Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

KURT, Ömer; UYGUN İLİKHAN, Sevil; KÖKTÜRK, Fürüzan; ÖZTÜRK, Kadir; üstündağ, yücel; bilici, muammer; Demirci, Hakan; Uygun, Ahmet

Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

Hakan DEMİRCİ, (Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey)

Sevil UYGUN İLİKHAN, (Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey)

Kadir ÖZTÜRK, (Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey)

Yücel ÜSTÜNDAĞ, (Department of Gastroenterology, Bülent Ecevit University, Zonguldak, Turkey)

Ömer KURT, (Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey)

Muammer BİLİCİ, (Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey)

Fürüzan KÖKTÜRK, (Department of Statistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey)

Ahmet UYGUN (Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey)

Turkish Journal of Gastroenterology

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Yıl: 2015 Cilt: 26 Sayı: 6 Sayfa Aralığı: 456 - 460 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

Öz:

Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in group D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05).Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demirci H, UYGUN İLİKHAN S, ÖZTÜRK K, üstündağ y, KURT Ö, bilici m, KÖKTÜRK F, Uygun A (2015). Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. , 456 - 460.
Chicago	Demirci Hakan,UYGUN İLİKHAN Sevil,ÖZTÜRK Kadir,üstündağ yücel,KURT Ömer,bilici muammer,KÖKTÜRK Fürüzan,Uygun Ahmet Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. (2015): 456 - 460.
MLA	Demirci Hakan,UYGUN İLİKHAN Sevil,ÖZTÜRK Kadir,üstündağ yücel,KURT Ömer,bilici muammer,KÖKTÜRK Fürüzan,Uygun Ahmet Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. , 2015, ss.456 - 460.
AMA	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. . 2015; 456 - 460.
Vancouver	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. . 2015; 456 - 460.
IEEE	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A "Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection." , ss.456 - 460, 2015.
ISNAD	Demirci, Hakan vd. "Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection". (2015), 456-460.

APA	Demirci H, UYGUN İLİKHAN S, ÖZTÜRK K, üstündağ y, KURT Ö, bilici m, KÖKTÜRK F, Uygun A (2015). Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology, 26(6), 456 - 460.
Chicago	Demirci Hakan,UYGUN İLİKHAN Sevil,ÖZTÜRK Kadir,üstündağ yücel,KURT Ömer,bilici muammer,KÖKTÜRK Fürüzan,Uygun Ahmet Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology 26, no.6 (2015): 456 - 460.
MLA	Demirci Hakan,UYGUN İLİKHAN Sevil,ÖZTÜRK Kadir,üstündağ yücel,KURT Ömer,bilici muammer,KÖKTÜRK Fürüzan,Uygun Ahmet Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology, vol.26, no.6, 2015, ss.456 - 460.
AMA	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology. 2015; 26(6): 456 - 460.
Vancouver	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology. 2015; 26(6): 456 - 460.
IEEE	Demirci H,UYGUN İLİKHAN S,ÖZTÜRK K,üstündağ y,KURT Ö,bilici m,KÖKTÜRK F,Uygun A "Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection." Turkish Journal of Gastroenterology, 26, ss.456 - 460, 2015.
ISNAD	Demirci, Hakan vd. "Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection". Turkish Journal of Gastroenterology 26/6 (2015), 456-460.