Yıl: 2017 Cilt: 33 Sayı: 2 Sayfa Aralığı: 62 - 68 Metin Dili: İngilizce DOI: 10.5152/turkjsurg.2017.3337 İndeks Tarihi: 29-07-2022

Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice

Öz:
Objective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen freeradicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), whichis a potent exogenous free-radical scavenger and antioxidant.Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of MedicineResearch and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino ratswere used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group(sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in thesecond group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastriclavage for 10 days in the third group.Results: Biochemical values revealed a statistically significant difference between Group I and the others. There wasno difference between Group II and III regarding biochemical values. There was a statistically significant difference,however, between Group II and III with regards to nitric oxide levels. There was a statistically significant differencebetween Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage.Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage causedby oxygen free-radicals.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SAVDAN M, CAKIR M, Vatansev H, KÜÇÜKKARTALLAR T, TEKIN A, TAVLI Ş (2017). Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. , 62 - 68. 10.5152/turkjsurg.2017.3337
Chicago SAVDAN Mervan,CAKIR Murat,Vatansev Hüsamettin,KÜÇÜKKARTALLAR Tevfik,TEKIN AHMET,TAVLI Şakir Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. (2017): 62 - 68. 10.5152/turkjsurg.2017.3337
MLA SAVDAN Mervan,CAKIR Murat,Vatansev Hüsamettin,KÜÇÜKKARTALLAR Tevfik,TEKIN AHMET,TAVLI Şakir Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. , 2017, ss.62 - 68. 10.5152/turkjsurg.2017.3337
AMA SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. . 2017; 62 - 68. 10.5152/turkjsurg.2017.3337
Vancouver SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. . 2017; 62 - 68. 10.5152/turkjsurg.2017.3337
IEEE SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş "Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice." , ss.62 - 68, 2017. 10.5152/turkjsurg.2017.3337
ISNAD SAVDAN, Mervan vd. "Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice". (2017), 62-68. https://doi.org/10.5152/turkjsurg.2017.3337
APA SAVDAN M, CAKIR M, Vatansev H, KÜÇÜKKARTALLAR T, TEKIN A, TAVLI Ş (2017). Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery, 33(2), 62 - 68. 10.5152/turkjsurg.2017.3337
Chicago SAVDAN Mervan,CAKIR Murat,Vatansev Hüsamettin,KÜÇÜKKARTALLAR Tevfik,TEKIN AHMET,TAVLI Şakir Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery 33, no.2 (2017): 62 - 68. 10.5152/turkjsurg.2017.3337
MLA SAVDAN Mervan,CAKIR Murat,Vatansev Hüsamettin,KÜÇÜKKARTALLAR Tevfik,TEKIN AHMET,TAVLI Şakir Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery, vol.33, no.2, 2017, ss.62 - 68. 10.5152/turkjsurg.2017.3337
AMA SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery. 2017; 33(2): 62 - 68. 10.5152/turkjsurg.2017.3337
Vancouver SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery. 2017; 33(2): 62 - 68. 10.5152/turkjsurg.2017.3337
IEEE SAVDAN M,CAKIR M,Vatansev H,KÜÇÜKKARTALLAR T,TEKIN A,TAVLI Ş "Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice." Turkish Journal of Surgery, 33, ss.62 - 68, 2017. 10.5152/turkjsurg.2017.3337
ISNAD SAVDAN, Mervan vd. "Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice". Turkish Journal of Surgery 33/2 (2017), 62-68. https://doi.org/10.5152/turkjsurg.2017.3337