Analysis of 161 adult patients with brucellosis
Yıl: 2013 Cilt: 43 Sayı: 2 Sayfa Aralığı: 187 - 193 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Analysis of 161 adult patients with brucellosis
Öz: Aim: To evaluate the epidemiology, clinical features, and complications of brucellosis. Materials and methods: Between January 2005 and December 2008, 161 patients with brucellosis who were admitted to our clinic were evaluated prospectively. Results: Of the patients, 97 (60.2%) were male, and the mean age was 47 ± 17 years (range: 16 79). There were 99 patients (61.5%) classified as acute, 36 (22.4%) classified as subacute, and 6 (3.7%) classified as having a chronic infection. Relapse or reinfection was observed in 20 (12.4%) patients. Blood culture positivity rates were 60.7% and 44.8% among acute and subacute cases, respectively (P = 0.008). In 40 of 70 culture positive patients, standard Brucella tube agglutination titers were found above 1/1280 (P = 0.03). Blood culture positivity was also higher in febrile patients (P = 0.001). Complications were detected in 66 of 161 patients (41.0%). Osteoarticular system involvement was the most common complication (50 patients, 31.1%). Fever, positive blood cultures, and hepatosplenomegaly were significantly higher in the group without complications (P < 0.05). Complications were significantly lower in acute infections than in subacute infections (P < 0.05). There were also higher complication rates detected in the patients with reinfection and relapse (P < 0.05). Conclusion: In endemic regions, brucellosis is an important infectious disease causing chronic infections and complications.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Koneman EW. Brucella species. In: Koneman EW, Allen DS, Janda WM, Shreckenberger PC, Winn WC, editors. Color atlas and textbook of diagnostic microbiology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 1997. p.4316.
- 2. Young EJ. Brucella species. In: Mandell GL, Bennet JE, Dolin R, editors. Principles and practice of infectious diseases. Philadelphia: Churchill Livingstone; 2005. p.266974.
- 3. Atmaca S, Özekinci T, Akpolat N, Elçi S, Suay A, Arıkan E. Brucellosis seroprevalence in Southeast Turkey (Diyarbakır). Turk J Med Sci 2004; 34: 2515.
- 4. Gwida M, Al Dahouk S, Melzer F, Rösler U, Neubauer H, Tomaso H. Brucellosis- regionally emerging zoonotic disease? Croat Med J 2010; 51: 28995.
- 5. Yumuk Z, OCallaghan D. Brucellosis in Turkey - an overview. Int J Infect Dis 2012; 16: 22835.
- 6. Solera J, Martinez-Alfaro E, Espinosa A. Recognition and optimum treatment of brucellosis. Drugs 1997; 53: 24556.
- 7. Doğanay M, Meşe EA. Topçu AW, Söyletir G, Doğanay M, eds. İnfeksiyon hastalıkları ve mikrobiyolojisi. Ankara: Nobel Tıp Kitapevleri; 2008. p.897909 (in Turkish).
- 8. Akdeniz H, Irmak H, Demiröz AP. Evaluation of brucellosis cases in Van region of Eastern Anatolia: a 3 year experience. Nogoya Med J 1998; 42: 10110.
- 9. Taşova Y, Saltoğlu N, Yılmaz G, İnal S, Aksu HSZ. Bruselloz: 238 erişkin olgunun klinik, laboratuvar ve tedavi özelliklerinin değerlendirilmesi. Turkish J Infect 1998; 12: 30712 (in Turkish).
- 10. Kadanali A, Ozden K, Altoparlak U, Erturk A, Parlak M. Bacteremic and nonbacteremic brucellosis: clinical and laboratory observations. Infection 2009; 37: 679.
- 11. Colmenero JD, Reguera JM, Mortos F, Sanchez-De-Mora D, Delgado M, Causse M et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75: 195211.
- 12. Aygen B, Sümerken B, Kardaş Y, Doğanay M, İnan M. Bruselloz: 183 olgunun değerlendirilmesi. KLİMİK Derg 1995; 8: 136 (in Turkish).
- 13. Solera J, Lozano E, Martinez, Alfaro E, Espinosa A, Castillejos ML et al. Brucellar spondylitis: review of 35 cases and literature survey. Clin Infect Dis 1999; 29: 14409.
- 14. Çalık Ş, Gökengin AD. Human brucellosis in Turkey: a review of the literature between 1990 and 2009. Turk J Med Sci 2011; 41: 54955.
- 15. Bulut C, Yetkin MA, Yılmaz G, Erdinç FŞ, Hatipoğlu ÇA, Kınıklı S et al. Assessment of the findings on the existence of complications in brucellosis. Turk J Med Sci 2011; 41: 27582.
- 16. Bodur H, Erbay A, Colpan A, Akinci E. Brucellar spondylitis. Rheumatol Int 2004; 24: 2216.
- 17. Kadanali A, Varoglu E, Kerek M, Tasyaran MA. Tc-99m polyclonal human immunoglobulin scintigraphy in brucellosis. Clin Microbiol Infect 2005; 11: 4805.
- 18. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 2010; 14: e46978.
- 19. Aygen B, Eşel D, Erdoğan N, Sümerkan B, Doğanay M. Psoas abscess secondary to brucellar spondylitis. Turk J Med Sci 2002; 32: 813.
- 20. Kurtaran B, Candevir A, İnal AS, Kömür S, Akyıldız Ö, Saltoğlu N et al. Clinical appearance of brucellosis in adults: fourteen years of experience. Turk J Med Sci 2012; 42: 497505.
- 21. Taşova Y, Saltoğlu N, Şahin G, Aksu HSZ. Osteoarticular involvement of brucellosis in Turkey. Clin Rheumatol 1999; 18: 2149.
- 22. Gotuzzo E, Carillo C. Brucella. In: Gorbach SL, Barlett JG, Blacklow NR, editors. Infectious diseases. 3rded. Philadelphia: Lippincott Williams & Wilkins; 2004. p.171724.
- 23. Ariza J, Pujol M, Valverde J, Nolla JM, Rufí G, Viladrich PF et al. Brucellar sacroiliitis: findings in 63 episodes and current relevance. Clin Infect Dis 1993; 16: 7615.
- 24. Hashemi SH, Keramat F, Ranjbar M, Mamani M, Farzam A, Jamal-Omidi S. Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran. Int J Infect Dis 2007; 11: 496500.
- 25. Khateeb MI, Araj GF, Majeed SA, Lulu AR. Brucella arthritis: a study of 96 cases in Kuwait. Ann Rheum Dis 1990; 49: 9948.
- 26. Resnick D, Niwayama G. Osteomyelitis, septic arthritis, and soft tissue infection: organisms. In: Resnick D, editor. Diagnosis of bone and joint disorders. Philadelphia: WB Saunders Company; 1995. p.2448558.
- 27. Montejo JM, Alberolo I, Glez-Zarete P, Alvarez A, Alonso J, Canovas A et al. Open randomized therapeutic trial of six antimicrobial regimens in the treatment of human brucellosis. Clin Infect Dis 1993; 16: 6716.
- 28. Cisneros JM, Viciana P, Colmenero J, Pachon J, Martinez C, Alarcon A. Multicenter prospective study of treatment of Brucella melitensis brucellosis with doxycycline for 6 weeks plus streptomycin for 2 weeks. Antimicrob Agent Chemother 1990; 34: 8813.
- 29. Akinci E, Bodur H, Cevik MA, Erbay A, Eren SS, Ziraman I et al. A complication of brucellosis: epididymoorchitis. Int J InfectDis 2006; 10: 1717.
- 30. Bodur H, Erbay A, Akinci E, Çolpan A, Çevik MA, Balaban N. Neurobrucellosis in an endemic area of brucellosis. Scand J Infect Dis 2003; 35: 947.
- 31. Yetkin MA, Bulut C, Erdinc FS, Oral B, Tulek N. Evaluation of the clinical presentations in neurobrucellosis. Int J Infect Dis 2006; 10: 44652.
- 32. Kizilkilic O, Calli C. Neurobrucellosis. Neuroimaging Clin N Am 2011; 21: 92737.
- 33. Bouza E, García de la Torre M, Parras F, Guerrero A, RodríguezCréixems M, Gobernado J et al. Brucellar meningitis. Rev Infect Dis 1987; 9: 81022.
- 34. Bodur H, Balaban N, Aksaray S, Yetener V, Akinci E, Colpan A et al. Biotypes and antimicrobial susceptibilities of Brucella isolates. Scand J Infect Dis 2003; 35: 3378.
- 35. Ayaşlıoğlu E, Kılıç S, Aydın K, Kılıç D, Kaygusuz S, Ağalar C. Antimicrobial susceptibility of Brucella melitensis isolates from blood samples. Turk J Med Sci 2008; 38: 25762.
- 36. Kaya O, Akçam FZ, Yaylı G. Investigation of the in vitro activities of various antibiotics against Brucella melitensis strains. Turk J Med Sci 2012; 42: 1458.
- 37. Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents 2010; 36: S1820.
- 38. del Pozo JSG, Solera J. Systematic review and meta-analysis of randomized clinical trials in the treatment of human brucellosis. PLoSOne 2012; 7: e32090.
- 39. Al Dahouk S, Nöckler K. Implications of laboratory diagnosis on brucellosis therapy. Expert Rev Anti Infect Ther 2011; 9: 83345.
- 40. Gotuzzo E, Carrillo C, Guerra J, Llosa L. An evaluation of diagnostic methods for brucellosis-the value of bone marrow culture. J Infect Dis 1986; 153: 1225.
- 41. Özkurt Z, Kaya A, Taşyaran MA, Yılmaz Ş. Bruselloz tanısında standart tüp aglütinasyon testi, kan ve kemik iliği kültürlerinin tanı değerlerinin karşılaştırılması. İnfeksiyon Dergisi 2000; 14: 4638 (in Turkish).
- 42. Eales KM, Norton RE, Ketheesan N. Brucellosis in Northern Australia. Am J Trop Med Hyg 2010; 83: 8768.
APA | Kayaaslan B, AKINCI E, BAŞTUĞ A, EREN S, onguru p, BUT A, YETKİN M, BODUR H (2013). Analysis of 161 adult patients with brucellosis. , 187 - 193. |
Chicago | Kayaaslan Bircan,AKINCI Esragül,BAŞTUĞ Aliye,EREN Selim Sırrı,onguru pinar,BUT Ayşe,YETKİN Meltem Arzu,BODUR HURREM Analysis of 161 adult patients with brucellosis. (2013): 187 - 193. |
MLA | Kayaaslan Bircan,AKINCI Esragül,BAŞTUĞ Aliye,EREN Selim Sırrı,onguru pinar,BUT Ayşe,YETKİN Meltem Arzu,BODUR HURREM Analysis of 161 adult patients with brucellosis. , 2013, ss.187 - 193. |
AMA | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H Analysis of 161 adult patients with brucellosis. . 2013; 187 - 193. |
Vancouver | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H Analysis of 161 adult patients with brucellosis. . 2013; 187 - 193. |
IEEE | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H "Analysis of 161 adult patients with brucellosis." , ss.187 - 193, 2013. |
ISNAD | Kayaaslan, Bircan vd. "Analysis of 161 adult patients with brucellosis". (2013), 187-193. |
APA | Kayaaslan B, AKINCI E, BAŞTUĞ A, EREN S, onguru p, BUT A, YETKİN M, BODUR H (2013). Analysis of 161 adult patients with brucellosis. Turkish Journal of Medical Sciences, 43(2), 187 - 193. |
Chicago | Kayaaslan Bircan,AKINCI Esragül,BAŞTUĞ Aliye,EREN Selim Sırrı,onguru pinar,BUT Ayşe,YETKİN Meltem Arzu,BODUR HURREM Analysis of 161 adult patients with brucellosis. Turkish Journal of Medical Sciences 43, no.2 (2013): 187 - 193. |
MLA | Kayaaslan Bircan,AKINCI Esragül,BAŞTUĞ Aliye,EREN Selim Sırrı,onguru pinar,BUT Ayşe,YETKİN Meltem Arzu,BODUR HURREM Analysis of 161 adult patients with brucellosis. Turkish Journal of Medical Sciences, vol.43, no.2, 2013, ss.187 - 193. |
AMA | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H Analysis of 161 adult patients with brucellosis. Turkish Journal of Medical Sciences. 2013; 43(2): 187 - 193. |
Vancouver | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H Analysis of 161 adult patients with brucellosis. Turkish Journal of Medical Sciences. 2013; 43(2): 187 - 193. |
IEEE | Kayaaslan B,AKINCI E,BAŞTUĞ A,EREN S,onguru p,BUT A,YETKİN M,BODUR H "Analysis of 161 adult patients with brucellosis." Turkish Journal of Medical Sciences, 43, ss.187 - 193, 2013. |
ISNAD | Kayaaslan, Bircan vd. "Analysis of 161 adult patients with brucellosis". Turkish Journal of Medical Sciences 43/2 (2013), 187-193. |