaç: Relaps/refrakter Hodgkin lenfomanın (HL) otolog hematopoetik kök hücre nakli (OHKHN) sonrasındaki prognozunu gösterecek belirteçler ve çocukluk çağında yeni bir prognostik skorlama araştırıldı. Gereç ve Yöntemler: Bu çalışmada, Ocak 1990-Aralık 2014 tarihleri arasında OHKHN uygulanan 61 hastanın OHKHN sonrası prognozunu etkileyen faktörlerin sağkalım üzerine etkisi araştırıldı. Aynı zamanda Yaşa Göre Düzeltilmiş Uluslararası Prognostik İndeks ve Çocukluk Dönemi Uluslararası Prognostik İndeks'lerinin (ÇDUPİ) prognoz üzerindeki etkisi değerlendirildi. Bulgular: Altmış bir hastanın ortanca yaşı OHKHN sırasında 14,8 yıl (5-20 yıl) idi. Hastalardan, 28 olguda bir relaps, 8 olguda >=2 relaps ve 25 olguda refrakter hastalık vardı. Kemosensitivite/kemoterapiye dirençlilik oranı 36/25 idi. Nakil öncesi radyoterapi almamak, nakil öncesi remisyonda olmamak, nakil sonrası beyaz kan hücresi sayısının10x103/µL üzerinde olması, nakil sonrası 100. gün pozitron emisyon tomografisi pozitifliği, tanıda 2,5 g/dL'den düşük serum albümin düzeyi progresyonsuz sağkalım üzerinde etkili belirteçler iken transplantasyon zamanı remisyonda olmamak, tanıda kemik iliği pozitifliği ve OHKHN sonrası relaps ise genel sağkalım üzerinde etkili parametreler olarak bulundu. Sonuç: Relaps/refrakter HL'li çocuklarda progresyonsuz ve genel sağkalımı etkileyen faktörler açıkça gösterildi. Serum laktat dehidrogenaz üst sınırını 500 IU/L olarak kullanan ÇDUPİ prognozu göstermede etkili bulundu. Relaps hastalarda ilk tam remisyonda OHKHN yapılmasını ve tanı anında yüksek prognostik skoru olan olguların da OHKHN açısından değerlendirmeye alınmasını önermekteyiz.

Anahtar Kelime:

Konular: Hematoloji

Otolog Hematopoetik Kök Hücre Nakli Uygulanmış Hodgkin Lenfomalı Çocuk ve Adölesanlarda Prognostik Faktörler ve Yeni Bir Prognostik İndeks Modeli: Türk Pediatrik Kemik İliği Nakli Çalışma Grubundan Çok Merkezli Çalışma

Öz:

transplantation, posttransplant white blood cell count over 10x103/µL, posttransplant positron emission tomography positivity at day 100, and serum albumin of <2.5 g/dL at diagnosis were correlated with progression-free survival. No remission at the time of transplantation, bone marrow positivity at diagnosis, and relapse after AHSCT were significant parameters for overall survival. Conclusion: The major factors affecting the progression-free and overall survival were clearly demonstrated. A CIPI that uses a lactate dehydrogenase level of 500 IU/L worked well for estimating the prognosis. We recommend AHSCT at first complete remission for relapsed cases, and it should also be taken into consideration for patients with high prognostic scores at diagnosis.

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KESİK V, Ataş E, Karakukcu M, aksoylar s, ERBEY F, TAÇYILDIZ N, Kupesiz O, Öniz H, UNAL E, KANSOY S, ÖZTÜRK G, ELLİ M, Kaya Z, ÜNAL E, Hazar V, YILMAZ BENGOA Ş, Karasu G, ATAY D, Dağdemir A, ÖREN H, Kocak U, YEŞİLİPEK M (2016). Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. , 265 - 272.
Chicago	KESİK Vural,Ataş Erman,Karakukcu Musa,aksoylar serap,ERBEY Fatih,TAÇYILDIZ Nurdan,Kupesiz Osman Alphan,Öniz Haldun,UNAL Ekrem,KANSOY Savaş,ÖZTÜRK Gülyüz,ELLİ Murat,Kaya Zuhre,ÜNAL Emel,Hazar Volkan,YILMAZ BENGOA Şebnem,Karasu Gulsun,ATAY Didem,Dağdemir Ayhan,ÖREN Hale,Kocak Ulker,YEŞİLİPEK M. Akif Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. (2016): 265 - 272.
MLA	KESİK Vural,Ataş Erman,Karakukcu Musa,aksoylar serap,ERBEY Fatih,TAÇYILDIZ Nurdan,Kupesiz Osman Alphan,Öniz Haldun,UNAL Ekrem,KANSOY Savaş,ÖZTÜRK Gülyüz,ELLİ Murat,Kaya Zuhre,ÜNAL Emel,Hazar Volkan,YILMAZ BENGOA Şebnem,Karasu Gulsun,ATAY Didem,Dağdemir Ayhan,ÖREN Hale,Kocak Ulker,YEŞİLİPEK M. Akif Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. , 2016, ss.265 - 272.
AMA	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. . 2016; 265 - 272.
Vancouver	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. . 2016; 265 - 272.
IEEE	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M "Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group." , ss.265 - 272, 2016.
ISNAD	KESİK, Vural vd. "Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group". (2016), 265-272.

APA	KESİK V, Ataş E, Karakukcu M, aksoylar s, ERBEY F, TAÇYILDIZ N, Kupesiz O, Öniz H, UNAL E, KANSOY S, ÖZTÜRK G, ELLİ M, Kaya Z, ÜNAL E, Hazar V, YILMAZ BENGOA Ş, Karasu G, ATAY D, Dağdemir A, ÖREN H, Kocak U, YEŞİLİPEK M (2016). Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. Turkish Journal of Hematology, 33(4), 265 - 272.
Chicago	KESİK Vural,Ataş Erman,Karakukcu Musa,aksoylar serap,ERBEY Fatih,TAÇYILDIZ Nurdan,Kupesiz Osman Alphan,Öniz Haldun,UNAL Ekrem,KANSOY Savaş,ÖZTÜRK Gülyüz,ELLİ Murat,Kaya Zuhre,ÜNAL Emel,Hazar Volkan,YILMAZ BENGOA Şebnem,Karasu Gulsun,ATAY Didem,Dağdemir Ayhan,ÖREN Hale,Kocak Ulker,YEŞİLİPEK M. Akif Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. Turkish Journal of Hematology 33, no.4 (2016): 265 - 272.
MLA	KESİK Vural,Ataş Erman,Karakukcu Musa,aksoylar serap,ERBEY Fatih,TAÇYILDIZ Nurdan,Kupesiz Osman Alphan,Öniz Haldun,UNAL Ekrem,KANSOY Savaş,ÖZTÜRK Gülyüz,ELLİ Murat,Kaya Zuhre,ÜNAL Emel,Hazar Volkan,YILMAZ BENGOA Şebnem,Karasu Gulsun,ATAY Didem,Dağdemir Ayhan,ÖREN Hale,Kocak Ulker,YEŞİLİPEK M. Akif Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. Turkish Journal of Hematology, vol.33, no.4, 2016, ss.265 - 272.
AMA	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. Turkish Journal of Hematology. 2016; 33(4): 265 - 272.
Vancouver	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group. Turkish Journal of Hematology. 2016; 33(4): 265 - 272.
IEEE	KESİK V,Ataş E,Karakukcu M,aksoylar s,ERBEY F,TAÇYILDIZ N,Kupesiz O,Öniz H,UNAL E,KANSOY S,ÖZTÜRK G,ELLİ M,Kaya Z,ÜNAL E,Hazar V,YILMAZ BENGOA Ş,Karasu G,ATAY D,Dağdemir A,ÖREN H,Kocak U,YEŞİLİPEK M "Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group." Turkish Journal of Hematology, 33, ss.265 - 272, 2016.
ISNAD	KESİK, Vural vd. "Prognostic Factors and a New Prognostic Index Model for Children and Adolescents with Hodgkin's Lymphoma Who Underwent Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Study of the Turkish Pediatric Bone Marrow Transplantation Study Group". Turkish Journal of Hematology 33/4 (2016), 265-272.