Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?

Bozkurt, Hasan Hüseyin; KAPTANOĞLU TAKE, Gülnur; ERDOĞAN, Deniz; ATİK, O. Şahap; SEYMEN, CEMİLE MERVE

Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?

O. Şahap ATİK, (Gazi University)

Deniz ERDOĞAN, (Boş)

Cemile Merve SEYMEN, (Boş)

Hasan Hüseyin BOZKURT, (Boş)

Gülnur KAPTANOĞLU TAKE (Boş)

Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.)

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Yıl: 2016 Cilt: 27 Sayı: 2 Sayfa Aralığı: 62 - 67 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?

Öz:

Amaç: Bu çalışmada osteoartrit patogenezinde subkondral kemik, kıkırdak ve menisküs arasında karşılıklı etkileşim olup olmadığı araştırıldı.Hastalar ve yöntemler: Medial kompartmanda osteoartriti olan 12 kadın hasta (ort. yaş 64 yıl; dağılım 59-71 yıl) çalışmaya dahil edildi. Subkondral kemik, kıkırdak ve menisküs örnekleri total diz artroplasti cerrahisi sırasında alındı. Medial kompartmandan elde edilen dejenere doku örnekleri deney grubu olarak kullanıldı (12 subkondral kemik ve kıkırdak örneği, her biri 1x1 cm; 12 menisküs örneği, her biri 1x1 cm). Lateral kompartmandan elde edilen sağlıklı doku örnekleri kontrol grubu olarak kullanıldı (12 subkondral kemik ve kıkırdak örneği; her biri 1x1 cm; 12 menisküs örneği, her biri 1x1 cm). Dekalsifikasyon sonrası doku örnekleri ışık ve geçirimli elektron mikroskopisi ile değerlendirildi.Bulgular: Deney grubunda, subkondral kemik örneklerinin ışık mikroskobik değerlendirmesi kıkırdak-kemik geçiş bölgesinin düzensiz bir yapıda olduğunu gösterdi. Geçiş bölgesinde dejenere kıkırdak hücreleri görüldü ve kemik hücreleri önemli oranda bozulmuştu. Deney grubunda, menisküs örneklerinin ışık mikroskobik değerlendirmesi hücreler arası dokunun yer yer bozulmuş olduğunu gösterdi. Kollajen liflerde ayrılma ve yoğunlaşma belirgindi. Tüm bulgular ultra strüktürel değerlendirme ile desteklendi.Sonuç: Bulgularımıza göre, subkondral kemik, kıkırdak ve menisküsün dejenerasyonu karşılıklı etkileşim ile osteoartrit patogenezinde muhtemelen rol oynamaktadır.

Anahtar Kelime:

Konular: Ortopedi

Osteoartrit patogenezinde subkondral kemik, kıkırdak ve menisküs arasında karşılıklı etkileşim var mıdır?

Öz:

Objectives: This study aims to investigate if there is any crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis.Patients and methods: Twelve female patients (mean age 64 years; range 59 to 71 years) with osteoarthritis in medial compartment were included in the study. The samples of subchondral bone, cartilage and meniscus were obtained during total knee arthroplasty. Degenerated tissue samples obtained from medial compartment were used as the experimental group (12 samples of subchondral bone and cartilage, 1x1 cm each; and 12 samples of meniscus, 1x1 cm each). Healthy tissue samples obtained from lateral compartment were used as the control group (12 samples of subchondral bone and cartilage; 1x1 cm each; and 12 samples of meniscus, 1x1 cm each). After decalcification, tissue samples were evaluated with light and transmission electron microscopy.Results: In the experimental group, light microscopic evaluation of subchondral bone samples demonstrated that the cartilage-to-bone transition region had an irregular structure. Degenerated cartilage cells were observed in the transition region and bone cells were significantly corrupted. In the experimental group, light microscopic evaluation of the meniscus samples demonstrated that the intercellular tissue was partly corrupted. Separation and concentration of the collagen fibers were evident. All findings were supported with ultra structural evaluations.Conclusion: Our findings indicate that degeneration of subchondral bone, cartilage, and meniscus probably plays a role in the pathogenesis of osteoarthritis with crosstalk.

Anahtar Kelime:

Konular: Ortopedi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ATİK O, ERDOĞAN D, SEYMEN C, Bozkurt H, KAPTANOĞLU TAKE G (2016). Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. , 62 - 67.
Chicago	ATİK O. Şahap,ERDOĞAN Deniz,SEYMEN CEMİLE MERVE,Bozkurt Hasan Hüseyin,KAPTANOĞLU TAKE Gülnur Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. (2016): 62 - 67.
MLA	ATİK O. Şahap,ERDOĞAN Deniz,SEYMEN CEMİLE MERVE,Bozkurt Hasan Hüseyin,KAPTANOĞLU TAKE Gülnur Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. , 2016, ss.62 - 67.
AMA	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. . 2016; 62 - 67.
Vancouver	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. . 2016; 62 - 67.
IEEE	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G "Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?." , ss.62 - 67, 2016.
ISNAD	ATİK, O. Şahap vd. "Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?". (2016), 62-67.

APA	ATİK O, ERDOĞAN D, SEYMEN C, Bozkurt H, KAPTANOĞLU TAKE G (2016). Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 27(2), 62 - 67.
Chicago	ATİK O. Şahap,ERDOĞAN Deniz,SEYMEN CEMİLE MERVE,Bozkurt Hasan Hüseyin,KAPTANOĞLU TAKE Gülnur Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 27, no.2 (2016): 62 - 67.
MLA	ATİK O. Şahap,ERDOĞAN Deniz,SEYMEN CEMİLE MERVE,Bozkurt Hasan Hüseyin,KAPTANOĞLU TAKE Gülnur Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), vol.27, no.2, 2016, ss.62 - 67.
AMA	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2016; 27(2): 62 - 67.
Vancouver	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2016; 27(2): 62 - 67.
IEEE	ATİK O,ERDOĞAN D,SEYMEN C,Bozkurt H,KAPTANOĞLU TAKE G "Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?." Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 27, ss.62 - 67, 2016.
ISNAD	ATİK, O. Şahap vd. "Is there crosstalk between subchondral bone, cartilage, andmeniscus in the pathogenesis of osteoarthritis?". Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 27/2 (2016), 62-67.