Objective: Allergic reactions that occurring as a resultof drug allergy can result in anaphylaxis, evendeath. These reactions often evaluated by the primarycare physicians. Primary care physicians who oftenencounter with drug allergy reactions should be ableto evaluate the patients with drug allergy, if necessary,make first emergency intervention, and refer patientsto an allergy specialist for further evaluation and treatment.In this study, we aimed to measure general approachand the level of knowledge family physiciansabout allergic reactions occurred after the drug allergy.Materials and Methods: Two hundred and fivefamily physicians who work in the region of Malatyaand Samsun participated in this study. We interviewedface-to-face with family physicians about drug allergy.After that, family physicians completed a questionnairepreviously prepared by allergy specialists aboutdrug allergy.Results: The median age was 38 years old (min: 24,max: 61), median length of professional experiencewas 13 (min: 1, max: 35) years old and 124 (60.5%) ofparticipants were male gender. 90.2% of family physicians in this study expressed to encounter with drugallergy before. 52.2% of them explained to cut medicationin case of allergic reaction that developed afterdrug intake and to refer patients to allergy specialist forfurther investigation. 39.5% of the participants didn'tknow that a systemic reaction will be able to occur afterlocal drug using. 56.6% of family physicians statedthat they needn't to cut responsible medication inmild drug reactions and only 35.1% of them knew thatsevere drug reactions can be fatal. Only 31.7% of participantsexplained that adrenaline is the first optionwhen anaphylactic reaction occurs after drug allergy.Conclusion: The knowledge of primary care physiciansabout treatment and management of patientswith drug allergy is insufficient. Therefore, it will beuseful to be educated the primary care physiciansabout drug allergies.