Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

XIANG, Mei; ZHAO, Denmei; OUYANG, Jun; Li, Yong; SUN, Lizhou

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

Yong LI, (Department of Gynecology, Changzhou Maternal and Child Health Hospital Affiliated to Nangjing Medical University, Changzhou, China)

Lizhou SUN, (Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China)

Denmei ZHAO, (Department of Gynecology, Changzhou Maternal and Child Health Hospital Affiliated to Nangjing Medical University, Changzhou, China)

Jun OUYANG, (Department of Pathology, Changzhou Maternal and Child Health Hospital Affiliated to Nangjing Medical University, Changzhou, China)

Mei XIANG (Department of Gynecology, Changzhou Maternal and Child Health Hospital Affiliated to Nangjing Medical University, Changzhou, China)

Turkish Journal of Medical Sciences

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Yıl: 2015 Cilt: 45 Sayı: 1 Sayfa Aralığı: 214 - 220 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence

Öz:

Background/aim: Tubal pregnancy is a major cause of maternal death in the first trimester and exploration of its underlying molecular mechanism is of great importance. This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues. Materials and methods: Immunohistochemistry was performed to probe the differential expression of LIF and LIFR in oviduct tissues among a control group (including NP group, n = 11; and IP group, n = 12), tubal pregnancy group (Ect-N group, n = 31; and Ect-A group, n = 40), and chronically inflamed group (including Inf-S group, n = 11; and Inf-P group, n = 9), followed by semiquantitative analysis. Results: Semiquantitative immunohistochemical analysis demonstrated that there was no significant difference in LIF expression in either the epithelial or stromal cells of oviduct tissues between the tubal pregnancy group and the control group (P < 0.05). However, LIF expression was remarkably elevated in the Inf-S and Inf-P group compared to the other groups (P < 0.05). In the epithelial cells of the fallopian tubes, LIFR expression was highest in the chronically inflamed group, followed by the tubal pregnancy group, outnumbering the control group (P < 0.05). More interestingly, an opposite expression trend of LIFR was observed in the stromal cells of the fallopian tubes among these groups (P < 0.05). Conclusion: Aberrant expression of LIF and LIFR might be associated with the occurrence of tubal pregnancy.

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Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Farquhar CM. Ectopic pregnancy. Lancet 2005; 366: 583591.
2. Sivalingam VN, Duncan WC, Kirk E, Shephard LA, Horne AW. Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care 2011; 37: 231240.
3. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L, Job-Spira N. Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol 2003; 157: 185194.
4. Varma R, Gupta J. Tubal ectopic pregnancy. Clin Evid (Online) 2009; 2009.
5. Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Köntgen F, Abbondanzo SJ. Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature 1992; 359: 7679.
6. Bhatt H, Brunet LJ, Stewart CL. Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci USA 1991; 88: 1140811412.
7. Senturk LM, Arici A. Leukemia inhibitory factor in human reproduction. Am J Reprod Immunol 1998; 39: 144151.
8. Salamonsen LA, Nie G, Dimitriadis E, Robb L, Findlay JK. Genes involved in implantation. Reprod Fertil Dev 2001; 13: 4149.
9. Keltz MD, Attar E, Buradagunta S, Olive DL, Kliman HJ, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human Fallopian tube. Am J Obstet Gynecol 1996; 175: 1611169.
10. Ji YF, Chen LY, Xu KH, Yao JF, Shi YF. Locally elevated leukemia inhibitory factor in the inflamed fallopian tube resembles that found in tubal pregnancy. Fertil Steril 2009; 91: 23082314.
11. Kiran G, Kiran H, Ertopcu K, Kilinc M, Ekerbicer HC, Vardar MA. Tuba uterina leukemia inhibitory factor concentration does not increase in tubal pregnancy: a preliminary study. Fertil Steril 2005; 83: 484486.
12. Wanggren K, Lalitkumar PG, Hambiliki F, Stabi B, GemzellDanielsson K, Stavreus-Evers A. Leukaemia inhibitory factor receptor and gp130 in the human Fallopian tube and endometrium before and after mifepristone treatment and in the human preimplantation embryo. Mol Hum Reprod 2007; 13: 391397.
13. Liang Y, Zhou Y, Jiang T, Zhang Z, Wang S, Wang Y. Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement. Angle Orthod 2011; 81: 600608.
14. Okamura Y, Nomoto S, Kanda M, Li Q, Nishikawa Y, Sugimoto H, Kanazumi N, Takeda S, Nakao A. Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array. Cancer Lett 2010; 289: 170177.
15. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med 2012; 18: 1511 1517.
16. Shaw JL, Dey SK, Critchley HO, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 2010; 16: 432444.
17. Hvid M, Baczynska A, Deleuran B, Fedder J, Knudsen HJ, Christiansen G, Birkelund S. Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol 2007; 9: 27952803.
18. Brown MA, Metcalf D, Gough NM. Leukemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation. Cytokine 1994; 6: 300309.
19. Derigs HG, Boswell HS. LIF mRNA expression is transcriptionally regulated in murine bone marrow stromal cells. Leukemia 1993; 7: 630634.
20. Hambartsoumian E. Leukemia inhibitory factor (LIF) production by human decidua and its relationship with pregnancy hormones. Gynecol Endocrinol 1998; 12: 1722.
21. Arici A, Engin O, Attar E, Olive DL. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. J Clin Endocrinol Metab 1995; 80: 19081915.
22. Vogiagis D, Marsh MM, Fry RC, Salamonsen LA. Leukemia inhibitory factor in human endometrium throughout the menstrual cycle. J Endocrinol 1996; 148: 95102.

APA	Li Y, SUN L, ZHAO D, OUYANG J, XIANG M (2015). Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. , 214 - 220.
Chicago	Li Yong,SUN Lizhou,ZHAO Denmei,OUYANG Jun,XIANG Mei Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. (2015): 214 - 220.
MLA	Li Yong,SUN Lizhou,ZHAO Denmei,OUYANG Jun,XIANG Mei Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. , 2015, ss.214 - 220.
AMA	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. . 2015; 214 - 220.
Vancouver	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. . 2015; 214 - 220.
IEEE	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M "Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence." , ss.214 - 220, 2015.
ISNAD	Li, Yong vd. "Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence". (2015), 214-220.

APA	Li Y, SUN L, ZHAO D, OUYANG J, XIANG M (2015). Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. Turkish Journal of Medical Sciences, 45(1), 214 - 220.
Chicago	Li Yong,SUN Lizhou,ZHAO Denmei,OUYANG Jun,XIANG Mei Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. Turkish Journal of Medical Sciences 45, no.1 (2015): 214 - 220.
MLA	Li Yong,SUN Lizhou,ZHAO Denmei,OUYANG Jun,XIANG Mei Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. Turkish Journal of Medical Sciences, vol.45, no.1, 2015, ss.214 - 220.
AMA	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. Turkish Journal of Medical Sciences. 2015; 45(1): 214 - 220.
Vancouver	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence. Turkish Journal of Medical Sciences. 2015; 45(1): 214 - 220.
IEEE	Li Y,SUN L,ZHAO D,OUYANG J,XIANG M "Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence." Turkish Journal of Medical Sciences, 45, ss.214 - 220, 2015.
ISNAD	Li, Yong vd. "Aberrant expression of leukemia inhibitory factor receptor (LIFR) and leukemia inhibitory factor (LIF) is associated with tubal pregnancy occurrence". Turkish Journal of Medical Sciences 45/1 (2015), 214-220.