Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

KIRBAŞ, Özgür; KUYUMCU, MEVLÜT SERDAR; GÖKASLAN, SERKAN; YAYLA, Kadriye Gayretli; Köseoğlu, Cemal; AYDOĞDU, Sinan; Efe, Tolga Han; Acar, Burak; ÜNAL, Sefa; Akboga, Mehmet Kadri; GÖKTUĞ ERTEM, Ahmet; YAYLA, ÇAĞRI

Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

The Anatolian Journal of Cardiology

2 1

Yıl: 2017 Cilt: 17 Sayı: 2 Sayfa Aralığı: 119 - 124 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

Öz:

Objective: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.Methods: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.Results: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998–1.000; p=0.007).Conclusion: Adropin could be an alternative blood sample value for predicting severity of CAD

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Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005; 1: 219-27.
2. Yang CH, Hsieh MJ, Chen CC, Chang SH, Wang CY, Lee CH, et al. SYNTAX score: an independent predictor of long-term cardiac mortality in patients with acute ST-elevation myocardial infarction. Coron Artery Dis 2012; 23: 445-9.
3. Chakrabarti AK, Gibson CM. The SYNTAX score: usefulness, limitations, and future directions. J Invasive Cardiol 2011; 23: 511-2.
4. Kundi H, Gök M, Çetin M, Kızıltunç E, Topçuoğlu C, Neşelioğlu S, et al. Association of thiol disulfide homeostasis with slow coronary flow. Scand Cardiovasc J 2016: 50: 213-7.
5. Zhao LP, Xu WT, Wang L, You T, Chan SP, Zhao X, et al. Serum adropin level in patients with stable coronary artery disease. Heart Lung Circ 2015; 24: 975-9.
6. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab 2008; 8: 468-81.
7. Li L, Xie W, Zheng XL, Yin WD, Tang CK. A novel peptide adropin in cardiovascular diseases. Clin Chim Acta 2016; 453: 107-13.
8. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation 2010; 122(11 Suppl): S185-92.
9. Yu HY, Zhao P, Wu MC, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regul Pept 2014; 191: 46-9.
10. Demirçelik B, Çakmak M, Nazlı Y, Gürel OM, Akkaya N, Çetin M, et al. Adropin: a new marker for predicting late saphenous vein graft disease after coronary artery bypass grafting. Clin Invest Med 2014; 37: E338-44.
11. Mandelzweig L, Battler A, Boyko V, Bueno H, Danchin N, Filippatos G, et al. The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur Heart J 2006; 27: 2285-93.
12. Terkelsen CJ, Lassen JF, Norgaard BL, Gerdes JC, Jensen T, Gotzsche LB, et al. Mortality rates in patients with ST-elevation vs. non-ST-elevation acute myocardial infarction: observations from an unselected cohort. Eur Heart J 2005; 26: 18-26.
13. Savonitto S, Ardissino D, Granger CB, Morando G, Prando MD, Mafrici A, et al. Prognostic value of the admission electrocardiogram in acute coronary syndromes. JAMA 1999; 281: 707-13.
14. Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 2009; 360: 961-72.
15. Farooq V, Serruys PW, Bourantas C, Vranckx P, Diletti R, Garcia Garcia HM, et al. Incidence and multivariable correlates of long-term mortality in patients treated with surgical or percutaneous revascularization in the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) trial. Eur Heart J 2012; 33: 3105-13.
16. Garg S, Serruys PW, Silber S, Wykrzykowska J, van Geuns RJ, Richardt G, et al. The prognostic utility of the SYNTAX score on 1-year outcomes after revascularization with zotarolimus- and everolimuseluting stents: a substudy of the RESOLUTE All Comers Trial. JACC Cardiovasc Interv 2011; 4: 432-41.
17. Ramamurthy CH, Kumar MS, Suyavaran VS, Mareeswaran R, Thirunavukkarasu C. Evaluation of antioxidant, radical scavenging activity and polyphenolics profile in Solanum torvum L. fruits. J Food Sci 2012; 77: C907-13.
18. Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol 2002; 53: 503-14.
19. Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Molero-Ramirez H, Tan HL, Bandla HP. Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function. J Pediatr 2013; 163: 1122-6.
20. Topuz M, Çelik A, Aslantaş T, Demir AK, Aydın S, Aydın S. Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus. J Investig Med 2013; 61: 1161-4.
21. Çelik A, Balin M, Kobat MA, Erdem K, Baydas A, Bulut M, et al. Deficiency of a new protein associated with cardiac syndrome X; called adropin. Cardiovasc Ther 2013; 31: 174-8.
22. Chilton RJ. Recent discoveries in assessment of coronary heart disease: impact of vascular mechanisms on development of atherosclerosis. J Am Osteopath Assoc 2001; 101(9 Suppl): S1-5.
23. Raposeiras Roubin S, Barreiro Pardal C, Roubin-Camina F, Ocaranza Sanchez R, Alvarez Castro E, Paradela Dobarro B, et al. Highsensitivity C-reactive protein predicts adverse outcomes after non-ST-segment elevation acute coronary syndrome regardless of GRACE risk score, but not after ST-segment elevation myocardial infarction. Rev Port Cardiol 2013; 32: 117-22.
24. Wu L, Fang J, Chen L, Zhao Z, Luo Y, Lin C, et al. Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients. Clin Chem Lab Med 2014; 52: 751-8.
25. Zhao LP, You T, Chan SP, Chen JC, Xu WT. Adropin is associated with hyperhomocysteine and coronary atherosclerosis. Exp Ther Med 2016; 11: 1065-70.
26. Aydın HI, Eser A, Kaygusuz I, Yıldırım S, Çelik T, Gündüz S, et al. Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers. J Perinat Med 2016; 44: 669- 76.
27. Lian W, Gu X, Qin Y, Zheng X. Elevated plasma levels of adropin in heart failure patients. Intern Med 2011; 50: 1523-7.

APA	GÖKTUĞ ERTEM A, ÜNAL S, Efe T, Acar B, YAYLA Ç, KUYUMCU M, KIRBAŞ Ö, Köseoğlu C, Akboga M, YAYLA K, GÖKASLAN S, AYDOĞDU S (2017). Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. , 119 - 124.
Chicago	GÖKTUĞ ERTEM Ahmet,ÜNAL Sefa,Efe Tolga Han,Acar Burak,YAYLA ÇAĞRI,KUYUMCU MEVLÜT SERDAR,KIRBAŞ Özgür,Köseoğlu Cemal,Akboga Mehmet Kadri,YAYLA Kadriye Gayretli,GÖKASLAN SERKAN,AYDOĞDU Sinan Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. (2017): 119 - 124.
MLA	GÖKTUĞ ERTEM Ahmet,ÜNAL Sefa,Efe Tolga Han,Acar Burak,YAYLA ÇAĞRI,KUYUMCU MEVLÜT SERDAR,KIRBAŞ Özgür,Köseoğlu Cemal,Akboga Mehmet Kadri,YAYLA Kadriye Gayretli,GÖKASLAN SERKAN,AYDOĞDU Sinan Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. , 2017, ss.119 - 124.
AMA	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. . 2017; 119 - 124.
Vancouver	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. . 2017; 119 - 124.
IEEE	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S "Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction." , ss.119 - 124, 2017.
ISNAD	GÖKTUĞ ERTEM, Ahmet vd. "Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction". (2017), 119-124.

APA	GÖKTUĞ ERTEM A, ÜNAL S, Efe T, Acar B, YAYLA Ç, KUYUMCU M, KIRBAŞ Ö, Köseoğlu C, Akboga M, YAYLA K, GÖKASLAN S, AYDOĞDU S (2017). Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. The Anatolian Journal of Cardiology, 17(2), 119 - 124.
Chicago	GÖKTUĞ ERTEM Ahmet,ÜNAL Sefa,Efe Tolga Han,Acar Burak,YAYLA ÇAĞRI,KUYUMCU MEVLÜT SERDAR,KIRBAŞ Özgür,Köseoğlu Cemal,Akboga Mehmet Kadri,YAYLA Kadriye Gayretli,GÖKASLAN SERKAN,AYDOĞDU Sinan Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. The Anatolian Journal of Cardiology 17, no.2 (2017): 119 - 124.
MLA	GÖKTUĞ ERTEM Ahmet,ÜNAL Sefa,Efe Tolga Han,Acar Burak,YAYLA ÇAĞRI,KUYUMCU MEVLÜT SERDAR,KIRBAŞ Özgür,Köseoğlu Cemal,Akboga Mehmet Kadri,YAYLA Kadriye Gayretli,GÖKASLAN SERKAN,AYDOĞDU Sinan Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. The Anatolian Journal of Cardiology, vol.17, no.2, 2017, ss.119 - 124.
AMA	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. The Anatolian Journal of Cardiology. 2017; 17(2): 119 - 124.
Vancouver	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction. The Anatolian Journal of Cardiology. 2017; 17(2): 119 - 124.
IEEE	GÖKTUĞ ERTEM A,ÜNAL S,Efe T,Acar B,YAYLA Ç,KUYUMCU M,KIRBAŞ Ö,Köseoğlu C,Akboga M,YAYLA K,GÖKASLAN S,AYDOĞDU S "Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction." The Anatolian Journal of Cardiology, 17, ss.119 - 124, 2017.
ISNAD	GÖKTUĞ ERTEM, Ahmet vd. "Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction". The Anatolian Journal of Cardiology 17/2 (2017), 119-124.