THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT

RIZA KOLBAŞ, Ali; Tan, Cagman; ER, Nuray

THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT

Çağman TAN, (Hacettepe Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İmmünoloji Ünitesi, Ankara, Türkiye)

Ali RIZA KOLBAŞ, (Hacettepe Üniversitesi, Diş Hekimliği Fakültesi, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Nuray ER (Hacettepe Üniversitesi, Diş Hekimliği Fakültesi, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı, Ankara, Türkiye)

Clinical Dentistry and Research

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Yıl: 2017 Cilt: 41 Sayı: 1 Sayfa Aralığı: 36 - 42 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT

Öz:

Giriş ve Amaç: Peri-implant hastalıkların multi faktöriyel doğası sebebiyle, peri-implantitis ve peri-implant mukositis tedavisinde standart bir tedavi protokolü oluşturulamamaktadır. Bu çalışmanın amacı, peri-implantitisli ve sağlıklı dental implantların peri-implant oluğu sıvısındaki (PIOS) IL-8 düzeylerini inceleyerek, IL-8'in periimplantitisteki rolünü tespit etmektir. Materyal ve Yöntem: Çalışmaya 6 hastada bulunan 6 sağlıklı ve 6 peri-implantitisli toplam 12 implant dahil edildi. PIOS IL-8 düzeyleri Luminex 200TM Human Cytokine Plex kiti kullanılarak değerlendirildi. Bulgular: PIOS IL-8 düzeylerinde peri-implantitis ve kontrol grupları arasında anlamlı farklar olduğu görüldü. Peri-implantitis grubunda PİOS IL-8 seviyeleri önemli derecede yüksekti (p=0.03). PIOS IL-8 düzeyleri ve peri-implant sondlama derinliği (MB, ML, DB, DL) arasında sondlama derinliği arttıkça IL-8 seviyelerinin de arttığı gözlendi.. Sonuç: PIOS IL-8 düzeylerinin peri-implantitiste arttığını gösteren bulgularımız, IL-8'in peri-implantitisin etyopatogenezinde önemli rol oynadığına işaret etmektedir Sonuç olarak, peri-implantitisin patogenezinde sitokinlerin rolünün anlaşılması, hastalığın önlenmesi ve yeni tedavi stratejilerinin geliştirilmesinde önemli katkılar sağlayabilir.

Anahtar Kelime:

Konular: Diş Hekimliği

PERI-IMPLANTİTİS VE SAĞLIKLI DENTAL İMPLANTLARDAKİ PERİ-İMPLANT OLUĞU SIVISINDA IL-8 DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Öz:

Background and Aim: None of the therapeutic strategies has proven to be highly effective against peri-implantitis, and a gold standard for the treatment of peri-implantitis and peri-implant mucositis has yet to be defined. The aim of this study was to determine the role of IL-8 in peri-implantitis pathogenesis by analysis the IL-8 levels in peri-implant crevicular fluid (PICF) of peri-implantitis and healthy dental implants. Material and Methods: A total of 12 implants; 6 healthy dental implants and 6 implants with peri-implantitis found in 6 patients were included in this study. IL-8 levels of the obtained PICF samples were evaluated with Luminex 200TM by using Human Cytokin Plex kit. Results: It was shown that there was significant differences between the PICF IL-8 levels of healthy dental implants and peri-implantitis groups. IL-8 levels were significantly higher in peri-implantitis group (p=0.03). It has been observed that IL-8 levels elevated as probing depth increased. Conclusion: Increased IL-8 levels , indicate that cytokines play and important role in the pathogenesis of IL-8 in periimplantitis. In conclusion, understanding the role of cytokines in pathogenesis of peri-implantitis may provide important contributions to the development of disease prevention and new treatment strategies.

Anahtar Kelime:

Konular: Diş Hekimliği

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tan C, RIZA KOLBAŞ A, ER N (2017). THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. , 36 - 42.
Chicago	Tan Cagman,RIZA KOLBAŞ Ali,ER Nuray THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. (2017): 36 - 42.
MLA	Tan Cagman,RIZA KOLBAŞ Ali,ER Nuray THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. , 2017, ss.36 - 42.
AMA	Tan C,RIZA KOLBAŞ A,ER N THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. . 2017; 36 - 42.
Vancouver	Tan C,RIZA KOLBAŞ A,ER N THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. . 2017; 36 - 42.
IEEE	Tan C,RIZA KOLBAŞ A,ER N "THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT." , ss.36 - 42, 2017.
ISNAD	Tan, Cagman vd. "THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT". (2017), 36-42.

APA	Tan C, RIZA KOLBAŞ A, ER N (2017). THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. Clinical Dentistry and Research, 41(1), 36 - 42.
Chicago	Tan Cagman,RIZA KOLBAŞ Ali,ER Nuray THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. Clinical Dentistry and Research 41, no.1 (2017): 36 - 42.
MLA	Tan Cagman,RIZA KOLBAŞ Ali,ER Nuray THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. Clinical Dentistry and Research, vol.41, no.1, 2017, ss.36 - 42.
AMA	Tan C,RIZA KOLBAŞ A,ER N THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. Clinical Dentistry and Research. 2017; 41(1): 36 - 42.
Vancouver	Tan C,RIZA KOLBAŞ A,ER N THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT. Clinical Dentistry and Research. 2017; 41(1): 36 - 42.
IEEE	Tan C,RIZA KOLBAŞ A,ER N "THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT." Clinical Dentistry and Research, 41, ss.36 - 42, 2017.
ISNAD	Tan, Cagman vd. "THE ANALYSIS OF THE IL-8 LEVELS IN PERI-IMPLANT CREVICULAR FLUID OF PERI-IMPLANTITIS AND HEALTHY DENTAL IMPLANT". Clinical Dentistry and Research 41/1 (2017), 36-42.