Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children

binay, cigdem; GÜZEL, Savaş; SAMANCI, NEDİM; PAKETÇI, CEM

Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children

Çiğdem BİNAY, (Tekirdağ Çorlu Devlet Hastanesi, Pediatrik Endokrinoloji Kliniği, Tekirdağ, Türkiye)

CEM PAKETÇI, (Namık Kemal Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Tekirdağ, Türkiye)

Savaş GÜZEL, (Namık Kemal Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Tekirdağ, Türkiye)

Nedim SAMANCI (Namık Kemal Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Tekirdağ, Türkiye)

Journal of Clinical Research in Pediatric Endocrinology

2 0

Yıl: 2017 Cilt: 9 Sayı: 2 Sayfa Aralığı: 124 - 131 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children

Öz:

Objective: Irisin and oxytocin can affect energy homeostasis and it has been suggested that they may play an important role in reducing obesity and diabetes. In this study, we aimed to determine the relationship between metabolic parameters (including irisin and oxytocin levels) and anthropometric parameters in obese children.Methods: Ninety obese children (mean age, 13.85±1.63 years) and 30 healthy controls (mean age, 14.32±1.58 years) were enrolled in this study. Anthropometric and laboratory parameters (glucose, insulin, lipid, oxytocin, and irisin levels) were analyzed. The serum irisin and oxytocin levels were measured by enzyme-linked immunosorbent assay. Bioelectrical impedance was used to determine body composition.Results: Irisin level was higher in the patients than in the controls (p=0.018), and this higher irisin level was correlated with increased systolic blood pressure, body mass index, waist/hip ratio, fat percentage, fat mass, glucose level, insulin level, and homeostasis model assessment of insulin resistance. Serum oxytocin level was significantly decreased in obese children compared to the controls (p=0.049). Also, among the 60 obese patients, oxytocin level was significantly lower in patients with than in those without metabolic syndrome (8.65±2.69 vs. 10.87±5.93 ng/L, respectively), while irisin levels were comparable (p=0.049 and p=0.104, respectively). There were no statistically significant relationships between oxytocin or irisin levels and lipid levels (p>0.05).Conclusion: Obese children had significantly higher irisin levels than the healthy controls. Additionally, this study shows for the first time that oxytocin level is significantly lower in obese compared with non-obese children and also lower in obese children with metabolic syndrome compared to those without.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Novelle MG, Contreras C, Romero-Picó A, López M, Diéguez C. Irisin, two years later. Int J Endocrinol 2013;2013:746281. Epub 2013 Nov 5
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hİjlund K, Gygi SP, Spiegelman BM. A PGC1--dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-468.
Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005;1:361-370.
Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, Ricart W, Fernández-Real JM. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 2013;98:769- 778. Epub 2013 Feb 22
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM . Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376. Epub 2012 Jul 12
Timmons JA, Baar K, Davidsen PK, Atherton PJ. Is irisin a human exercise gene? Nature 2012;488:9-10.
Huh, JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012;61:1725-1738. Epub 2012 Sep 25.
Lecker SH, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, Schulze PC, Forman DE. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail 2012;5:812-818. Epub 2012 Sep 20
Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ. Irisin- immunoreactivity in neural and non-neural cells of the rodent. Neuroscience 2013;240:155-162. Epub 2013 Mar 5
Lam TK, Schwartz GJ, Rossetti L. Hypothalamic sensing of fatty acids. Nat Neurosci 2005;8:579-584.
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999;98:115-124.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol 2005;3:e101. Epub 2005 Mar 15
Ma D, Li S, Lucas EK, Cowell RM, Lin JD. Neuronal inactivation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) protects mice from diet-induced obesity and leads to degenerative lesions. J Biol Chem 2010;285:39087-39095. Epub 2010 Oct 13
Altirriba J, Poher AL, Rohner-Jeanrenaud F. Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity. Front Endocrinol (Lausanne) 2015;6:119.
Blevins JE, Ho JM. Role of oxytocin signaling in the regulation of body weight. Rev Endocr Metab Disord 2013;14:311-329.
Qian W, Zhu T, Tang B, Yu S, Hu H, Sun W, Pan R, Wang J, Wang D, Yang L, Mao C, Zhou L, Yuan G. Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients. J Clin Endocrinol Metab 2014;99:4683-4689.
Yuan G, Qian W, Pan R, Jia J, Jiang D, Yang Q, Wang S, Liu Y, Yu S, Hu H, Sun W, Ye J, Mao C, Zhuang R, Zhou L. Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome. Endocr J 2016;63:655-662. Epub 2016 May 24
Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303.
Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S; International Diabetes Federation Task Force on Epidemiology and Prevention of Diabetes. The metabolic syndrome in children and adolescents. Lancet 2007;369:2059-2061.
Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:1635-1641.
World Health Organization (WHO): Waist circumference and waist-hip ratio: report of a WHO expert consultation. Geneva, 8-11 December 2008. Geneva, Switzerland: WHO; 2011.
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-576.
Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M. Insulin resistance in obese children and adolescents: HOMA-IR cut- off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol 2010;2:100-106. Epub 2010 Aug 2
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides 2013;39:125-130. Epub 2012 Dec 3
Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE, Tsoukas MA, Geladari EV, Huh JY, Dincer F, Davis CR, Crowell JA, Mantzoros CS. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 2013;98:4899-4907. Epub 2013 Sep 20
Yan B, Shi X, Zhang H, Pan L, Ma Z, Liu S, Liu Y, Li X, Yang S, Li Z. Association of serum irisin with metabolic syndrome in obese Chinese adults. PLoS One 2014;9:e94235.
Crujeiras AB, Zulet MA, Lopez-Legarrea P, de la Iglesia R, Pardo M, Carreira MC, Martínez JA, Casanueva FF. Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients. Metabolism 2014;63:520-531. Epub 2013 Dec 18
Staiger H, Böhm A, Scheler M, Berti L, Machann J, Schick F, Machicao F, Fritsche A, Stefan N, Weigert C, Krook A, Häring HU, de Angelis MH. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'Browning' factor irisin, determines insulin sensitivity. PLoS One 2013;8:e61903.
Palacios-González B, Vadillo-Ortega F, Polo-Oteyza E, Sánchez T, Ancira-Moreno M, Romero-Hidalgo S, Meráz N, Antuna-Puente B. Irisin levels before and after physical activity among school-age children with different BMI: a direct relation with leptin. Obesity (Silver Spring) 2015;23:729-732.
Reinehr T, Elfers C, Lass N, Roth CL. Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis. J Clin Endocrinol Metab 2015;100:2123-2130. Epub 2015 Mar 17
Çatlı G, Küme T, Tuhan HÜ, Anık A, Çalan ÖG, Böber E, Abacı A. Relation of serum irisin level with metabolic and antropometric parameters in obese children. J Diabetes Complications 2016;30:1560-1565. Epub 2016 Jul 28
Crujeiras AB, Pardo M, Arturo RR, Navas-Carretero S, Zulet MA, Martínez JA, Casanueva FF. Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am J Hum Biol 2014;26:198-207. Epub 2013 Dec 5
Hojlund K, Bostrom P. Irisin in obesity and type 2 diabetes. J Diabetes Complications 2013;27:303-304. Epub 2013 May 7
Padmalayam I, Suto M. Role of adiponectin in the metabolic syndrome: current perspectives on its modulation as a treatment strategy. Curr Pharm Des 2013;19:5755-5763.
Swick AG, Orena S, O'Connor A. Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism 2013;62:1070-1073. Epub 2013 Apr 8
Al-Daghri NM, Alkharfy KM, Rahman S, Amer OE, Vinodson B, Sabico S, Piya MK, Harte AL, McTernan PG, Alokail MS, Chrousos GP. Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects. Eur J Clin Invest 2014;44:119-124. Epub 2013 Dec 6
Zhang HJ, Zhang XF, Ma ZM, Pan LL, Chen Z, Han HW, Han CK, Zhuang XJ, Lu Y, Li XJ, Yang SY, Li XY. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol 2013;59: 557-562. Epub 2013 May 9
Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, Kim JG, Lee IK, Park KG. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 2013;100:96-101. Epub 2013 Jan 29
Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, Tavintharan S, Sum CF, Lim SC. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications 2013;27:365-369. Epub 2013 Apr 22
Erickson HP. Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor? Adipocyte 2013;2:289-293. Epub 2013 Aug 19
Blüher S, Panagiotou G, Petroff D, Markert J, Wagner A, Klemm T, Filippaios A, Keller A, Mantzoros CS. Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity (Silver Spring) 2014;22:1701-1708. Epub 2014 Mar 25
Stock S, Granstrom L, Backman L, Matthiesen AS, Uvnas-Moberg K. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Int J Obes 1989;13:213-222.
Coiro V, Passeri M, Davoli C, d'Amato L, Gelmini G, Fagnoni F, Schianchi L, Bentivoglio M, Volpi R, Chiodera P. Oxytocin response to insulin- induced hypoglycemia in obese subjects before and after weight loss. J Endocrinol Invest 1988;11:125-128.
Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500-503. Epub 2005 Mar 1
Cai D, Purkayastha S. A New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and Diabetes. Drug Discov Today Dis Mech 2013;10: 63-68.
Blevins JE, Graham JL, Morton GJ, Bales KL, Schwartz MW, Baskin DG, Havel PJ. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose- fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 2015;308:431-438. Epub 2014 Dec 24
Camerino C. Low sympathetic tone and obese phenotype in oxytocin- deficient mice. Obesity (Silver Spring) 2009;17:980-984. Epub 2009 Feb 26
Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport 2008;19:951-955.
Blechman J, Amir-Zilberstein L, Gutnick A, Ben-Dor S, Levkowitz G. The metabolic regulator PGC-1? directly controls the expression of the hypothalamic neuropeptide oxytocin. J Neurosci 2011;31:14835- 14840.
Zhang H, Wu C, Chen Q, Chen X, Xu Z, Wu J, Cai D. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One 2013;8:e61477.
Jankowski M, Broderick TL, Gutkowska J. Oxytocin and cardioprotection in diabetes and obesity. BMC Endocr Disord 2016;16:34.
Jankowski M, Bissonauth V, Gao L, Gangal M, Wang D, Danalache B, Wang Y, Stoyanova E, Cloutier G, Blaise G, Gutkowska J. Anti- inflammatory effect of oxytocin in rat myocardial infarction. Basic Res Cardiol 2010;105:205-218. Epub 2009 Dec 12
Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med 2008;14:741-751. Epub 2008 Sep 17

APA	binay c, PAKETÇI C, GÜZEL S, SAMANCI N (2017). Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. , 124 - 131.
Chicago	binay cigdem,PAKETÇI CEM,GÜZEL Savaş,SAMANCI NEDİM Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. (2017): 124 - 131.
MLA	binay cigdem,PAKETÇI CEM,GÜZEL Savaş,SAMANCI NEDİM Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. , 2017, ss.124 - 131.
AMA	binay c,PAKETÇI C,GÜZEL S,SAMANCI N Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. . 2017; 124 - 131.
Vancouver	binay c,PAKETÇI C,GÜZEL S,SAMANCI N Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. . 2017; 124 - 131.
IEEE	binay c,PAKETÇI C,GÜZEL S,SAMANCI N "Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children." , ss.124 - 131, 2017.
ISNAD	binay, cigdem vd. "Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children". (2017), 124-131.

APA	binay c, PAKETÇI C, GÜZEL S, SAMANCI N (2017). Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. Journal of Clinical Research in Pediatric Endocrinology, 9(2), 124 - 131.
Chicago	binay cigdem,PAKETÇI CEM,GÜZEL Savaş,SAMANCI NEDİM Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. Journal of Clinical Research in Pediatric Endocrinology 9, no.2 (2017): 124 - 131.
MLA	binay cigdem,PAKETÇI CEM,GÜZEL Savaş,SAMANCI NEDİM Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. Journal of Clinical Research in Pediatric Endocrinology, vol.9, no.2, 2017, ss.124 - 131.
AMA	binay c,PAKETÇI C,GÜZEL S,SAMANCI N Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(2): 124 - 131.
Vancouver	binay c,PAKETÇI C,GÜZEL S,SAMANCI N Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(2): 124 - 131.
IEEE	binay c,PAKETÇI C,GÜZEL S,SAMANCI N "Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children." Journal of Clinical Research in Pediatric Endocrinology, 9, ss.124 - 131, 2017.
ISNAD	binay, cigdem vd. "Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children". Journal of Clinical Research in Pediatric Endocrinology 9/2 (2017), 124-131.