The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model

YUKSEL, Yasemin; ALBAYRAK, Serdar Baki; SEHITOGLU, Muserref Hilal; YAKA, Umut; Aras, Adem Bozkurt; GÜVEN, Mustafa; GÖMLEKSİZ, Cengiz; Tokmak, Mehmet; AKMAN, Tarık; COŞAR, Murat

The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model

Mehmet TOKMAK, (Medipol Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Muserref Hilal SEHITOGLU, (Çanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Çanakkale, Türkiye)

Yasemin YUKSEL, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Afyon, Türkiye)

Mustafa GÜVEN, (Çanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Çanakkale, Türkiye)

Tarık AKMAN, (Çanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Çanakkale, Türkiye)

Adem Bozkurt ARAS, (Çanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Çanakkale, Türkiye)

Umut YAKA, (Medipol Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Cengiz GÖMLEKSİZ, (Medipol Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Serdar Baki ALBAYRAK, (Medipol Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Murat COŞAR (Çanakkale Onsekiz Mart Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Çanakkale, Türkiye)

Turkish Neurosurgery

3 2

Yıl: 2017 Cilt: 27 Sayı: 1 Sayfa Aralığı: 124 - 132 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model

Öz:

AIm: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. mATERIAl and mEThODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESUlTS: Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONClUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tokmak M, SEHITOGLU M, YUKSEL Y, GÜVEN M, AKMAN T, Aras A, YAKA U, GÖMLEKSİZ C, ALBAYRAK S, COŞAR M (2017). The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. , 124 - 132.
Chicago	Tokmak Mehmet,SEHITOGLU Muserref Hilal,YUKSEL Yasemin,GÜVEN Mustafa,AKMAN Tarık,Aras Adem Bozkurt,YAKA Umut,GÖMLEKSİZ Cengiz,ALBAYRAK Serdar Baki,COŞAR Murat The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. (2017): 124 - 132.
MLA	Tokmak Mehmet,SEHITOGLU Muserref Hilal,YUKSEL Yasemin,GÜVEN Mustafa,AKMAN Tarık,Aras Adem Bozkurt,YAKA Umut,GÖMLEKSİZ Cengiz,ALBAYRAK Serdar Baki,COŞAR Murat The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. , 2017, ss.124 - 132.
AMA	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. . 2017; 124 - 132.
Vancouver	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. . 2017; 124 - 132.
IEEE	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M "The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model." , ss.124 - 132, 2017.
ISNAD	Tokmak, Mehmet vd. "The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model". (2017), 124-132.

APA	Tokmak M, SEHITOGLU M, YUKSEL Y, GÜVEN M, AKMAN T, Aras A, YAKA U, GÖMLEKSİZ C, ALBAYRAK S, COŞAR M (2017). The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery, 27(1), 124 - 132.
Chicago	Tokmak Mehmet,SEHITOGLU Muserref Hilal,YUKSEL Yasemin,GÜVEN Mustafa,AKMAN Tarık,Aras Adem Bozkurt,YAKA Umut,GÖMLEKSİZ Cengiz,ALBAYRAK Serdar Baki,COŞAR Murat The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery 27, no.1 (2017): 124 - 132.
MLA	Tokmak Mehmet,SEHITOGLU Muserref Hilal,YUKSEL Yasemin,GÜVEN Mustafa,AKMAN Tarık,Aras Adem Bozkurt,YAKA Umut,GÖMLEKSİZ Cengiz,ALBAYRAK Serdar Baki,COŞAR Murat The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery, vol.27, no.1, 2017, ss.124 - 132.
AMA	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery. 2017; 27(1): 124 - 132.
Vancouver	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery. 2017; 27(1): 124 - 132.
IEEE	Tokmak M,SEHITOGLU M,YUKSEL Y,GÜVEN M,AKMAN T,Aras A,YAKA U,GÖMLEKSİZ C,ALBAYRAK S,COŞAR M "The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model." Turkish Neurosurgery, 27, ss.124 - 132, 2017.
ISNAD	Tokmak, Mehmet vd. "The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model". Turkish Neurosurgery 27/1 (2017), 124-132.