Yıl: 2014 Cilt: 5 Sayı: 4 Sayfa Aralığı: 567 - 571 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi

Öz:
Amaç: Bu çalışmanın amacı fazla kilolu ve obez polikistik over sendromu (PKOS)'lu hastalar ile normal kilolu PKOS'lu kadınları klinik, hormonal ve metabolik özellikler açısından karşılaştırmaktı. Yöntemler: Çalışmaya yaşları 15-39 arasında değişen 119 PKOS'lu hasta dahil edildi. Tüm hastalarda antropometrik, metabolik ve hormonal ölçümler yapıldı. Bulgular: Fazla kilolu ve obez PKOS'lu hastalarla (n=78) normal kilolu hastalar (n=41) arasında Ferriman- Gallwey hirsutizm skoru açısından bir fark saptanmadı (p=0,373). Obez grubun %71,8'inde menstruel düzensizlik görülürken, normal kilolu grupta bu oran %60,9 idi (p=0,160). HOMA-IR değerleri obez grupta anlamlı derecede daha yüksekti (1,7±0,7'ye karşın 3,3±1,7, p<0,001). Serum trigliserid düzeyleri (87,2±49,8'e karşın 123,4±65,3 mg/dl) ve LDL-kolesterol düzeyleri (104,5±29,4'e karşın 121,7±32,9 mg/dl) obez grupta normal kilolu gruba göre anlamlı derecede yüksekti (p=0,002, p=0,006). HDL-kolesterol düzeyleri ise obez grupta anlamlı derecede daha düşüktü (46,5±11'e karşın 56,7±11,7 mg/dl, p<0,001). Serbest testosteron düzeyleri ise fazla kilolu ve obez PKOS'lularda 3,54±2,5 pg/ml iken, normal kilolu grupta 2,36±1,2 pg/ml olarak saptandı (p=0,016). VKİ yaş (r=0,210), bel çevresi (r=0,916), sistolik (r=0,238) ve diyastolik kan basıncı (r=0,181), insülin (r=0,635), HOMA-IR (r=0,650), total-K (r=0,242), LDL-K (r=0,295), trigliserid (r=0,424) ve total testosteron (r=0,230) ile pozitif korele iken, HDL-K (r=0,476) ile aralarında negatif bir ilişki saptandıSonuç: Bu çalışmada obezitenin PKOS'lu hastalarda hirsutizm ve menstruel düzen üzerine etkisi görülmedi, ancak insülin sensitivitesi ve lipid profilini kötüleştirdiği gözlendi.
Anahtar Kelime:

Konular: Kadın Hastalıkları ve Doğum Endokrinoloji ve Metabolizma

The impact of obesity on clinical, metabolic and hormonal features in patients with polycystic ovary syndrome

Öz:
Objectives: Our aim was to compare the clinical, hormonal and metabolic features between overweight and obese patients with PCOS and normal weight women with polycystic ovary syndrome (PCOS). Methods: 119 patients with PCOS (15-39 years) were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all patients.Results: Ferriman- Gallwey hirsutism score was similar in overweight or obese patients with PCOS (n=78) and normal weight patients with PCOS (n=41) (p=0.373). While 71.8% of the obese group had irregular menses, this ratio was 60.9% in normal weight group (p=0.160). HOMA-IR values were higher in the obese group (1.7±0.7 vs 3.3±1.7, p<0.001). Serum triglyceride (87.2±49.8 vs. 123.4±65.3 mg/dl) and LDL-cholesterol levels (104.5±29.4 vs 121.7±32.9 mg/dl) were higher in obese group than the normal weight group (p=0.002, p=0.006). HDL-cholesterol levels were lower in obese group (46.5±11 vs 56.7±11.7 mg/dl, p<0.001). Free testosterone levels were 3.54±2.5 pg/ml in overweight and obese group and 2.36 ± 1.2 pg/ml in normal weight group (p = 0.016). While BMI was positively correlated with age (r=0.210), waist circumference (r=0.916), systolic (r=0.238) and diastolic blood pressure (r=0.181), insulin (r=0.635), HOMA-IR (r=0.650), total-C ( r=0.242), LDL-C (r=0.295), triglyceride (r=0.424) and total testosterone (r=0.230), it was negatively correlated with HDL-C (r=-0.476).Conclusion: Obesity did not influence hirsutism and menstruel regularity in patients with PCOS in this study, however obesity deteriorated insulin sensitivity and lipid profile.
Anahtar Kelime:

Konular: Kadın Hastalıkları ve Doğum Endokrinoloji ve Metabolizma
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ŞAHİN S, sumer f, SEZGİN H, AYAZ T, ŞAHİN O, ilkkilic k, GÜR USLU E, ALGÜN E (2014). Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. , 567 - 571.
Chicago ŞAHİN Serap Baydur,sumer fatih,SEZGİN Hacer,AYAZ Teslime,ŞAHİN Osman Zikrullah,ilkkilic kadir,GÜR USLU Emine,ALGÜN Ekrem Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. (2014): 567 - 571.
MLA ŞAHİN Serap Baydur,sumer fatih,SEZGİN Hacer,AYAZ Teslime,ŞAHİN Osman Zikrullah,ilkkilic kadir,GÜR USLU Emine,ALGÜN Ekrem Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. , 2014, ss.567 - 571.
AMA ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. . 2014; 567 - 571.
Vancouver ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. . 2014; 567 - 571.
IEEE ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E "Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi." , ss.567 - 571, 2014.
ISNAD ŞAHİN, Serap Baydur vd. "Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi". (2014), 567-571.
APA ŞAHİN S, sumer f, SEZGİN H, AYAZ T, ŞAHİN O, ilkkilic k, GÜR USLU E, ALGÜN E (2014). Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. Journal of Clinical and Experimental Investigations, 5(4), 567 - 571.
Chicago ŞAHİN Serap Baydur,sumer fatih,SEZGİN Hacer,AYAZ Teslime,ŞAHİN Osman Zikrullah,ilkkilic kadir,GÜR USLU Emine,ALGÜN Ekrem Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. Journal of Clinical and Experimental Investigations 5, no.4 (2014): 567 - 571.
MLA ŞAHİN Serap Baydur,sumer fatih,SEZGİN Hacer,AYAZ Teslime,ŞAHİN Osman Zikrullah,ilkkilic kadir,GÜR USLU Emine,ALGÜN Ekrem Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. Journal of Clinical and Experimental Investigations, vol.5, no.4, 2014, ss.567 - 571.
AMA ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. Journal of Clinical and Experimental Investigations. 2014; 5(4): 567 - 571.
Vancouver ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi. Journal of Clinical and Experimental Investigations. 2014; 5(4): 567 - 571.
IEEE ŞAHİN S,sumer f,SEZGİN H,AYAZ T,ŞAHİN O,ilkkilic k,GÜR USLU E,ALGÜN E "Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi." Journal of Clinical and Experimental Investigations, 5, ss.567 - 571, 2014.
ISNAD ŞAHİN, Serap Baydur vd. "Polikistik over sendromlu hastalarda obezitenin klinik, metabolik ve hormonal özellikler üzerine etkisi". Journal of Clinical and Experimental Investigations 5/4 (2014), 567-571.