TY  - JOUR
TI  - Drug- and herb-induced liver injury: A case series from a single center
AB  - Background/Aims: Drug-induced liver injury (DILI) is common worldwide and has a potentially fatal outcome. It accounts for more than half of the cases of acute liver failure in the United States. Herb-induced liver injury (HILI) is a less documented condition but a growing problem. We present here the clinical characteristics and outcome of patients with drug- and herb-induced liver injury from our center. Materials and Methods: In this 4-year retrospective study, 82 patients in whom there was a causal or highly probable relationship between herbal medicine or drug use and liver disease are presented. Results: The mean age of patients was 43.1±14.8 years; sexual distribution was 53 females and 29 males. The major cause of hepatotoxicity was drugs (87.8%), with herbal medicine accounting for 12.2%. The leading causative agents were nonsteroidal anti-inflammatory drugs (NSAIDs) (23.1%), followed by antibiotics (19.5%). The pattern of hepatotoxicity was hepatocellular in 35 patients (42.6%), mixed in 28 (34.1%), and cholestatic in 19 patients (23.1%). Teucrium polium (known popularly as felty germander), which is a traditionally used herbal medicine of the Labiatae family in our region, was the most common cause of herb-induced liver injury and responsible in 7 of 10 herbal hepatotoxic cases. Acute liver failure developed in 3 patients (two patients related with flurbiprofen and diclofenac and one patient due to an isoniazid-rifampicin combination). Conclusion: Antibiotics and NSAIDs were the most common etiologic agents for drug-induced liver injury. Surprisingly, herbs follow these groups of drugs and must be questioned more carefully.
AU  - KADAYIFÇI, Abdurrahman
AU  - KORUK, İrfan
AU  - Koruk, Mehmet
AU  - DAĞ, Muhammed Sait
AU  - ÖZTÜRK, ZEYNEL ABİDİN
AU  - Turkbeyler, Ibrahim Halil
AU  - SAVAŞ, Muhammet Cemil
AU  - AYDINLI, Musa
PY  - 2014
JO  - Turkish Journal of Gastroenterology
VL  - 25
IS  - 1
SN  - 1300-4948
SP  - 41
EP  - 45
DB  - TRDizin
UR  - http://search/yayin/detay/221232
ER  -