Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu

TEMEL, Yasin; KOCABICAK, Ersoy; TAN, Sonny; JAHANSHAHI, Ali; HESCHAM, Sarah-Anna; SCHONFELD, Lisa

Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu

Ersoy KOCABICAK, (Ondokuz Mayıs University)

Ali JAHANSHAHI, (Maastricht University Medical Center, Departments of Neuroscience and Neurosurgery, Maastricht, Netherlands)

Lisa SCHONFELD, (Maastricht University Medical Center, Departments of Neuroscience and Neurosurgery, Maastricht, Netherlands)

Sarah-Anna HESCHAM, (Maastricht University Medical Center, Departments of Neuroscience and Neurosurgery, Maastricht, Netherlands)

Yasin TEMEL, (Maastricht University Medical Center, Departments of Neuroscience and Neurosurgery, Maastricht, Netherlands)

Sonny TAN (University Hospital RWTH Aachen, Department of Neurosurgery, Aachen, Germany)

Turkish Neurosurgery

28 0

Yıl: 2015 Cilt: 25 Sayı: 5 Sayfa Aralığı: 721 - 727 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu

Öz:

AmAÇ: İleri evre Parkinson hastalığında uygulanan subtalamik nükleus (STN) derin beyin stimülasyonu (DBS) tremor, bradikinezi ve rijidite gibi motor semptomların gerilemesini sağlar. Bununla beraber, STN DBS ile tedavi edilmiş hastalarda depresyon, duygu durum bozukluğu gibi istenmeyen bazı psikiyatrik yan etkiler oluşabilir. Bu psikiyatrik yan etkilerin nöral temelinde 5-hydroxytryptamine (5-HT, serotonin) iletimindeki değişikliklerin rol oynadığı düşünülmektedir. Dopaminerjik nöron kaynağı olarak da görev yapan median raphe nükleusu (MRN) , tıpkı dorsal raphe nükleusu gibi ratlarda bir diğer serotonerjik nöron kaynağıdır. STN DBS'in rat dorsal raphe nükleusunda serotonerjik aktivite gösteren hücreleri inhibe ettiği daha önce gösterilmiştir. Fakat STN DBS'in MRN üzerinde ne gibi etki gösterdiği bilinmemektedir. Çalışmamızda STN DBS'in sıçan median raphe nükleusunda serotonin ve dopaminerjik fonksiyonları azalttığına dair hipotezimizi araştırdık.yÖntem ve GereÇler: Bilateral STN DBS serbest hareket eden sıçan modeline uygulandı. STN DBS sonrası sıçanlar sakrifiye edildi ve beyinleri c-Fos, 5-HT ve tirozin hidroksilaz (TH) ile immünohistokimyasal olarak işlendi. BulGulAr: STN DBS'in, stimüle edilmemiş kontrol grubuyla karşılaştırıldığında c-Fos ekspresyonunu önemli oranda azalttığını tespit ettik. Ayrıca MRN içindeki 5-HT ve TH hücrelerinin ortalama optik dansite değerleri, kontrol grubuyla karşılaştırıldığında oldukça düşüktü. sOnuÇ: Bu sonuçlar, STN DBS'in median raphe nükleusunda 5-HT ve dopamin salınımını inhibe ettiğini göstermektedir.

Anahtar Kelime:

Konular: Cerrahi

Deep Brain Stimulation of the Rat Subthalamic nucleus Induced Inhibition of Median Raphe Serotonergic and Dopaminergic neurotransmission

Öz:

AIm: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) relieves motor dysfunction in advanced Parkinson's disease (PD). However, STN DBS treated patients can experience unpleasant and debilitating psychiatric side effects such as depression and impulsivity. The neural basis of these psychiatric effects has been linked to a dysfunction of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission. STN DBS inhibited activity of 5-HT cell bodies in the dorsal raphe nucleus (DRN). Another important 5-HT source is located in the median raphe nucleus (MRN), which also contains a population of dopamine neurons. The effects of STN DBS on the MRN are unknown. Here, we test the hypothesis that STN DBS reduces 5-HT and dopaminergic function in the MRN, which may contribute to the psychiatric side effects of STN stimulation. mAterIAl and methOds: Bilateral STN DBS was applied in a freely moving rat model. Following STN DBS, rats were sacrificed and the brains were processed for c-Fos, 5-HT and tyrosine hydroxylase (TH) immunohistochemistry. results: We found that STN DBS significantly lowered c-Fos expression compared to non-stimulated controls indicating reduced neuronal activity. Moreover, the mean optical density values of 5-HT and TH cells in the MRN was significantly lower compared to controls. COnClusIOn: These results show that STN DBS inhibits 5-HT and dopamine neurotransmission in the MRN.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KOCABICAK E, JAHANSHAHI A, SCHONFELD L, HESCHAM S, TEMEL Y, TAN S (2015). Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. , 721 - 727.
Chicago	KOCABICAK Ersoy,JAHANSHAHI Ali,SCHONFELD Lisa,HESCHAM Sarah-Anna,TEMEL Yasin,TAN Sonny Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. (2015): 721 - 727.
MLA	KOCABICAK Ersoy,JAHANSHAHI Ali,SCHONFELD Lisa,HESCHAM Sarah-Anna,TEMEL Yasin,TAN Sonny Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. , 2015, ss.721 - 727.
AMA	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. . 2015; 721 - 727.
Vancouver	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. . 2015; 721 - 727.
IEEE	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S "Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu." , ss.721 - 727, 2015.
ISNAD	KOCABICAK, Ersoy vd. "Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu". (2015), 721-727.

APA	KOCABICAK E, JAHANSHAHI A, SCHONFELD L, HESCHAM S, TEMEL Y, TAN S (2015). Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. Turkish Neurosurgery, 25(5), 721 - 727.
Chicago	KOCABICAK Ersoy,JAHANSHAHI Ali,SCHONFELD Lisa,HESCHAM Sarah-Anna,TEMEL Yasin,TAN Sonny Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. Turkish Neurosurgery 25, no.5 (2015): 721 - 727.
MLA	KOCABICAK Ersoy,JAHANSHAHI Ali,SCHONFELD Lisa,HESCHAM Sarah-Anna,TEMEL Yasin,TAN Sonny Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. Turkish Neurosurgery, vol.25, no.5, 2015, ss.721 - 727.
AMA	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. Turkish Neurosurgery. 2015; 25(5): 721 - 727.
Vancouver	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu. Turkish Neurosurgery. 2015; 25(5): 721 - 727.
IEEE	KOCABICAK E,JAHANSHAHI A,SCHONFELD L,HESCHAM S,TEMEL Y,TAN S "Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu." Turkish Neurosurgery, 25, ss.721 - 727, 2015.
ISNAD	KOCABICAK, Ersoy vd. "Subtalamik Nükleus Derin Beyin Stimülasyonu Sonrası Sıçan Median Raphe Nükleusunda Serotonerjik ve Dopaminerjik İletimin İnhibisyonu". Turkish Neurosurgery 25/5 (2015), 721-727.