Role of free radicals in peptic ulcer and gastritis

Yılmaz, Mustafa; AYDIN, AHMET; köseoğlu, mehmet; ASLAN, Diler; AKALIN, NALAN; DEMİR, Süleyman

Role of free radicals in peptic ulcer and gastritis

Süleyman DEMİR, (Pamukkale Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Denizli, Türkiye)

Mustafa YILMAZ, (Girilmedi)

Mehmet KÖSEOĞLU, (Girilmedi)

Nalan AKALIN, (Girilmedi)

Diler ASLAN, (Girilmedi)

Ahmet AYDIN (Girilmedi)

Turkish Journal of Gastroenterology

7 0

Yıl: 2003 Cilt: 14 Sayı: 1 Sayfa Aralığı: 39 - 43 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Role of free radicals in peptic ulcer and gastritis

Öz:

Amaç: Serbest oksijen radikallerinin peptik ülser ve gastrit patogenezi ile yakından ilişkili olabileceği düşünülmektedir. Serbest oksijen radikallerinin bu patolojiler deki rolünü açıklayabilmek için çok sayıda çalışma vardır fakat bunların büyük çoğunluğu hayvan modellerinde yapılmıştır. Bu çalışma H.pylori ile infekte mide mukozasında serbest oksijen radikallerinin aktivitesi ve muhozal hasarın değerlendirilmesi amacıyla yapılmıştır. Yöntem: Çalışma 15'i peptik ülser (duo-denal), 14'i gastrit ve 12'si sağlıklı kontrol grubunda yapıldı. Peptik ülser ve gastritti hastalarda, mide mulozasında, oksidatif hasarın etkisini belirlemek için lipid peroksidasyonunun son ürünü olan malondialdehyde düzeyini araştırdık. Ayrıca reaktif oksijen radikallerinin antioksidan peptit düzeyini etkileyip etkilemediğini ortaya koymak için de mukozal kaynaklı glutathione konsantrasyonunu ölçtük, malondialdehyde ve glutathione düzeyleri mide antrumundan alınan biopsi örneklerinde ölçüldü. Bulgular: Kontrol grubu ile karşılaştırıldığında peptik ülserli hastalarda glutathione doku düzeyi belirgin olarak düşük (p<0.001), MDA düzeyinin ise yüksek olduğu (p<0.001) saptandı. Gastritli hastalarda da, 'GSR düşük (p<0.001), malondialdehyde (MDA) yüksek bulundu (p<0.01). Sonuç: H pylori pozitif peptik ülser ve gastritli hastalardaki gastrik mukozal glutathione (GSH) düzeyinde azalma lipid peroksidasyonu yoluyla memran hasarını başlatabilen serbest oksijen radikallerinin artmasının bir sonucu olabilir.

Anahtar Kelime: Peptik ülser Glutatyon Helicobacter pylori Reaktif oksijen türleri Gastrit Lipid peroksidasyonu

Konular: Cerrahi

Serbest radikallerinin peptik ülser ve gastritteki rolü

Öz:

Background/aims: It has been suggested that the free radicals are closely related with peptic ulcer disease and gastritis. Although many studies have been undertaken to clarify the role of oxygen-derived free radicals, most of them were carried out in animal models. The aim of this study was to assess the reactive oxygen species activity and the damage in Helicobacter pylori-infected gastric mucosa in humans. Methods: In a total group of 42, there were fifteen cases of peptic ulcer, 14 cases of gastritis and 12 control subjects. Measurement of gastric mucosal malondialdehyde concentrations, which is the end product of lipid peroxidation, was used to assess oxidative damage to membranes in patients with peptic ulcer and gastritis. Mucosal reduced glutathione glutathione concentrations were also measured in order to study whether reactive oxygen species generation affects levels of the antioxidant peptide. malondialdehyde and glutathione content was then measured in biopsies taken from the gastric antrum. Results: Tissue levels of glutathione were significantly (p <0.001) and malondialdehyde was higher (p<0.001) in patients with peptic ulcer compared to controls. In patients with gastritis, glutathione was also lower (p<0.001) and malondialdehyde higher (p<0.01). Conclusions: Depletion of gastric mucosal glutathione in cases with H.pylori positive peptic ulcer and gastritis may be caused by accumulation of free radicals that can initiate membrane damage by lipid peroxidation.

Anahtar Kelime: Helicobacter pylori Reactive Oxygen Species Gastritis Lipid Peroxidation Peptic Ulcer Glutathione

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMİR S, Yılmaz M, köseoğlu m, AKALIN N, ASLAN D, AYDIN A (2003). Role of free radicals in peptic ulcer and gastritis. , 39 - 43.
Chicago	DEMİR Süleyman,Yılmaz Mustafa,köseoğlu mehmet,AKALIN NALAN,ASLAN Diler,AYDIN AHMET Role of free radicals in peptic ulcer and gastritis. (2003): 39 - 43.
MLA	DEMİR Süleyman,Yılmaz Mustafa,köseoğlu mehmet,AKALIN NALAN,ASLAN Diler,AYDIN AHMET Role of free radicals in peptic ulcer and gastritis. , 2003, ss.39 - 43.
AMA	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A Role of free radicals in peptic ulcer and gastritis. . 2003; 39 - 43.
Vancouver	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A Role of free radicals in peptic ulcer and gastritis. . 2003; 39 - 43.
IEEE	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A "Role of free radicals in peptic ulcer and gastritis." , ss.39 - 43, 2003.
ISNAD	DEMİR, Süleyman vd. "Role of free radicals in peptic ulcer and gastritis". (2003), 39-43.

APA	DEMİR S, Yılmaz M, köseoğlu m, AKALIN N, ASLAN D, AYDIN A (2003). Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology, 14(1), 39 - 43.
Chicago	DEMİR Süleyman,Yılmaz Mustafa,köseoğlu mehmet,AKALIN NALAN,ASLAN Diler,AYDIN AHMET Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology 14, no.1 (2003): 39 - 43.
MLA	DEMİR Süleyman,Yılmaz Mustafa,köseoğlu mehmet,AKALIN NALAN,ASLAN Diler,AYDIN AHMET Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology, vol.14, no.1, 2003, ss.39 - 43.
AMA	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology. 2003; 14(1): 39 - 43.
Vancouver	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A Role of free radicals in peptic ulcer and gastritis. Turkish Journal of Gastroenterology. 2003; 14(1): 39 - 43.
IEEE	DEMİR S,Yılmaz M,köseoğlu m,AKALIN N,ASLAN D,AYDIN A "Role of free radicals in peptic ulcer and gastritis." Turkish Journal of Gastroenterology, 14, ss.39 - 43, 2003.
ISNAD	DEMİR, Süleyman vd. "Role of free radicals in peptic ulcer and gastritis". Turkish Journal of Gastroenterology 14/1 (2003), 39-43.