Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri

Eroğlu, Erdal; öztürk, bilgin; YAMAN, Hakan Levent; DEMİRKAYA, Şeref; karadaş, ömer

Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri

Ömer KARADAŞ, (Erzincan Military Hospital, Neurology Service, Erzincan, Turkey)

Hakan Levent YAMAN, (Kartal Education and Research Hospital, Department of Neurology, Istanbul, Turkeyy)

Bilgin ÖZTÜRK, (Gulhane Military Medical Academy, Department of Neurology, Ankara, Turkey)

Erdal EROĞLU, (Gulhane Military Medical Academy, Department of Neurology, Ankara, Turkey)

Şeref DEMİRKAYA (Gulhane Military Medical Academy, Department of Neurology, Ankara, Turkey)

Turkish Neurosurgery

13 0

Yıl: 2014 Cilt: 24 Sayı: 5 Sayfa Aralığı: 704 - 709 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri

Öz:

AmAÇ: Çalışmada, serebral otoregülasyonun bir göstergesi olan vazomotor reaktivite (VMR)'nin, migren proflaksisinde topiramat tedavisine yanıtları ve topiramat tedavisi sırasında serebral hemodinamideki değişikliklerin incelenmesi amaçlanmıştır. yÖNTEm VE GEREÇLER: Çalışmaya, 20 migren hastası (Grup 1) ve 20 sağlıklı kontrol deneği (Grup 2) alındı. Her iki grupta transkraniyal Doppler (TCD) yapıldı. Migrenli hastalara topiramat başlandı. Tedavi sonrası 2. ayda TCD parametreleri tekrar değerlendirildi. BuLGuLAR: Topiramat tedavisi öncesi migren grubunda OSA bazal akım hızları ile VMR değerleri istatistiksel olarak anlamlı derecede (p<0,05) yüksek bulundu. Migren grubunda topiramat tedavi sonrası saptanan, sağ ve sol OSA'dan elde edilen bazal akım hızları ile VMR değerleri, kontrol grubu ile karşılaştırıldığında farklılık saptanmadı (p>0,05). soNuÇ: Migrenli hastaların proflaktik tedavisinde, topiramatın iyi bir seçenek olduğu ve serebrovasküler otonomik kontrolün regülasyonunda rol oynadığı söylenebilir.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Endokrinoloji ve Metabolizma Genel ve Dahili Tıp Klinik Nöroloji Nörolojik Bilimler Üroloji ve Nefroloji Hematoloji Pediatri

The Effects of Topiramate Therapy on Cerebral Metabolism in Migraine with Aura Patients

Öz:

AIm: Topiramate is an antiepileptic drug with multiple mechanisms of action that is also used for migraine prophylaxis. This study aimed to investigate the efficacy of topiramate therapy for migraine prophylaxis, based on vasomotor reactivity ([VMR] an indicator of cerebral autoregulation), and to identify changes in cerebral hemodynamics during the treatment.mATERIAL and mETHods: We included 20 migraine (with aura) patients (group 1) and 20 healthy controls (group 2) in the study. Transcranial Doppler monitoring was performed in both groups with patients in the supine and resting position. Using a two-sided temporal window at depths of 45-60 mm for the middle cerebral artery (MCA) and depths of 60-70 mm for the posterior cerebral artery (PCA), basal flow rates and VMR values were measured. Group 1 initially received 25 mg/d of topiramate orally, and then the dose was increased 25 mg every week. At the fourth week; the optimal dose was increased to 50 mg b.i.d. and the treatment was continued at this dose. Transcranial Doppler parameters were re-evaluated 2 months after treatment. In addition, the number of attacks per month, duration of pain, and visual analog scale (VAS) scores obtained before the treatment and 2 months after the treatment in group 1 were compared.REsuLTs: Basal flow rates and VMR values recorded from the right and left MCA in group 1 were significantly higher than those in the control group (P < 0.05). Flow velocities obtained from the right and left MCA, and the VMR values in group 1 after topiramate treatment did not differ significantly from those in the control group (P > 0.05). In addition, the number of attacks, duration of pain, and VAS scores in group 1 were significantly lower after the treatment than before the treatment (P < 0.05).CoNCLusIoN: Topiramate is an effective prophylactic treatment in migraine with aura patients and appeared to play a positive role in the regulation of cerebrovascular autonomic control.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Endokrinoloji ve Metabolizma Genel ve Dahili Tıp Klinik Nöroloji Nörolojik Bilimler Üroloji ve Nefroloji Hematoloji Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	karadaş ö, YAMAN H, öztürk b, Eroğlu E, DEMİRKAYA Ş (2014). Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. , 704 - 709.
Chicago	karadaş ömer,YAMAN Hakan Levent,öztürk bilgin,Eroğlu Erdal,DEMİRKAYA Şeref Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. (2014): 704 - 709.
MLA	karadaş ömer,YAMAN Hakan Levent,öztürk bilgin,Eroğlu Erdal,DEMİRKAYA Şeref Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. , 2014, ss.704 - 709.
AMA	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. . 2014; 704 - 709.
Vancouver	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. . 2014; 704 - 709.
IEEE	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş "Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri." , ss.704 - 709, 2014.
ISNAD	karadaş, ömer vd. "Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri". (2014), 704-709.

APA	karadaş ö, YAMAN H, öztürk b, Eroğlu E, DEMİRKAYA Ş (2014). Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. Turkish Neurosurgery, 24(5), 704 - 709.
Chicago	karadaş ömer,YAMAN Hakan Levent,öztürk bilgin,Eroğlu Erdal,DEMİRKAYA Şeref Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. Turkish Neurosurgery 24, no.5 (2014): 704 - 709.
MLA	karadaş ömer,YAMAN Hakan Levent,öztürk bilgin,Eroğlu Erdal,DEMİRKAYA Şeref Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. Turkish Neurosurgery, vol.24, no.5, 2014, ss.704 - 709.
AMA	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. Turkish Neurosurgery. 2014; 24(5): 704 - 709.
Vancouver	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri. Turkish Neurosurgery. 2014; 24(5): 704 - 709.
IEEE	karadaş ö,YAMAN H,öztürk b,Eroğlu E,DEMİRKAYA Ş "Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri." Turkish Neurosurgery, 24, ss.704 - 709, 2014.
ISNAD	karadaş, ömer vd. "Auralı Migren Hastalarında Topiramat Tedavisinin Serebral Metabolizma Üzerine Etkileri". Turkish Neurosurgery 24/5 (2014), 704-709.