Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis

Izol, Volkan; ERDOĞAN, Şeyda; Seydaoglu, Gulsah; KILIÇ BAĞIR, EMİNE; A�IKALIN, ARBIL

Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis

Emine KILIÇ BAĞIR, (Çukurova Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Adana, Türkiye)

Arbil AÇIKALIN, (Çukurova Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Adana, Türkiye)

Volkan İZOL, (Çukurova Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Adana, Türkiye)

Gülşah ŞEYDAOĞLU, (Çukurova Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Adana, Türkiye)

Şeyda ERDOĞAN (Çukurova Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Adana, Türkiye)

Üroonkoloji Bülteni

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Yıl: 2016 Cilt: 15 Sayı: 4 Sayfa Aralığı: 144 - 147 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis

Öz:

Amaç: Prostat karsinomu (PK) önemli oranda ölümcül ve morbiditesi olan, sık görülen kanser türlerinden biridir. PK'nin etiyolojisi net değildir. Enflamatuvar yolaktaki sitokin ve mediatörler; kronik enflamasyon ve kanser arasındaki ilişkide, çeşitli basamaklarda rol oynamaktadır. Bu çalışmanın amacı, PK'li hastalarda siklooksijenaz-2 (COX), apopitozis ve anjiyogenezis arasında ilişki olup olmadığını belirlemektir.Gereç ve Yöntem: 2005-2010 yılları arasında, patolojik evresi pT2 olup radikal prostetektomi uygulanan 49 olgu, Çukurova Üniversitesi Tıp Fakültesi Patoloji arşivinden retrospektif olarak seçilmiştir. Histolojik slaytlar tanısal açıdan tekrar gözden geçirilmiş ve Gleason skorlama sistemine göre derecelendirilmiştir. Olgulara immünohistokimyasal olarak COX-2, vasküler endotelyal büyüme faktörü (VEBF), monoklonal antikor (M30), bcl-2 uygulanarak değerlendirilmiştir. Bulgular: Hastaların ortalama yaşı 63,8 idi. Yirmi bir hasta Gleason skor <=6 ve 28 hasta Gleason skor >=7 olarak derecelendirildi. COX-2 ekspresyonu %81,6 hastada tespit edildi. COX-2 ekspresyonu bcl-2 ekspresyonu ile korele olarak bulunurken, VEBF ile COX-2 arasında korelasyon saptanmadı. Gleason skor ile M30 arasında negatif korelasyon saptandı. Ortalama yaşam ve COX-2 arasında negatif korelasyon saptandı. COX-2 ekspresyonu arttıkça sağkalım süresinin anlamlı olarak azaldığı saptandı.Sonuç: Çalışmamız PK karsinogenezisinde COX-2'nin anjiyogenezisi arttırmaktan çok apopitozisi inhibe ederek etki ettiğini düşündürmektedir. Bu sonuçların, tedavi stratejilerine yeni bakış açıları sunabileceği gibi, hastaların klinik takiplerinin sonuçlarını öngörmede faydalı olabileceğini düşünmekteyiz.

Anahtar Kelime:

Konular: Üroloji ve Nefroloji Onkoloji

İmmünohistokimyasal Çalışma ile Prostat Karsinomunda Siklooksijenaz-2 Ekspresyonunun: Apopitozis ve Anjiyogenezis ile İlişkisi

Öz:

Objective: Prostate carcinoma (PC) is one of the most commonly diagnosed cancer types with significant rates of mortality and morbidity. The etiology of PC is not clear. Cytokine and mediators at the inflammatory pathway plays role at the various steps of the relation between chronic inflammation and cancer. The objective of this study is to determine if there is relationship between cyclooxygenase-2 (COX) apoptosis and angiogenesis in patients with PC.Materials and Methods: Sample of 49 cases who were at pathologic stage pT2 and underwent radical prostatectomy, were selected retrospectively between 2005-2010, from the archives of Pathology Department of Çukurova University Faculty of Medicine. Histologic slides of each case were reviewed for the diagnostic reassessment and graded by the Gleason scoring system. COX-2, vascular endothelial growth factor (VEGF), monoclonal antibody (M30) and bcl-2 were immunohistochemically applied to the cases and they were evaluated.Results: The mean age of the patients were 63.8. Twenty-one cases had their Gleason score <=6 and 28 had their Gleason score >=7. COX-2 expression was detected in 81.6% of cases. While COX-2 expression was significantly correlated with bcl-2 expression, there was no correlation between VEGF and COX-2 expression. Gleason score was negatively correlated with M30. It was detected that as COX-2 expression increased mean survival time significantly decreased.Conclusion: This study makes us think that in the PC carcinogenesis COX2 inhibits apoptosis rather than promoting angiogenesis. These results may offer new insights for the treatment strategies, also they may be useful for the prediction of clinical outcomes.

Anahtar Kelime:

Konular: Üroloji ve Nefroloji Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KILIÇ BAĞIR E, A�IKALIN A, Izol V, Seydaoglu G, ERDOĞAN Ş (2016). Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. , 144 - 147.
Chicago	KILIÇ BAĞIR EMİNE,A�IKALIN ARBIL,Izol Volkan,Seydaoglu Gulsah,ERDOĞAN Şeyda Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. (2016): 144 - 147.
MLA	KILIÇ BAĞIR EMİNE,A�IKALIN ARBIL,Izol Volkan,Seydaoglu Gulsah,ERDOĞAN Şeyda Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. , 2016, ss.144 - 147.
AMA	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. . 2016; 144 - 147.
Vancouver	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. . 2016; 144 - 147.
IEEE	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş "Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis." , ss.144 - 147, 2016.
ISNAD	KILIÇ BAĞIR, EMİNE vd. "Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis". (2016), 144-147.

APA	KILIÇ BAĞIR E, A�IKALIN A, Izol V, Seydaoglu G, ERDOĞAN Ş (2016). Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. Üroonkoloji Bülteni, 15(4), 144 - 147.
Chicago	KILIÇ BAĞIR EMİNE,A�IKALIN ARBIL,Izol Volkan,Seydaoglu Gulsah,ERDOĞAN Şeyda Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. Üroonkoloji Bülteni 15, no.4 (2016): 144 - 147.
MLA	KILIÇ BAĞIR EMİNE,A�IKALIN ARBIL,Izol Volkan,Seydaoglu Gulsah,ERDOĞAN Şeyda Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. Üroonkoloji Bülteni, vol.15, no.4, 2016, ss.144 - 147.
AMA	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. Üroonkoloji Bülteni. 2016; 15(4): 144 - 147.
Vancouver	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis. Üroonkoloji Bülteni. 2016; 15(4): 144 - 147.
IEEE	KILIÇ BAĞIR E,A�IKALIN A,Izol V,Seydaoglu G,ERDOĞAN Ş "Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis." Üroonkoloji Bülteni, 15, ss.144 - 147, 2016.
ISNAD	KILIÇ BAĞIR, EMİNE vd. "Immunohistochemical Study of Cyclooxygenase-2 Expression in Prostate Carcinoma: It's Relation with Apoptosis and Angiogenesis". Üroonkoloji Bülteni 15/4 (2016), 144-147.