Nowadays, as a result of the aging society and the increase in chronic diseases, expensive drugs and treatment methods have been started to be used. The best approach to use resources appropriately and to offer quality care service is defined as the evidence-based practice (EBP). There are many reasons why the importance of EBP has increased which include increase in medical errors, patients'demand for information, and decrease in the confidence in health professionals. Besides, evidence-based medicine strengthens the connection between getting information, and decision-making process, and confers scientific principles, and professionalism to diagnosis, treatment, and care process. Evidence-based health care is defined as to combine appropriate resources, patient preferences, expert opinion and the evidence obtained from scientific research in order to offer optimal care to patients. In order to develop EBP in nursing, it is necessary to do researches that can be carried into practice in clinics and to create a mechanism which will make the results accessible for the nurses. Also, it is necessary to enhance knowledge and skills in this field and to reduce the obstacles in the application of health care service based on scientific data. There are several individual and organizational barriers for nurses in terms of EBP. Individually, deficient skills of investigation of the nurses, their isoaltion from academic media which will analyze the investigations, and lack of self-confidence of the nurses in acceptance of this changing condition are important barriers of the nurses confronting evidence-based medical practices. From an organizational perspective, lack of sufficient time reserved for implementation of research findings, and nurses 'disbelief in their authority, and autonomy in application of these changes, during critical conditions, and inadequate organizational support have been emphasized.The main prerequisite of being a professional nurse is surely to understand the science and scientific method properly and to reflect these to the job. In the future, due to the researches which are done by using scientific methods, nurses will be more aware to make evidence-based decisions rather than experience-based ones. Also, this will cause an increase in the number of nurses who can produce their own knowledge and who can take more responsibility for the scientific value and the use of knowledge. However, in order to achieve this aim; it is necessary for nurses to work by building team spirit which will produce researches and use the evidence of these researches.