Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model

Rana SIRMALI, (Dışkapı Yıldırım Beyazıt Araştırma Hastanesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)
Zeynep GİNİŞ, (Dışkapı Yıldırım Beyazıt Araştırma Hastanesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)
Mehmet SIRMALI, (Department of Surgery, Faculty of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA)
Okan SOLAK, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, Afyon, Türkiye)
Bengü ŞELİMAN, (Ankara Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Acil Servis Kliniği, Ankara, Türkiye)
Yetkin AĞAÇKIRAN, (Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, Ankara, Türkiye)
Namık DELİBAŞ (Bozok Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Yozgat, Türkiye)
Turkish Journal of Medical Sciences
5 1
Yıl: 2014 Cilt: 44 Sayı: 6 Sayfa Aralığı: 905 - 913 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model

Öz:
Background/aim: To analyze the protective activity of vitamin C on the lungs by assessing biochemical and histopathological analysis after performing an experimental isolated lung contusion model. Materials and methods: Fifty-four male Sprague-Dawley male rats were used. The rats were randomly separated into 4 groups. Vitamin C (200 mg/kg) was injected intraperitoneally 30 min after trauma. Blood samples were obtained for myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities and malondialdehyde (MDA) levels. Blood gas analysis and bronchoalveolar lavage was performed. The lung tissue was also extracted for histopathological examination. Results: The lung contusion enhanced MDA, SOD, CAT, and MPO and diminished GSH-Px. Vitamin C administration after the pulmonary contusion was found to diminish the level of MDA and the activities of SOD, CAT, and MPO and to enhance the level of GSH-Px (P < 0.05). Contusion-induced disrupted gas analysis and leukocyte infiltration were both resolved by the vitamin C. Conclusion: The present results indicate that vitamin C administration attenuated the oxidative damage and morphological changes induced by pulmonary contusion in an experimental rat study.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SIRMALI R, GİNİŞ Z, SIRMALI M, SOLAK O, ŞELİMAN B, AĞAÇKIRAN Y, DELİBAŞ N (2014). Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. , 905 - 913.
Chicago SIRMALI Rana,GİNİŞ Zeynep,SIRMALI Mehmet,SOLAK Okan,ŞELİMAN Bengü,AĞAÇKIRAN Yetkin,DELİBAŞ Namık Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. (2014): 905 - 913.
MLA SIRMALI Rana,GİNİŞ Zeynep,SIRMALI Mehmet,SOLAK Okan,ŞELİMAN Bengü,AĞAÇKIRAN Yetkin,DELİBAŞ Namık Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. , 2014, ss.905 - 913.
AMA SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. . 2014; 905 - 913.
Vancouver SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. . 2014; 905 - 913.
IEEE SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N "Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model." , ss.905 - 913, 2014.
ISNAD SIRMALI, Rana vd. "Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model". (2014), 905-913.
APA SIRMALI R, GİNİŞ Z, SIRMALI M, SOLAK O, ŞELİMAN B, AĞAÇKIRAN Y, DELİBAŞ N (2014). Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish Journal of Medical Sciences, 44(6), 905 - 913.
Chicago SIRMALI Rana,GİNİŞ Zeynep,SIRMALI Mehmet,SOLAK Okan,ŞELİMAN Bengü,AĞAÇKIRAN Yetkin,DELİBAŞ Namık Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish Journal of Medical Sciences 44, no.6 (2014): 905 - 913.
MLA SIRMALI Rana,GİNİŞ Zeynep,SIRMALI Mehmet,SOLAK Okan,ŞELİMAN Bengü,AĞAÇKIRAN Yetkin,DELİBAŞ Namık Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish Journal of Medical Sciences, vol.44, no.6, 2014, ss.905 - 913.
AMA SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish Journal of Medical Sciences. 2014; 44(6): 905 - 913.
Vancouver SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model. Turkish Journal of Medical Sciences. 2014; 44(6): 905 - 913.
IEEE SIRMALI R,GİNİŞ Z,SIRMALI M,SOLAK O,ŞELİMAN B,AĞAÇKIRAN Y,DELİBAŞ N "Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model." Turkish Journal of Medical Sciences, 44, ss.905 - 913, 2014.
ISNAD SIRMALI, Rana vd. "Vitamin C as an antioxidant: evaluation of its role on pulmonary contusion experimental model". Turkish Journal of Medical Sciences 44/6 (2014), 905-913.
Sayfa Oluşturulma Tarihi
23-04-2024 0:33

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