Serum fetuin-A levels in postmenopausal women with osteoporosis

Background/aim: One of the functions of fetuin-A is the restriction of formation and expansion of extraosseous hydroxyapatite crystals. The exact correlation of fetuin-A with bone mineral density (BMD) has not been clearly elucidated yet. In this study, we aimed to assess the relationship between BMD and fetuin-A in postmenopausal women. Materials and methods: Fifty postmenopausal women (25 with osteoporosis, 25 healthy controls) were included in the study. All participants were comparable for age and body mass index. None of the osteoporotic patients had received any medical treatment for osteoporosis. Serum fetuin-A levels were measured by ELISA method. Results: BMD scores of the groups were statistically significant (P < 0.001). Serum fetuin-A levels of the osteoporosis group were significantly lower compared to the control group (P = 0.009). Additionally, there was there was a mild to moderate positive correlation between fetuin-A and lumbar (r = 0.381, P = 0.06) and femoral (r = 0.143, P = 0.50) BMD in the osteoporotic group, though it did not reach statistical significance. Conclusion: Decreased fetuin-A levels in women with postmenopausal osteoporosis suggest that fetuin-A may have a role in the development of osteoporosis. Further studies are required to define the exact role of fetuin-A in bone metabolism.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZKAN E, Özkan H, BİLGİÇ S, ODABAŞI E, CAN N, AKGÜL E, YANMIŞ İ, YURTTAŞ Y, Kürklü M, BAŞBOZKURT M, Erbil M (2014). Serum fetuin-A levels in postmenopausal women with osteoporosis. , 985 - 988.
Chicago	ÖZKAN Esin,Özkan Hüseyin,BİLGİÇ Serkan,ODABAŞI Ersin,CAN NURAY,AKGÜL Emin Özgür,YANMIŞ İbrahim,YURTTAŞ Yüksel,Kürklü Mustafa,BAŞBOZKURT Mustafa,Erbil Mehmet Kemal Serum fetuin-A levels in postmenopausal women with osteoporosis. (2014): 985 - 988.
MLA	ÖZKAN Esin,Özkan Hüseyin,BİLGİÇ Serkan,ODABAŞI Ersin,CAN NURAY,AKGÜL Emin Özgür,YANMIŞ İbrahim,YURTTAŞ Yüksel,Kürklü Mustafa,BAŞBOZKURT Mustafa,Erbil Mehmet Kemal Serum fetuin-A levels in postmenopausal women with osteoporosis. , 2014, ss.985 - 988.
AMA	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M Serum fetuin-A levels in postmenopausal women with osteoporosis. . 2014; 985 - 988.
Vancouver	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M Serum fetuin-A levels in postmenopausal women with osteoporosis. . 2014; 985 - 988.
IEEE	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M "Serum fetuin-A levels in postmenopausal women with osteoporosis." , ss.985 - 988, 2014.
ISNAD	ÖZKAN, Esin vd. "Serum fetuin-A levels in postmenopausal women with osteoporosis". (2014), 985-988.

APA	ÖZKAN E, Özkan H, BİLGİÇ S, ODABAŞI E, CAN N, AKGÜL E, YANMIŞ İ, YURTTAŞ Y, Kürklü M, BAŞBOZKURT M, Erbil M (2014). Serum fetuin-A levels in postmenopausal women with osteoporosis. Turkish Journal of Medical Sciences, 44(6), 985 - 988.
Chicago	ÖZKAN Esin,Özkan Hüseyin,BİLGİÇ Serkan,ODABAŞI Ersin,CAN NURAY,AKGÜL Emin Özgür,YANMIŞ İbrahim,YURTTAŞ Yüksel,Kürklü Mustafa,BAŞBOZKURT Mustafa,Erbil Mehmet Kemal Serum fetuin-A levels in postmenopausal women with osteoporosis. Turkish Journal of Medical Sciences 44, no.6 (2014): 985 - 988.
MLA	ÖZKAN Esin,Özkan Hüseyin,BİLGİÇ Serkan,ODABAŞI Ersin,CAN NURAY,AKGÜL Emin Özgür,YANMIŞ İbrahim,YURTTAŞ Yüksel,Kürklü Mustafa,BAŞBOZKURT Mustafa,Erbil Mehmet Kemal Serum fetuin-A levels in postmenopausal women with osteoporosis. Turkish Journal of Medical Sciences, vol.44, no.6, 2014, ss.985 - 988.
AMA	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M Serum fetuin-A levels in postmenopausal women with osteoporosis. Turkish Journal of Medical Sciences. 2014; 44(6): 985 - 988.
Vancouver	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M Serum fetuin-A levels in postmenopausal women with osteoporosis. Turkish Journal of Medical Sciences. 2014; 44(6): 985 - 988.
IEEE	ÖZKAN E,Özkan H,BİLGİÇ S,ODABAŞI E,CAN N,AKGÜL E,YANMIŞ İ,YURTTAŞ Y,Kürklü M,BAŞBOZKURT M,Erbil M "Serum fetuin-A levels in postmenopausal women with osteoporosis." Turkish Journal of Medical Sciences, 44, ss.985 - 988, 2014.
ISNAD	ÖZKAN, Esin vd. "Serum fetuin-A levels in postmenopausal women with osteoporosis". Turkish Journal of Medical Sciences 44/6 (2014), 985-988.