Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey

KAYASELÇUK, Fazilet; BOYACIOĞLU, Sedat; SAYGILI, Özlem B.; SERİN, ENDER; GÜMÜRDÜLÜ, Yüksel; YILMAZ, UĞUR; ÖZER, Birol

Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey

Birol ÖZER, (Başkent Üniversitesi, Adana Araştırma ve Uygulama Merkezi, Gastroenteroloji Anabilim Dalı, Adana, Türkiye)

Ender SERİN, (Girilmedi)

Uğur YILMAZ, (Girilmedi)

Yüksel GÜMÜRDÜLÜ, (Girilmedi)

Özlem B. SAYGILI, (Girilmedi)

Fazilet KAYASELÇUK, (Girilmedi)

Sedat BOYACIOĞLU (Girilmedi)

Turkish Journal of Gastroenterology

2 0

Yıl: 2003 Cilt: 14 Sayı: 2 Sayfa Aralığı: 85 - 90 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey

Öz:

Amaç: Bu çalışmanın amacı Güney Türkiye'de büyük bir sağlık merkezindeki hepatosellüler karsinomu karekteristiklerini belirlemekti. Hepatosellüler karsinom tanısında, ultrasonografi ve serum alfa fetoprotein kombinasyonu ile bilgisayarlı tomografinin etkinliği karşılaştırıldı. Yöntem: 1999-2002 yılları arasında karaciğer sirozu nedeniyle takip edilen 226 hastanın 35'ine ilk başvuru veya takipler sırasında hepatosellüler karsinom tanısı kondu. Hepatosellüler karsinom tanısı anındaki yaş, sirozun etyolojisi, sirozun şiddeti, tümör paterni, hepatosellüler karsinom evresi, serum alfa-fetoprotein düzeyi ve dinamik bilgisayarlı tomografi bulguları araştırıldı. Sonuçlar Türkiye ve başka yerlerdeki önceki bulgularla karşılaştırıldı. Bulgular: Hepatosellüler karsinom'lı hastalarda erkek: kadın oranı 4:1 ve tanı anındaki ortalama yaş 61 idi. Kronik hepatit B virüs hepatosellüler karsinom infiksiyonu (%65.7) ve kronik hepatit C virüs hepatosüller karsinoma infeksiyonu (%28.6), hepatosellüler karsinom için en sık saptanan risk faktörüydü. Hepatosellüler karsinom tanısı konduğu anda hastaların %40'ı Child-Pugh A evresinde idi. Vakaların %67'sinde hepatosellüler karsinom tanısı anında karaciğerde 3'den az hepatosellüler karsinom nodulu vardı, hepatosellüler karsinom vakalarının yalnızca 3 tanesi Okuda evre l idi. 35 hastanın 32'sinde hepatosellüler karsinom tanısı serum AFP>200 ng/ml ve ultrasonografi kombinasyonu ile konuldu. Sonuç: Bu sonuçlar sirozlu hastalarda hepatosellüler karsinom infeksiyonun hepatosellüler karsinom gelişiminde halen önde gelen risk faktörü olduğunu göstermiştir. Türkiye'nin bu bölgesindeki sirozlu hastalarda erken evrede hepatosellüler karsinom nadiren saptanmıştır. Hepatosellüler karsinom'nın erken tanısında bilgisayarlı tomografi ile takip zorunlu gibi görünmemektedir.

Anahtar Kelime: Tomografi, x-ışınlı bilgisayarlı Karsinom, hepatosellüler Türkiye Ultrasonografi alfa-Fetoproteinler

Konular: Cerrahi

Hepatosellüler karsinomun klinikopatolojik özellikleri ve risk faktörleri: Türkiye'nin güney bölümünde tek merkez sonuçları

Öz:

Background/aims: The aim of this study was to determine the characteristics of hepatocellular carcinoma at a major health center in Southern Turkey. Computed tomography was compared to the combination of ultrasonography and serum alpha-fetoprotein determination in the diagnosis of hepatocellular carcinoma. Methods: Of 226 patients with liver cirrhosis, 35 were diagnosed with hepatocellular carcinoma on first admission or during follow-up in the period between 1999 and 2002. The features investigated were, age at time of hepatocellular carcinoma diagnosis, etiology of cirrhosis, severity of cirrhosis at pre-sentation, tumor pattern, stage of hepatocellular carcinoma, se-rum alpha-fetoprotein level, and dynamic computed tomography findings. Results were compared to previous findings in Turkey and elsewhere. Results: In the hepatocellular carcinoma patients, the male:female ratio was 4:1 and the mean age at presentation was 61 years. Chronic hepatitis B virus infection (65.7%) and chronic hepatitis C virus infection (28.6%) were the most frequently identified risk factors for hepatocellular carcinoma. Forty percent of the patients had Child-Pugh A cirrhosis when they were diagnosed with hepatocellular carcinoma. Sixty-seven percent of patients had fewer than three hepatocellular carcinoma nodules in the liver at the time of diagnosis. Only three of the hepatocellular carcinoma cases were Okuda stage I. The combination of ultrasonography and serum alpha-fetoprotein >20 ng/ml identified hepatocellular carcinoma in 32 of the 35 total cases. Conclusions: The results indicate that hepatitis B virus infection in patients with cirrhosis is still the leading risk factor for the development of hepatocellular carcinoma. Also, early-stage hepatocellular carcinoma is rarely diagnosed in cirrhosis patients from this region of Turkey. Surveillance with computed tomography for early diagnosis of hepatocellular carcinoma seems not to be mandatory.

Anahtar Kelime: Turkey Ultrasonography alpha-Fetoproteins Tomography, X-Ray Computed Carcinoma, Hepatocellular

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZER B, SERİN E, YILMAZ U, GÜMÜRDÜLÜ Y, SAYGILI Ö, KAYASELÇUK F, BOYACIOĞLU S (2003). Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. , 85 - 90.
Chicago	ÖZER Birol,SERİN ENDER,YILMAZ UĞUR,GÜMÜRDÜLÜ Yüksel,SAYGILI Özlem B.,KAYASELÇUK Fazilet,BOYACIOĞLU Sedat Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. (2003): 85 - 90.
MLA	ÖZER Birol,SERİN ENDER,YILMAZ UĞUR,GÜMÜRDÜLÜ Yüksel,SAYGILI Özlem B.,KAYASELÇUK Fazilet,BOYACIOĞLU Sedat Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. , 2003, ss.85 - 90.
AMA	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. . 2003; 85 - 90.
Vancouver	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. . 2003; 85 - 90.
IEEE	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S "Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey." , ss.85 - 90, 2003.
ISNAD	ÖZER, Birol vd. "Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey". (2003), 85-90.

APA	ÖZER B, SERİN E, YILMAZ U, GÜMÜRDÜLÜ Y, SAYGILI Ö, KAYASELÇUK F, BOYACIOĞLU S (2003). Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. Turkish Journal of Gastroenterology, 14(2), 85 - 90.
Chicago	ÖZER Birol,SERİN ENDER,YILMAZ UĞUR,GÜMÜRDÜLÜ Yüksel,SAYGILI Özlem B.,KAYASELÇUK Fazilet,BOYACIOĞLU Sedat Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. Turkish Journal of Gastroenterology 14, no.2 (2003): 85 - 90.
MLA	ÖZER Birol,SERİN ENDER,YILMAZ UĞUR,GÜMÜRDÜLÜ Yüksel,SAYGILI Özlem B.,KAYASELÇUK Fazilet,BOYACIOĞLU Sedat Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. Turkish Journal of Gastroenterology, vol.14, no.2, 2003, ss.85 - 90.
AMA	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. Turkish Journal of Gastroenterology. 2003; 14(2): 85 - 90.
Vancouver	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey. Turkish Journal of Gastroenterology. 2003; 14(2): 85 - 90.
IEEE	ÖZER B,SERİN E,YILMAZ U,GÜMÜRDÜLÜ Y,SAYGILI Ö,KAYASELÇUK F,BOYACIOĞLU S "Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey." Turkish Journal of Gastroenterology, 14, ss.85 - 90, 2003.
ISNAD	ÖZER, Birol vd. "Clinicopathologic features and risk factors for hepatocellular carcinoma: Results from a single center in Southern Turkey". Turkish Journal of Gastroenterology 14/2 (2003), 85-90.