Investigation of West Nile virus among healthy blood donors in the western part of Turkey

KARATAYLI, Ersin; SERTÖZ, ŞAZİYE RÜÇHAN; BAYRAM, ARZU; TURHAN, Ajda; DEĞİRMENCİ, Aysu; AYDINOK, Yeşim; BOZDAYI, ABDURRAHMAN MITHAT; BİÇEROĞLU ULUER, Servet

Investigation of West Nile virus among healthy blood donors in the western part of Turkey

Servet BİÇEROĞLU ULUER, (Ege Üniversitesi Tıp Fakültesi, Kan Bankası, İzmir, Türkiye)

Ersin KARATAYLI, (Ankara Üniversitesi, Tıp Fakültesi, Hepatoloji Enstitüsü, Ankara, Türkiye)

Arzu BAYRAM, (Ege Üniversitesi, Tıp Fakültesi, Klinik Mikrobiyoloji Anabilim Dalı, İzmir, Türkiye)

Ajda TURHAN, (Ege Üniversitesi Tıp Fakültesi, Kan Bankası, İzmir, Türkiye)

Aysu DEĞİRMENCİ, (Ege Üniversitesi Tıp Fakültesi, Kan Bankası, İzmir, Türkiye)

Yeşim AYDINOK, (Ege Üniversitesi, Tıp Fakültesi, Çocuk Hematolojisi Anabilim Dalı, İzmir, Türkiye)

Abdurrahman Mithat BOZDAYI, (Ankara Üniversitesi, Tıp Fakültesi, Hepatoloji Enstitüsü, Ankara, Türkiye)

Şaziye Rüçhan SERTÖZ (Ege Üniversitesi, Tıp Fakültesi, Klinik Mikrobiyoloji Anabilim Dalı, İzmir, Türkiye)

Turkish Journal of Medical Sciences

8 1

Yıl: 2015 Cilt: 45 Sayı: 1 Sayfa Aralığı: 84 - 88 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Investigation of West Nile virus among healthy blood donors in the western part of Turkey

Öz:

Background/aim: The West Nile virus (WNV) is a mosquito-borne flavivirus causing different forms of infection among humans, varying from asymptomatic illness to fetal central nervous system infection. Turkey lies within an endemic region for WNV. Transfusion of infected blood products is another well-documented major route of transmission. The aim of our study was to investigate the presence of WNV viremia among a healthy donor population from the western part of the country. Materials and methods: A total of 438 healthy volunteer blood donors were included in the study. The presence of WNV RNA was investigated by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) and anti-WNV IgG was detected by a commercial ELISA test. Results: Ages of volunteer donors were 18 62 years (mean: 34.7) and 34 (7.76%) were women. All samples were negative for WNV RNA by qRT-PCR. Eleven (2.51%) samples, 1 of which was borderline, were positive for anti-WNV IgG. All positive samples were from the western part of the country and 9 of them were from İzmir. Conclusion: Although all donor samples were negative for WNV RNA by qRT-PCR, the risk of WNV transmission via blood products should not be ignored in endemic regions.

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Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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1. Smithburn KC, Hughes TP, Burke AW, Paul JH. A neurotropic virus isolated from the blood of native of Uganda. Am J Trop Med 1940; 20: 471492.
2. Pealer LN, Marfin AA, Petersen LR, Lanciotti RS, Page PL, Stramer SL, Stobierski MG, Signs K, Newman B et al. Transmission of West Nile virus through blood transfusion in the United States in 2002. N Engl J Med 2003; 349: 12361245.
3. Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S, Lanciotti RS, Lance-Parker SE et al. Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med 2003; 348: 21962203.
4. CDC. Possible West Nile virus transmission to an infant through breast-feeding--Michigan, 2002. MMWR Morb Mortal Wkly Rep 2002; 51: 877878.
5. Hayes EB, Sejvar JJ, Zaki SR, Lanciotti RS, Bode AV, Campbell GL. Virology, pathology, and clinical manifestations of West Nile virus disease. Emerg Infect Dis 2005; 11: 11741179.
6. Maxmen A. The hidden threat of West Nile virus. Nature 2012; 489: 349350.
7. Nolan MS, Podoll AS, Hause AM, Finkel KW, Murray KO. Prevalence of chronic kidney disease and progression of disease over time among patients enrolled in Houston West Nile virus cohort. PLoS ONE 2012; 7: e40374.
8. Gibney KB, Lanciotti RS, Sejvar JJ, Nugent CT, Linnen JM, Delorey MJ, Lehman JA, Boswell EN, Staples JE, Fischer M. West Nile virus not detected in urine of 40 people tested 6 years after acute West Nile Virus disease. J Infect Dis 2011; 203: 344 347.
9. Nash D, Mostashari F, Fine A, Miller J, OLeary D, Murray K, Huang A, Rosenberg A, Greenberg A, Sherman M et al. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 2001; 344: 18071814.
10. Hubalek Z, Halouzka J. West Nile Fevera reemerging mosquito-borne viral disease in Europe. Emerg Infect Dis 1999; 5: 643650.
11. Tsai TF, Popovici F Cernesu C, Campbell GL, Nedelcu NI. West Nile encephalitis epidemic in southeastern Romania. Lancet 1998; 352: 767771.
12. Platonov AE, Shiupin GA, Shipulina OY, Tyutyunnik EN, Frolochkina TI, Lanciotti RS, Yazyshina S, Platonova OV, Obukhov IL, Zhukov AN et al. Outbreak of West Nile virus infection. Volgograd Region, Russia, 1999. Emerg Infect Dis 2001; 7: 128132.
13. Weinberg M, Pitlik SD, Gandacu D, Lang R, Nassar F, Ben David D, Rubinstein E, Izthaki A, Mishal J, Kitzes R et al. West Nile fever outbreak, Israel, 2000: epidemiologic aspects. Emerg Infect Dis 2001; 7: 686691.
14. Barzon L, Squarzon J, Cattai M, Franchin E, Pagni S, Cusinato R, Palu G. West Nile virus infection in Veneto region, Italy, 2008-2009. Euro Surveill 2009; 14: 19289.
15. Papa A, Dannis K, Baka A, Bakas A, Douglas G, Lytras T, Theocharapoulos G, Chrysagis D, Vassiliadou E, Kamaria F et al. Ongoing outbreak of West Nile virus infection in humans in Greece, July-August 2010. Euro Surveill 2010; 15: 19644.
16. Kalaycioglu H, Korukluoglu G, Ozkul A, Oncul O, Tosun S, Karabay O, Gozalan A, Uyar Y, Caglayık DY, Atasoylu G et al. Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. Euro Surveill 2012; 17: 20182.
17. Danis K, Papa A, Thecharopoulus G, Dougas G, Athanasiou M, Detsis M, Baka A, Lytras T, Mellou K, Bonovas S et al. Outbreak of West Nile virus infection in Greece, 2010. Emerg Infect Dis 2011; 17: 18621872.
18. EpiSouth. West Nile Virus Circulation in the EpiSouth Countries and Neighboring Areas. Seasons 2010 and 2011. Rome, Italy: EpiSouth; 2012.
19. Sirbu A, Ceianu CS, Panculescu-Gatej RI, Vázquez A, Tenorio A, Rebreanu R, Niedrig M, Nicolescu G, Pistol A. Outbreak of West Nile virus infection in humans, Romania, July to October 2010. Euro Surveill 2011; 16: 19762.
20. Barzon L, Pacenti M, Cusinato R, Cattai M, Franchin E, Pagni S, Martello T, Bressan S, Squarzon L, Cattelan A et al. Human cases of West Nile Virus Infection in north-eastern Italy, 15 June to 15 November 2010 Euro Surveill 2011; 16: 19949.
21. European Centre for Disease Prevention and Control (ECDC). Epidemiological Update: End of West Nile Virus Transmission Season in Europe. Stockholm, Sweden: ECDC; 2011.
22. Roehr B. Texas records worst outbreak of West Nile virus on record. BMJ 2012; 345: e6019.
23. European Centre for Disease Prevention and Control (ECDC). West Nile Fever Maps. Situation Update 30/11/2012. Stockholm, Sweden: ECDC; 2012.
24. Eiden M, Vina-Rodriguez A, Hoffmann B, Ziegler U, Groschup MH. Two new real-time quantitative reverse transcription polymerase chain reaction assays with unique target sites for the specific and sensitive detection of lineages 1 and 2 West Nile virus strains. J Vet Diagn Invest 2010; 22: 748753.
25. Biggerstaff BJ, Petersen LR. Estimated risk of West Nile virus transmission through blood transfusion during an epidemic in Queens, New York City. Transfusion 2002; 42: 10191026.
26. Harrington T, Kuehnert MJ, Kamel H, Lanciotti RS, Hand S, Currier M, Chamberland ME, Petersen LR, Marfin AA. West Nile virus infection transmitted by blood transfusion. Transfusion 2003; 43: 10181022.
27. Busch MP, Caglioti S, Robertson EF, McAuley JD, Tobler LH, Kamel H, Linnen JM, Shyamala V, Tomasulo P, Kleinman SH. Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing. N Engl J Med 2005; 353: 460467.
28. Stramer SL, Fang CT, Foster GA, Wagner AG, Brodsky JP, Dodd RY. West Nile virus among blood donors in the United States, 2003 and 2004. N Engl J Med 2005; 353: 451459.
29. Montgomery SP, Brown JA, Kuehnert M, Smith TL, Crall N, Lanciotti RS, Macedo de Oliveira A, Boo T, Marfin AA; 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team. Transfusion-associated transmission of West Nile virus, United States 2003 through 2005. Transfusion 2006; 46: 20382046.
30. Biggerstaff BJ, Petersen LR. A modeling framework for evaluation and comparison of trigger strategies for switching from minipool to individual-donation testing for West Nile virus. Transfusion 2009; 49: 11511159.
31. Serter D. Present status of arbovirus sero-epidemiology in the Aegean region of Turkey. In: Vesenjak-Hirjan J, Caliserh C, editors. Arboviruses in the Mediterranean Countries. Stuttgart, Germany: Gustav Fischer Verlag; 1980.
32. Ayturan Ş, Aydoğan S, Ergünay K, Özcebe Oİ, Us D. Investigation of West Nile virus seroprevalence in Hacettepe University Hospital blood donors and confirmation of the positive results by plaque reduction neutralization test. Mikrobiyol Bul 2011; 45: 113124 (in Turkish with an abstract in English).
33. Ergünay K, Saygan MB, Aydoğan S, Menemenlioğlu D, Turan HM, Özkul A, Us D. West Nile virus seroprevalence in blood donors from Central Anatolia, Turkey. Vector Borne Zoonotic Dis 2010; 10: 771775.
34. Hizel K, Yenicesu İ, Erdal B, Yeşilyurt E, Fidan I, Kalkancı A, Dilsiz G. Investigation of West Nile virus seroprevalence in healthy blood donors. Mikrobiyol Bul 2010; 44: 425430 (in Turkish with an abstract in English).
35. Şahiner F, Avcı İY, Bedir O, Koru Ö, Şener K, Yapar M, Kubar A. Investigation of West Nile virus RNA in blood donors by real-time RT-PCR. Mikrobiyol Bul 2012; 46: 464469 (in Turkish with an abstract in English).
36. Karabay O, Tuna N, Yahyaoğlu M, Öztürk G. High cerebrospinal fluid protein level in West Nile virus encephalitis: report of five cases. Turk J Med Sci 2012; 42: 11421146.
37. Yeşilkaya A, Kurt Azap Ö, Arslan H, Yağcı Çağlayık D, Uyar Y, Korukluoğlu G, Özkul A. A fatal case of West Nile virus encephalitis. Mikrobiyol Bul 2012; 46: 488492 (in Turkish with an abstract in English).
38. Öcal M, Önder H, Arsava EM, Alp Ş, Özkul A, Ergünay K. A case of central nervous system infection due to West Nile virus lineage-1 in Ankara province, Turkey. Mikrobiyol Bul 2013; 47: 164172 (in Turkish with an abstract in English).

APA	BİÇEROĞLU ULUER S, KARATAYLI E, BAYRAM A, TURHAN A, DEĞİRMENCİ A, AYDINOK Y, BOZDAYI A, SERTÖZ Ş (2015). Investigation of West Nile virus among healthy blood donors in the western part of Turkey. , 84 - 88.
Chicago	BİÇEROĞLU ULUER Servet,KARATAYLI Ersin,BAYRAM ARZU,TURHAN Ajda,DEĞİRMENCİ Aysu,AYDINOK Yeşim,BOZDAYI ABDURRAHMAN MITHAT,SERTÖZ ŞAZİYE RÜÇHAN Investigation of West Nile virus among healthy blood donors in the western part of Turkey. (2015): 84 - 88.
MLA	BİÇEROĞLU ULUER Servet,KARATAYLI Ersin,BAYRAM ARZU,TURHAN Ajda,DEĞİRMENCİ Aysu,AYDINOK Yeşim,BOZDAYI ABDURRAHMAN MITHAT,SERTÖZ ŞAZİYE RÜÇHAN Investigation of West Nile virus among healthy blood donors in the western part of Turkey. , 2015, ss.84 - 88.
AMA	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş Investigation of West Nile virus among healthy blood donors in the western part of Turkey. . 2015; 84 - 88.
Vancouver	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş Investigation of West Nile virus among healthy blood donors in the western part of Turkey. . 2015; 84 - 88.
IEEE	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş "Investigation of West Nile virus among healthy blood donors in the western part of Turkey." , ss.84 - 88, 2015.
ISNAD	BİÇEROĞLU ULUER, Servet vd. "Investigation of West Nile virus among healthy blood donors in the western part of Turkey". (2015), 84-88.

APA	BİÇEROĞLU ULUER S, KARATAYLI E, BAYRAM A, TURHAN A, DEĞİRMENCİ A, AYDINOK Y, BOZDAYI A, SERTÖZ Ş (2015). Investigation of West Nile virus among healthy blood donors in the western part of Turkey. Turkish Journal of Medical Sciences, 45(1), 84 - 88.
Chicago	BİÇEROĞLU ULUER Servet,KARATAYLI Ersin,BAYRAM ARZU,TURHAN Ajda,DEĞİRMENCİ Aysu,AYDINOK Yeşim,BOZDAYI ABDURRAHMAN MITHAT,SERTÖZ ŞAZİYE RÜÇHAN Investigation of West Nile virus among healthy blood donors in the western part of Turkey. Turkish Journal of Medical Sciences 45, no.1 (2015): 84 - 88.
MLA	BİÇEROĞLU ULUER Servet,KARATAYLI Ersin,BAYRAM ARZU,TURHAN Ajda,DEĞİRMENCİ Aysu,AYDINOK Yeşim,BOZDAYI ABDURRAHMAN MITHAT,SERTÖZ ŞAZİYE RÜÇHAN Investigation of West Nile virus among healthy blood donors in the western part of Turkey. Turkish Journal of Medical Sciences, vol.45, no.1, 2015, ss.84 - 88.
AMA	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş Investigation of West Nile virus among healthy blood donors in the western part of Turkey. Turkish Journal of Medical Sciences. 2015; 45(1): 84 - 88.
Vancouver	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş Investigation of West Nile virus among healthy blood donors in the western part of Turkey. Turkish Journal of Medical Sciences. 2015; 45(1): 84 - 88.
IEEE	BİÇEROĞLU ULUER S,KARATAYLI E,BAYRAM A,TURHAN A,DEĞİRMENCİ A,AYDINOK Y,BOZDAYI A,SERTÖZ Ş "Investigation of West Nile virus among healthy blood donors in the western part of Turkey." Turkish Journal of Medical Sciences, 45, ss.84 - 88, 2015.
ISNAD	BİÇEROĞLU ULUER, Servet vd. "Investigation of West Nile virus among healthy blood donors in the western part of Turkey". Turkish Journal of Medical Sciences 45/1 (2015), 84-88.