TY  - JOUR
TI  - Detection of the frequency of PER-1 type extended-spectrum β-lactamase producing Acinetobacter baumannii clinical isolates in Turkey: a multicenter study
AB  - Background/aim: β-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type β-lactamase producing strains have been reported from various geographic locations; however, PER-1 type β-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type β-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect blaPER-1 genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P < 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type β-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.
AU  - ÖKSÜZ, LÜTFİYE
AU  - KURTOĞLU, Muhammet Güzel
AU  - KOÇOĞLU, Mücahide Esra
AU  - GÜL, MUSTAFA
AU  - BERKTAŞ, Mustafa
AU  - YAĞCI, Server
AU  - ÇİFTCİ, İHSAN HAKKI
AU  - AYYILDIZ, Ahmet
AU  - SESLİ ÇETİN, EMEL
AU  - AŞIK, Gülşah
AU  - SEYREK, Adnan
AU  - OZDEMIR, MEHMET
PY  - 2014
JO  - Turkish Journal of Medical Sciences
VL  - 44
IS  - 6
SN  - 1300-0144
SP  - 1041
EP  - 1046
DB  - TRDizin
UR  - http://search/yayin/detay/213220
ER  -