Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity

DEMİREL, Sibel; BİNGÖL KIZILTUNÇ, Pınar; BATIOĞLU, Figen; ÖZMERT, Emin

Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity

Sibel DEMİREL, (Ankara Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Pınar BİNGÖL KIZILTUNÇ, (Ankara Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Figen BATIOĞLU, (Ankara Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Emin ÖZMERT (Ankara Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Retina-Vitreus

12 0

Yıl: 2016 Cilt: 24 Sayı: 2 Sayfa Aralığı: 119 - 123 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity

Öz:

Amaç: Geç başlangıçlı foveomaküler vitelliform distrofinin, fundus otoflöresans (FOF) ve optik koherens tomografi (OKT) bulgularını tanımlamak ve bunların en iyi düzeltilmiş görme keskinliği (EİDGK) ile korelasyonunu değerlendirmek. Gereç ve Yöntem: 39 gözün bulguları retrospektif olarak değerlendirildi. EİDGK, fundus muayene, OKT ve FOF bulguları kaydedildi. Bulgular: Olguların 27'si (%69,2) yaşa bağlı makula dejenerasyonu (YBMD) tanısı ile kliniğimize refere edilmişti. Başlangıç muayenede 34 göz (%87,1) vitelliform, 5 göz (%12,9) diğer evrelerde idi. Son muayenede 2 göz (%5,1) vitelliform evreden atrofik evreye ilerledi. FOF görüntülemede, vitelliform evrede; iyi sınırlı, yüksek otoflöresan sinyal, psödohipopiyon evresinde; horizontal olarak seviye veren artmış hiperflöresans, vitellirüptif evrede; düzensiz hiperflöresans, atrofik evrede ise otoflöresansda kayıp izlendi. Vitelliform evredeki gözlerin; %30,7'i yamalı, %28,2'i fokal, %15,3'ü halka şeklinde, %10,2'si ise yuvarlak pattern özellikleri gösteriyordu. EİDGK ve FOF patternleri arasında ilişki gösterilemedi. OKT görüntülemede, EİDGK ile lezyonun maksimal yüksekliği arasında negatif korelasyon saptandı. Fakat EİDGK ile lezyonun genişliği ya da santral makula kalınlığı arasında ilişki gösterilemedi. IS/OS tabakasının hasarı ile EİDGK arasında negatif korelasyon vardı. Subfoveal sıvı, RPE düzensizliği ve EİDGK arasında ilişki gösterilemedi. Tartışma: AVD, yaşa bağlı makula dejenerasyonu ayırıcı tanısında düşünülmesi gereken en önemli hastalıktır. FOF ve OCT görüntüleme AVD tanısının doğrulanmasında en temel görüntüleme teknikleridir. Görme keskinliği prognozunu tahmin etmede OCT bulguları FOF patternlerine göre daha faydalıdır.

Anahtar Kelime:

Konular: Göz Hastalıkları

Öz:

Purpose: To describe the fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings at adult-onset foveomacular vitelliform dystrophy (AOFVD) and to evaluate their correlation with best corrected visual acuity (BCVA). Material and Methods: The records of 39 eyes were evaluated retrospectively. The BCVA, the findings of fundus examination, OCT and FAF images were noted.Results: Twenty seven (69.2%) of all patients were referred with the diagnosis of age related macular degeneration (AMD). At initial examination 34 (87.1%) eyes presented vitelliform stage and 5 (12.9%) eyes presented the other stages. At last visit 2 (5.1%) eyes progressed to the atrophic stage from the vitelliform stage. At FAF images; we detected well-circumscribed, very high autofluorescence signal in the vitelliform stage, increased autofluorescence with horizontally level in the pseudohypopyon stage, irregular hyperautofluorescence in the vitelliruptive stage and loss of autofluorescence in the atrophic stage. At vitelliform stage 30.7% had patchy, 28.2% focal, 15.3% ring-like, 10.2% round-shape pattern. The correlation between BCVA and FAF patterns could not be shown. At OCT findings; there was a negative correlation between the maximal thickness of the lesion and BCVA, but the correlation between BCVA and maximal width of lesion and central macular thickness could not be shown. There was a negative correlation between presence of IS/OS interface disruption and BCVA. A correlation between subfoveal fluid, RPE alterations and BCVA could not be shown. Conclusions: AOFVD is the most important disorder in the differential diagnosis of AMD. FAF and OCT imaging techniques are useful for confirming the diagnosis of AOFVD. OCT findings are more useful than FAF patterns of the lesions for predicting visual acuity prognosis.

Anahtar Kelime:

Konular: Göz Hastalıkları

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

Gass JD. A clinicopathologic study of a peculiar foveomacular dystrophy. Trans Am Ophthalmol Soc 1974;72:139-56.
Vine AK, Schatz H. Adult-onset foveomacular pigment epithelial dystrophy. Am J Ophthalmol 1980; 89:680-691.
Bloom LH, Swanson DE, Bird AC. Adult vitelliform macular degenera- tion. The British journal of ophthalmology 1981;65:800-1.
Fishman GA, Trimble S, Rabb MF, et al. Pseudovitelliform macular degeneration. Arch Ophthalmol 1977;95:73-6.
Chung JE, Spaide RF. Fundus autofluorescence and vitelliform macular dystrophy. Arch Ophthalmol 2004;122:1078-9.
Nandakumar N, Buzney S, Weiter JJ. Lipofuscin and the principles of fundus autofluorescence: a review. Semin Ophthalmol 2012;27:202-6.
Patrinely JR, Lewis RA, Font RL. Foveomacular vitelliform dystrophy, adult type. A clinicopathologic study including electron microscopic observations. Ophthalmology 1985;92:1712-8.
Boyer NP, Tang PH, Higbee D, et al. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol 2012;88:1373-7.
Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epit- helium lipofuscin characteristics. Investigative ophthalmology&visual science 1995;36:718-729.
Puche N, Querques G, Benhamou N, et al. High-resolution spectral domain optical coherence tomography features in adult onset foveo- macular vitelliform dystrophy. The British journal of ophthalmology 2010;94:1190-6.
Parodi MB, Iacono P, Pedio M, et al. Autofluorescence in adult-onset foveomacular vitelliform dystrophy. Retina 2008;28:801-7.
Furino C, Boscia F, Cardascia N, et al. Fundus autofluorescence, optical coherence tomography and visual acuity in adult-onset foveomacular dystrophy. Ophthalmologica 2008; 222:240-4.
Querques G, Forte R, Querques L, et al. Natural course of adult-onset foveomacular vitelliform dystrophy: a spectral-domain optical coheren- ce tomography analysis. Am J Ophthalmol 2011;152:304-13.
Epstein GA, Rabb MF. Adult vitelliform macular degeneration: di- agnosis and natural history. The British journal of ophthalmology 1980;64:733-40.
Do P, Ferrucci S. Adult-onset foveomacular vitelliform dystrophy. Op- tometry 2006;77:156-66.
Renner AB, Tillack H, Kraus H, et al. Morphology and functional charac- teristics in adult vitelliform macular dystrophy. Retina 2004;24:929-39.
Querques G, Bux AV, Prato R, et al. Correlation of visual function im- pairment and optical coherence tomography findings in patients with adult-onset foveomacular vitelliform macular dystrophy. Am J Oph- thalmol 2008;146:135-42.
Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Investigative ophthalmology&visual science 2000;41:1981-9.
Pierro L, Tremolada G, Introini U, et al. Optical coherence tomography findings in adult-onset foveomacular vitelliform dystrophy. Am J Oph- thalmol 2002;134:675-80.
Ota M, Tsujikawa A, Murakami T, et al. Association between integrity of foveal photoreceptor layer and visual acuity in branch retinal vein occlusion. The British journal of ophthalmology 2007;91:1644-9.
Shin HJ, Chung H, Kim HC. Association between integrity of foveal photoreceptor layer and visual outcome in retinal vein occlusion. Acta ophthalmologica 2011;89:35-40.
Maheshwary AS, Oster SF, Yuson RM, et al. The association between percent disruption of the photoreceptor inner segment-outer segment junction and visual acuity in diabetic macular edema. Am J Ophthalmol 2010;150:63-7.
Hayashi H, Yamashiro K, Tsujikawa A, et al. Association between fove- al photoreceptor integrity and visual outcome in neovascular age-rela- ted macular degeneration. Am J Ophthalmol 2009;148:83-9.
Benhamou N, Messas-Kaplan A, Cohen Y, et al. Adult-onset fo- veomacular vitelliform dystrophy with OCT 3. Am J Ophthalmol 2004;138:294-6.
Arnold JJ, Sarks JP, Killingsworth MC, et al. Adult vitelliform macular degeneration: a clinicopathological study. Eye 2003;17:717-26.

APA	DEMİREL S, BİNGÖL KIZILTUNÇ P, BATIOĞLU F, ÖZMERT E (2016). Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. , 119 - 123.
Chicago	DEMİREL Sibel,BİNGÖL KIZILTUNÇ Pınar,BATIOĞLU Figen,ÖZMERT Emin Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. (2016): 119 - 123.
MLA	DEMİREL Sibel,BİNGÖL KIZILTUNÇ Pınar,BATIOĞLU Figen,ÖZMERT Emin Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. , 2016, ss.119 - 123.
AMA	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. . 2016; 119 - 123.
Vancouver	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. . 2016; 119 - 123.
IEEE	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E "Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity." , ss.119 - 123, 2016.
ISNAD	DEMİREL, Sibel vd. "Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity". (2016), 119-123.

APA	DEMİREL S, BİNGÖL KIZILTUNÇ P, BATIOĞLU F, ÖZMERT E (2016). Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. Retina-Vitreus, 24(2), 119 - 123.
Chicago	DEMİREL Sibel,BİNGÖL KIZILTUNÇ Pınar,BATIOĞLU Figen,ÖZMERT Emin Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. Retina-Vitreus 24, no.2 (2016): 119 - 123.
MLA	DEMİREL Sibel,BİNGÖL KIZILTUNÇ Pınar,BATIOĞLU Figen,ÖZMERT Emin Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. Retina-Vitreus, vol.24, no.2, 2016, ss.119 - 123.
AMA	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. Retina-Vitreus. 2016; 24(2): 119 - 123.
Vancouver	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity. Retina-Vitreus. 2016; 24(2): 119 - 123.
IEEE	DEMİREL S,BİNGÖL KIZILTUNÇ P,BATIOĞLU F,ÖZMERT E "Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity." Retina-Vitreus, 24, ss.119 - 123, 2016.
ISNAD	DEMİREL, Sibel vd. "Adult-Onset Foveomacular Vitelliform Dystrophy: Diagnosis and Correlation Fundus Autofluorescence, Optical Coherence Tomography Features and Visual Acuity". Retina-Vitreus 24/2 (2016), 119-123.