The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury

SUBASI, Cansu; DURUKSU, Gökhan; ERGUVAN, Mine; Sabancı, Pulat Akın; KARAGÖZ, Erdal; aras, yavuz; Kabatas, Serdar

The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury

Yavuz ARAS, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Pulat Akın SABANCI, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Serdar KABATAŞ, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye)

GÖKHAN DURUKSU, (Boş)

Cansu SUBASI, (Boş)

Mine ERGUVAN, (Boş)

Erdal KARAGÖZ (Boş)

Turkish Neurosurgery

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Yıl: 2016 Cilt: 26 Sayı: 1 Sayfa Aralığı: 127 - 139 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury

Öz:

AIM: To investigate the effectiveness of rat adipose tissue-derived (rAT) mesenchymal stem cell (MSC) transplantation on the functional restoration and regeneration of spinal cord injury (SCI).MATERIAl and METhODS: Six of 48 Wistar albino rats were sacrificed to obtain MSCs, and the remaining rats were divided randomly into six groups. SCI was performed using the clip compression method. The control and transplantation groups were injected with physiological saline and a rAT-MSC suspension at the injury sites, respectively. Each animal was evaluated using the Basso, Beattie and Bresnahan (BBB) rating system and sacrificed at 28 days post-injury period (p.i.). The regeneration process was evaluated based on immunostaining against ?3-tubulin, BDNF, CNTF, and CNPase. RESulTS: rAT-MSC transplantation into the SCI site substantially improved the tissue regeneration and functional recovery (p < 0.05). However, the rAT-MSC transplantation at 9 days p.i. was not more efficient on functional recovery than the transplantation immediately after injury. The expression of ?3-tubulin, BDNF and CNTF at the injury site indicated the potential for functional regeneration. COnCluSIOn: The adaptive nature of rat-MSCs enabled the remodulation and regeneration of the lesion site, decreasing the importance of transplantation time in the treatment of SCI

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	aras y, Sabancı P, Kabatas S, DURUKSU G, SUBASI C, ERGUVAN M, KARAGÖZ E (2016). The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. , 127 - 139.
Chicago	aras yavuz,Sabancı Pulat Akın,Kabatas Serdar,DURUKSU Gökhan,SUBASI Cansu,ERGUVAN Mine,KARAGÖZ Erdal The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. (2016): 127 - 139.
MLA	aras yavuz,Sabancı Pulat Akın,Kabatas Serdar,DURUKSU Gökhan,SUBASI Cansu,ERGUVAN Mine,KARAGÖZ Erdal The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. , 2016, ss.127 - 139.
AMA	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. . 2016; 127 - 139.
Vancouver	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. . 2016; 127 - 139.
IEEE	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E "The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury." , ss.127 - 139, 2016.
ISNAD	aras, yavuz vd. "The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury". (2016), 127-139.

APA	aras y, Sabancı P, Kabatas S, DURUKSU G, SUBASI C, ERGUVAN M, KARAGÖZ E (2016). The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. Turkish Neurosurgery, 26(1), 127 - 139.
Chicago	aras yavuz,Sabancı Pulat Akın,Kabatas Serdar,DURUKSU Gökhan,SUBASI Cansu,ERGUVAN Mine,KARAGÖZ Erdal The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. Turkish Neurosurgery 26, no.1 (2016): 127 - 139.
MLA	aras yavuz,Sabancı Pulat Akın,Kabatas Serdar,DURUKSU Gökhan,SUBASI Cansu,ERGUVAN Mine,KARAGÖZ Erdal The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. Turkish Neurosurgery, vol.26, no.1, 2016, ss.127 - 139.
AMA	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. Turkish Neurosurgery. 2016; 26(1): 127 - 139.
Vancouver	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury. Turkish Neurosurgery. 2016; 26(1): 127 - 139.
IEEE	aras y,Sabancı P,Kabatas S,DURUKSU G,SUBASI C,ERGUVAN M,KARAGÖZ E "The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury." Turkish Neurosurgery, 26, ss.127 - 139, 2016.
ISNAD	aras, yavuz vd. "The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury". Turkish Neurosurgery 26/1 (2016), 127-139.