Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Rana SIRMALI, (Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Biyokimya Bölümü, İstanbul, Türkiye)
Abdullah ARMAĞAN, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)
Faruk ÖKTEM, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Çocuk Nefroloji Bilim Dalı, İstanbul, Türkiye)
Efkan UZ, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Isparta, Türkiye)
Aynur KIRBAŞ, (Süleyman Demirel Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Isparta, Türkiye)
Soner DÖNMEZ, (Nevşehir Üniversitesi, Kimya Bölümü, Biyokimya Anabilim Dalı, Nevşehir, Türkiye)
Hacı Ramazan YILMAZ, (Mevlana Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Bölümü, Konya, Türkiye)
Mesrur Selçuk SILAY, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)
Mehmet SIRMALI (Department of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.)
Turkish Journal of Medical Sciences
6 0
Yıl: 2015 Cilt: 45 Sayı: 1 Sayfa Aralığı: 33 - 37 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Öz:
Background/aim: To compare the protective efficacy of erdosteine and vitamins C and E against renal injury caused by hind limb ischemia-reperfusion (I/R). Materials and methods: Rats were split into 4 groups: group I as the control, group II as I/R, group III as I/R + erdosteine, and group IV as I/R + vitamins C and E. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) tissue levels were determined. Results: MDA levels were found comparable with the control group in groups II and III. However, they were considerably decreased in group IV when compared to group II (P < 0.01). Additionally, SOD, CAT, and GSH-Px activities were considerably (P < 0.05) decreased in group II. While CAT and GSH-Px activities were restored (P < 0.01) by vitamin E and C treatment, SOD activity was not significantly affected. While GSH-Px activities were higher (P < 0.05) with erdosteine administration, SOD and CAT activities were unchanged. Conclusion: The protective effect of vitamins C and E is higher than that of erdosteine treatment in reducing the oxidative stress after renal ischemia in this animal model.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SIRMALI R, ARMAĞAN a, ÖKTEM F, UZ E, Kırbaş A, Donmez S, YILMAZ H, SILAY M, SIRMALI M (2015). Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. , 33 - 37.
Chicago SIRMALI Rana,ARMAĞAN abdullah,ÖKTEM Faruk,UZ Efkan,Kırbaş Aynur,Donmez Soner,YILMAZ Hacı Ramazan,SILAY MESRUR SELCUK,SIRMALI Mehmet Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. (2015): 33 - 37.
MLA SIRMALI Rana,ARMAĞAN abdullah,ÖKTEM Faruk,UZ Efkan,Kırbaş Aynur,Donmez Soner,YILMAZ Hacı Ramazan,SILAY MESRUR SELCUK,SIRMALI Mehmet Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. , 2015, ss.33 - 37.
AMA SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. . 2015; 33 - 37.
Vancouver SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. . 2015; 33 - 37.
IEEE SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M "Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats." , ss.33 - 37, 2015.
ISNAD SIRMALI, Rana vd. "Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats". (2015), 33-37.
APA SIRMALI R, ARMAĞAN a, ÖKTEM F, UZ E, Kırbaş A, Donmez S, YILMAZ H, SILAY M, SIRMALI M (2015). Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. Turkish Journal of Medical Sciences, 45(1), 33 - 37.
Chicago SIRMALI Rana,ARMAĞAN abdullah,ÖKTEM Faruk,UZ Efkan,Kırbaş Aynur,Donmez Soner,YILMAZ Hacı Ramazan,SILAY MESRUR SELCUK,SIRMALI Mehmet Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. Turkish Journal of Medical Sciences 45, no.1 (2015): 33 - 37.
MLA SIRMALI Rana,ARMAĞAN abdullah,ÖKTEM Faruk,UZ Efkan,Kırbaş Aynur,Donmez Soner,YILMAZ Hacı Ramazan,SILAY MESRUR SELCUK,SIRMALI Mehmet Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. Turkish Journal of Medical Sciences, vol.45, no.1, 2015, ss.33 - 37.
AMA SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. Turkish Journal of Medical Sciences. 2015; 45(1): 33 - 37.
Vancouver SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats. Turkish Journal of Medical Sciences. 2015; 45(1): 33 - 37.
IEEE SIRMALI R,ARMAĞAN a,ÖKTEM F,UZ E,Kırbaş A,Donmez S,YILMAZ H,SILAY M,SIRMALI M "Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats." Turkish Journal of Medical Sciences, 45, ss.33 - 37, 2015.
ISNAD SIRMALI, Rana vd. "Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats". Turkish Journal of Medical Sciences 45/1 (2015), 33-37.
Sayfa Oluşturulma Tarihi
23-04-2024 0:27

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