TY  - JOUR
TI  - A case of hyperkinetic movement disorder associated with LGI1 antibodies
AB  - Erer-Özbek S, Yapıcı Z, Tüzün E, Giriş M, Duran S, Taşkapılıoğlu Ö, Okan M. A case of hyperkinetic movement disorder associated with LGI1 antibodies. Turk J Pediatr 2015; 57: 514-517.Encephalitis associated with leucine-rich glioma inactivated 1 (LGI1) antibodies is often encountered in elderly male patients and may infrequently present with isolated syndromes. A 6-year-old boy was admitted with acute onset severe oral and facial stereotypic and choreiform movements. On his neurologic examination, he had repetitive and rhythmic movements in orolingual muscles including tongue protrusion, limb chorea and minimal facial stereotypic movements. Anti-streptolysin O (ASO) titers were found severely elevated in several measurements. Well-characterized antibodies against ion channels and synapse proteins were negative whereas LGI1 antibody was positive in both serum and CSF. Marked clinical improvement was observed after immunotherapy. Here, we present the first pediatric case with LGI1 antibody associated hyperkinetic movement disorders and emphasize the importance of investigating neuronal autoantibodies in patients with isolated and treatment resistant movement disorders
AU  - YAPICI, Zuhal
AU  - OKAN, Mehmet
AU  - DURAN, Selcen
AU  - Taşkapılıoğlu, Özlem
AU  - Tuzun, Erdem
AU  - GİRİŞ, Murat
AU  - ERER ÖZBEK, Çiğdem Sevda
PY  - 2015
JO  - Turkish Journal of Pediatrics
VL  - 57
IS  - 5
SN  - 0041-4301
SP  - 514
EP  - 517
DB  - TRDizin
UR  - http://search/yayin/detay/231324
ER  -