TY  - JOUR
TI  - Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?
AB  - Objective: Obesity causes subclinical inflammation. Leukocyte count and high-sensitivity C-reactive protein (hs-CRP) are used to indicateinflammation in clinical practice. Also, inflammatory markers are evaluated as important indicators of cardiovascular risk in patients with obesity and metabolic syndrome (MetS). We aimed to investigate the usage of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker inobese patients with and without MetS.Methods: The study included a total of 1267 patients. The patients were assigned groups according to degree of obesity and status of MetS.Metabolic and inflammatory markers were compared between groups, and correlation analysis was performed.Results: Leukocyte count and hs-CRP were significantly different (p<0.001), but NLR was not different between body mass index (BMI) groups(p=0.168). Both lymphocyte and neutrophil counts were significantly increased with increased degree of obesity (p<0.001, p=0.028, respectively). Leukocyte, neutrophil, and lymphocyte counts and hs-CRP level showed a significant correlation with BMI (r=0.198, p<0.001; r=0.163,p<0.001; r=0.167, p<0.001; r=0.445, p<0.001, respectively), whereas NLR was not correlated with BMI (r=0.017, p=0.737). Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant associationfor leukocyte count and NLR (p=0.246; p=0.643, respectively).Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammationin non-diabetic patients with obesity and MetS. (Anatol J Cardiol 2015; 15: 816-22)Keywords: metabolic syndrome, neutrophil-lymphocyte ratio, obesity, inflammation
AU  - Bahadır, anzel
AU  - ILİEV, Darkov
AU  - TÜRKER, Yasemin
AU  - BALTACI, Davut
AU  - DELER, Mehmet Harun
AU  - SARIGÜZEL, Yunus Cem
AU  - Öztürk, Serkan
AU  - TÜRKER, Yasin
PY  - 2015
JO  - The Anatolian Journal of Cardiology
VL  - 15
IS  - 10
SN  - 2149-2263
SP  - 816
EP  - 822
DB  - TRDizin
UR  - http://search/yayin/detay/232430
ER  -