Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Koc Demir, Aysel

Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Aysel KOÇ DEMİR (Ankara University, Department of Biochemistry, Ankara, TURKEY)

Hittite Journal of Science and Engineering

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Yıl: 2017 Cilt: 4 Sayı: 1 Sayfa Aralığı: 45 - 49 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Öz:

In this study, a scaffold composed of chitosan (C) and organoclay (OC) was prepared by utilizing freeze-drying method. The composition of resulting composite scaffold was evaluated using FTIR and SEM. The in vivo cytocompatibility of the composite was evaluated in vivo, by seeding MC3T3-E1 cells on composite scaffolds. In-vitro cell viability and proliferation were investigated using the MTT assay, while cell-scaffold constructs were evaluated using scanning electron microscopy. Preliminary in vivo experiments were also performed to evaluate tissue compatibility and ectopic boneforming potential of C/OC composite scaffolds with MC3T3-E1 cells. The findings suggest that C/OC construct supported the proliferation of MC3T3-E1 cells, presented histobiocompatibility and promoted formation of calcified matrix. Based on the results, we conclude that the characterized C/OC composite system may have potential for use in bone tissue engineering applications.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Koc Demir A (2017). Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. , 45 - 49.
Chicago	Koc Demir Aysel Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. (2017): 45 - 49.
MLA	Koc Demir Aysel Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. , 2017, ss.45 - 49.
AMA	Koc Demir A Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. . 2017; 45 - 49.
Vancouver	Koc Demir A Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. . 2017; 45 - 49.
IEEE	Koc Demir A "Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold." , ss.45 - 49, 2017.
ISNAD	Koc Demir, Aysel. "Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold". (2017), 45-49.

APA	Koc Demir A (2017). Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering, 4(1), 45 - 49.
Chicago	Koc Demir Aysel Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering 4, no.1 (2017): 45 - 49.
MLA	Koc Demir Aysel Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering, vol.4, no.1, 2017, ss.45 - 49.
AMA	Koc Demir A Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering. 2017; 4(1): 45 - 49.
Vancouver	Koc Demir A Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold. Hittite Journal of Science and Engineering. 2017; 4(1): 45 - 49.
IEEE	Koc Demir A "Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold." Hittite Journal of Science and Engineering, 4, ss.45 - 49, 2017.
ISNAD	Koc Demir, Aysel. "Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold". Hittite Journal of Science and Engineering 4/1 (2017), 45-49.