Yıl: 2016 Cilt: 16 Sayı: 12 Sayfa Aralığı: 900 - 915 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study

Öz:
Objective: To evaluate the acute phase (pre- and in-hospital) antithrombotic management patterns (AMPs) and in-hospital outcomes for patients hospitalized with an acute coronary syndrome (ACS).Methods: In total, 1034 patients [514 patients with ST-segment elevation myocardial infarction (STEMI) and 520 with unstable angina/non-STEMI (UA/NSTEMI)] hospitalized for ACS within 24 h of symptom onset were included in this multicenter prospective registry study conducted at 34 hospitals across Turkey. Patient characteristics, index event description, pre- and in-hospital AMPs, and clinical outcomes were evaluated.Results: Majority (89.1%) of patients did not receive pre-hospital treatment. Overall 87.9% patients with STEMI and 55.6% patients with NSTEMI underwent percutaneous coronary intervention and dual antiplatelet therapy (DAPT) was based mainly on acetylsalicylic acid (ASA) and clopidogrel during hospitalization (99.8% and 98.2%, respectively). DAPT use at discharge was 98.4% and 86.8%, respectively. The percentage of patients with STEMI who received pre-hospital care, in-hospital cardiac catheterization, and pre and/or in-hospital triple antiplatelet therapy was higher than that of patients with UA/NSTEMI. In addition, higher rate of in-hospital hemorrhagic (2.3% vs. 0.8%) and cardiac ischemic (1.2% vs. 0.4% for MI and 1.6% vs. 0.8% for recurrent ischemia) complications and earlier induction of pre and/or in-hospital antiplatelet therapy and cardiac catheterization were also noted in patients with STEMI than in those with UA/NSTEMI.Conclusion: Our findings revealed in-hospital and at-discharge management to be mainly based on DAPT in patients with ACS. Interventional strategies were used in the majority of patients with STEMI, while the usage and timing of immediate pre-hospital ECG from symptom onset should be improved in these patients
Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE Jr, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2012; 60: 645-81.
  • 2. Kushner FG, Hand M, Smith SC Jr, King SB 3rd, Anderson JL, Antman EM, et al. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/ AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2009; 54: 2205-41.
  • 3. Davies MJ. The pathophysiology of acute coronary syndromes. Heart 2000; 83: 361-6.
  • 4. Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, et al.; American College of Cardiology; American Heart Association. Committee on the Management of Patients With Unstable Angina. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol 2002; 40: 1366-74.
  • 5. Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008; 29: 2909-45.
  • 6. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol 2005; 46: 937-54.
  • 7. Fox KA. Coronary disease. Acute coronary syndromes: presentation-clinical spectrum and management. Heart 2000; 84: 93-100.
  • 8. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2016; 37: 267-315.
  • 9. Fox KA, Carruthers KF, Dunbar DR, Graham C, Manning JR, De Raedt H, et al. Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK–Belgian Study). Eur Heart J 2010; 31: 2755-64.
  • 10. Fox KA, Clayton TC, Damman P, Pocock SJ, de Winter RJ, Tijssen JG, et al. Long-term outcome of a routine versus selective invasive strategy in patients with non–ST-segment elevation acute coronary syndrome a meta-analysis of individual patient data. J Am Coll Cardiol 2010; 55: 2435-45.
  • 11. Harnek J, Nilsson J, Friberg O, James S, Lagerqvist B, Hambraeus K, et al. The 2011 outcome from the Swedish Health Care Registry on Heart Disease (SWEDEHEART). Scand Cardiovasc J 2013; 47: 1-10.
  • 12. Bueno H, Danchin N, Tafalla M, Bernaud C, Annemans L, Van de Werf F. EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) study: rationale, design, and baseline characteristics. Am Heart J 2013; 165: 8-14.
  • 13. Hanssen M, Cottin Y, Khalife K, Hammer L, Goldstein P, Puymirat E, et al. French registry of acute ST-elevation and non ST-elevation myocardial infarction 2010. FAST-MI 2010. Heart 2012; 98: 699-705.
  • 14. Awad HH, Zubaid M, Alsheikh-Ali AA, Al Suwaidi J, Anderson FA Jr, Gore JM, et al. Comparison of characteristics, management practices, and outcomes of patients between the global registry and the Gulf registry of acute coronary events. Am J Cardiol 2011; 108: 1252-8.
  • 15. Tokgözoğlu L, Kaya EB, Erol C, Ergene O; EUROASPIRE III Turkey Study Group. [EUROASPIRE III: a comparison between Turkey and . Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, et al.; CREATE registry investigators. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet 2008; 371: 1435-42.
  • 17. Moustaghfir A, Haddak M, Mechmeche R. Management of acute coronary syndromes in Maghreb countries: The ACCESS (ACute Coronary Events - a multinational Survey of current management Strategies) registry. Arch Cardiovasc Dis 2012; 105: 566-77.
  • 18. Steg PG, Goldberg RJ, Gore JM, Fox KA, Eagle KA, Flather MD, et al.; GRACE Investigators. Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am J Cardiol 2002; 90: 358-63.
  • 19. Hasdai D, Behar S, Wallentin L, Danchin N, Gitt AK, Boersma E, et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J 2002; 23: 1190-201.
  • 20. Mandelzweig L, Battler A, Boyko V, Bueno H, Danchin N, Filippatos G, et al.; Euro Heart Survey Investigators. The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basın in 2004. Eur Heart J 2006; 27: 2285-93.
  • 21. Gersh BJ, Stone GW, White HD, Holmes DR Jr. Pharmacological facilitation of primary percutaneous coronary intervention for acute myocardial infarction: is the slope of the curve the shape of the future? JAMA 2005; 293: 979-86.
  • 22. Lars Wallentin L, Kristensen SD, Anderson JL, Tubaro M, Sendon JL, Granger CB, et al. How can we optimize the processes of care for acute coronary syndromes to improve outcomes? Am Heart J 2014; 168: 622-31.
  • 23. Zahn R, Schiele R, Schneider S, Gitt AK, Wienbergen H, Seidl K, et al. Decreasing hospital mortality between 1994 and 1998 in patients with acute myocardial infarction treated with primary angioplasty but not in patients treated with intravenous thrombolysis. Results from the pooled data of the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) Registry and the Myocardial Infarction Registry (MIR). J Am Coll Cardiol 2000; 36: 2064-71.
  • 24. Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012; 33: 2569-619.
  • 25. Fitchett DH, Theroux P, Brophy JM, Cantor WJ, Cox JL, Gupta M, et al. Assessment and management of acute coronary syndromes (ACS): a Canadian perspective on current guideline-recommended treatment-part 2: ST-segment elevation myocardial infarction. Can J Cardiol 2011; 27: S402-12.
  • 26. Juliard JM, Golmard JL, Ducrocq G, Himbert D, Aubry P, Garbarz E, et al. Universal reperfusion therapy can be implemented: lessons from 20 years of management of patients admitted within 6 hours of symptom onset with ST-segment elevation acute myocardial infarction. Arch Cardiovasc Dis 2009; 102: 259-67.
  • 27. Charpentier S, Celse D, Cambou JP, Lauque D, Carrie D, Galinier M, et al. Evaluation of therapeutic strategies for myocardial infarction: the ESTIM Midi-Pyrenees survey. Arch Mal Coeur Vaiss 2005; 98: 1143-8.
  • 28. Smith JG, Wieloch M, Koul S, Braun OÖ, Lumsden J, Rydell E, et al. Triple antithrombotic therapy following an acute coronary syndrome: prevalence, outcomes and prognostic utility of the HASBLED score. EuroIntervention 2012; 8: 672-8.
  • 29. Fitchett DH, Theroux P, Brophy JM, Cantor WJ, Cox JL, Gupta M, et al. Assessment and management of acute coronary syndromes (ACS): a Canadian perspective on current guideline-recommended treatment-part 1: non-ST-segment elevation ACS. Can J Cardiol 2011; 27: S387-401.
  • 30. Fox KA, Steg PG, Eagle KA, Goodman SG, Anderson FA Jr, Granger CB, et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006. JAMA 2007; 297: 1892-900.
  • 31. Yan AT, Yan RT, Tan M, Fung A, Cohen EA, Fitchett DH, et al. Management patterns in relation to risk stratification among patients with non-ST elevation acute coronary syndromes. Arch Intern Med 2007; 167: 1009-16.
  • 32. Rosengren A, Wallentin L, Simoons M, Gitt AK, Behar S, Battler A, et al. Age, clinical presentation, and outcome of acute coronary syndromes in the Euro Heart Acute Coronary Syndrome Survey. Eur Heart J 2005; 27: 789-95.
  • 33. Goodman SG, Huang W, Yan AT, Budaj A, Kennelly BM, Gore JM, et al. The expanded global registry of acute coronary events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes. Am Heart J 2009; 158: 193-201.
  • 34. Amsterdam EA, Peterson ED, Ou FS, Newby LK, Pollack CV Jr, Gibler WB, et al., Comparative trends in guidelines adherence among patients with non-ST segment elevation acute coronary syndromes treated with invasive versus conservative management strategies: results from the CRUSADE quality improvement initiative. Am Heart J 2009; 158: 748-54.
  • 35. The ACCESS Investigators. Management of acute coronary syndromes in developing countries: acute coronary events-a multinational survey of current management strategies. Am Heart J 2011; 162: 852-9.
  • 36. Mehta RH, Chen AY, Alexander KP, Ohman EM, Roe MT, Peterson ED. Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome. Circulation 2015; 131: 980-7.
  • 37. King S, Short M, Harmon C. Glycoprotein IIb/IIIa inhibitors: The resurgence of tirofiban. Vascul Pharmacol 2016; 78: 10-6.
  • 38. Grove EL, Würtz M, Thomas MR, Kristensen SD. Antiplatelet therapy in acute coronary syndromes. Expert Opin Pharmacother 2015; 16: 2133-47.
  • 39. Montalescot G, Dallongeville J, Van Belle E, Rouanet S, Baulac C, Degrandsart A, et al. STEMI and NSTEMI: are they so different? 1-year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry). Eur Heart J 2007; 28: 1409-17.
  • 40. Sabouret P, Asseman P, Dallongeville J, Dujardin JJ, Philippe F, Herrmann MA, et al.; CONNECT Study Investigators. Observational study of adherence to European clinical practice guidelines for the management of acute coronary syndrome in revascularized versus non-revascularized patients - the CONNECT Study. Arch Cardiovasc Dis 2010; 103: 437-46.
  • 41. EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15
  • 42. Peterson ED, Roe MT, Mulgund J, DeLong ER, Lytle BL, Brindis RG, et al. Association between hospital process performance and outcomes among patients with acute coronary syndromes. JAMA 2006; 295: 1912-20.
  • 43. Budaj A, Brieger D, Steg PG, Goodman SG, Dabbous OH, Fox KA, et al. Global patterns of use of antithrombotic and antiplatelet therapies in patients with acute coronary syndromes: insights from the Global Registry of Acute Coronary Events (GRACE). Am Heart J 2003; 146: 999-1006.
  • 44. Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet 2009; 373: 929-40.
  • 45. Moscucci M, Fox KA, Cannon CP, Klein W, Lopez-Sendon J, Montalescot G, et al. Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J 2003; 24: 1815-23.
  • 46. Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006; 114: 774-82.
  • 47. Macie C, Forbes L, Foster GA, Douketis JD. Dosing practices and risk factors for bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome. Chest 2004; 125: 1616- 21.
  • 48. Waters RE 2nd, Mahaffey KW, Granger CB, Roe MT. Current perspectives on reperfusion therapy for acute ST-segment elevation myocardial infarction: integrating pharmacologic and mechanical reperfusion strategies. Am Heart J 2003; 146: 958-68.
APA Tokgozoglu L, ERTAŞ F (2016). Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. , 900 - 915.
Chicago Tokgozoglu Lale,ERTAŞ FATİH SİNAN Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. (2016): 900 - 915.
MLA Tokgozoglu Lale,ERTAŞ FATİH SİNAN Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. , 2016, ss.900 - 915.
AMA Tokgozoglu L,ERTAŞ F Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. . 2016; 900 - 915.
Vancouver Tokgozoglu L,ERTAŞ F Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. . 2016; 900 - 915.
IEEE Tokgozoglu L,ERTAŞ F "Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study." , ss.900 - 915, 2016.
ISNAD Tokgozoglu, Lale - ERTAŞ, FATİH SİNAN. "Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study". (2016), 900-915.
APA Tokgozoglu L, ERTAŞ F (2016). Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. The Anatolian Journal of Cardiology, 16(12), 900 - 915.
Chicago Tokgozoglu Lale,ERTAŞ FATİH SİNAN Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. The Anatolian Journal of Cardiology 16, no.12 (2016): 900 - 915.
MLA Tokgozoglu Lale,ERTAŞ FATİH SİNAN Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. The Anatolian Journal of Cardiology, vol.16, no.12, 2016, ss.900 - 915.
AMA Tokgozoglu L,ERTAŞ F Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. The Anatolian Journal of Cardiology. 2016; 16(12): 900 - 915.
Vancouver Tokgozoglu L,ERTAŞ F Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study. The Anatolian Journal of Cardiology. 2016; 16(12): 900 - 915.
IEEE Tokgozoglu L,ERTAŞ F "Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study." The Anatolian Journal of Cardiology, 16, ss.900 - 915, 2016.
ISNAD Tokgozoglu, Lale - ERTAŞ, FATİH SİNAN. "Pre- and in-hospital antithrombotic management patterns and in-hospital outcomes in patients with acute coronary syndrome: data from the Turkish arm of the EPICOR study". The Anatolian Journal of Cardiology 16/12 (2016), 900-915.