Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia

Tunc, Lutfi; ALKİBAY, Turgut; GÜNERİ, Çağrı

Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia

Çağrı GÜNERİ, (1Department of Urology, LivHospital, Ankara, Turkey)

Turgut ALKİBAY, (Department of Urology, Gazi University School of Medicine, Ankara, Turkey Submitted: Accepted:)

Lütfi TUNÇ (Department of Urology, Gazi University School of Medicine, Ankara, Turkey Submitted: Accepted:)

Turkish Journal of Urology

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Yıl: 2016 Cilt: 42 Sayı: 3 Sayfa Aralığı: 168 - 177 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia

Öz:

Objective: The study aims to evaluate the correlation of testicular sperm extraction (TESE) and histopathology with various features of non-obstructive azoospermia (NOA) cases who consulted to our universitybased infertility clinic, and the probability of prompting couples about TESE success and to investigate the cost reduction chance through cost-beneficial aspects. Material and methods: One hundred and twenty-five patients were enrolled in this study. Age, unprotected intercourse period, age of puberty, and concomittant diseases were noted. Testicular volumes were measured. The correlations between genetic test results and serum levels of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), free testosterone, prolactine were investigated.Results: The incidence of NOA among infertile men was found to be 15.1%. Median age of the cases was 33.1 years. Decrease in TESE success rate was seen in the group aged >30, and those who practiced unprotected intercourse for more than 10 years. TESE success rate was 40 percent. The required negative correlation between FSH levels, and testicular volume was not observed when the patient had additional diseases and/or genitourinary surgery. FSH and LH levels were significantly different between TESE- positive and negative groups (p=0.006, and p=0.001 respectively). Success rate in bilateral TESE group was 14.2%, and 96% of TESE- negative patients had bilateral TESE. Fifteen of 118 patients had Y chromosome microdeletions. These results were similar in both TESE- positive and negative group.Conclusion: None of the parameters investigated herein predicted succesful TESE outcomes. However, in cases with increased FSH and AZFa/AZFb deletion before application of bilateral TESE, in cases of increased FSH and AZFa/AZFb deletion, detailed information should be given to these patients about low success rates and risk of disease inheritance which may reduce procedural costs. Knowing groups with poor prognosis, may help rearrangement of the appropriation of infertility in health policies

Anahtar Kelime:

Konular: Üroloji ve Nefroloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜNERİ Ç, ALKİBAY T, Tunc L (2016). Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. , 168 - 177.
Chicago	GÜNERİ Çağrı,ALKİBAY Turgut,Tunc Lutfi Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. (2016): 168 - 177.
MLA	GÜNERİ Çağrı,ALKİBAY Turgut,Tunc Lutfi Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. , 2016, ss.168 - 177.
AMA	GÜNERİ Ç,ALKİBAY T,Tunc L Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. . 2016; 168 - 177.
Vancouver	GÜNERİ Ç,ALKİBAY T,Tunc L Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. . 2016; 168 - 177.
IEEE	GÜNERİ Ç,ALKİBAY T,Tunc L "Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia." , ss.168 - 177, 2016.
ISNAD	GÜNERİ, Çağrı vd. "Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia". (2016), 168-177.

APA	GÜNERİ Ç, ALKİBAY T, Tunc L (2016). Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. Turkish Journal of Urology, 42(3), 168 - 177.
Chicago	GÜNERİ Çağrı,ALKİBAY Turgut,Tunc Lutfi Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. Turkish Journal of Urology 42, no.3 (2016): 168 - 177.
MLA	GÜNERİ Çağrı,ALKİBAY Turgut,Tunc Lutfi Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. Turkish Journal of Urology, vol.42, no.3, 2016, ss.168 - 177.
AMA	GÜNERİ Ç,ALKİBAY T,Tunc L Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. Turkish Journal of Urology. 2016; 42(3): 168 - 177.
Vancouver	GÜNERİ Ç,ALKİBAY T,Tunc L Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia. Turkish Journal of Urology. 2016; 42(3): 168 - 177.
IEEE	GÜNERİ Ç,ALKİBAY T,Tunc L "Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia." Turkish Journal of Urology, 42, ss.168 - 177, 2016.
ISNAD	GÜNERİ, Çağrı vd. "Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia". Turkish Journal of Urology 42/3 (2016), 168-177.