Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

Demir, Selim; Serbest, Kerim; KARAOGLU, Kaan; Dural, Bayram; Turan, İbrahim; ÇOL AYVAZ, MELEK; Aliyazıcıoğlu, Yüksel

Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

Melek ÇOL AYVAZ, (Ordu Üniversitesi, Fen Edebiyat Fakültesi Kimya Bölümü Ordu Türkiye)

İbrahim TURAN, (Gümüşhane Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Genetik ve Biyomühendislik Bölümü Gmüşhane Türkiye)

Bayram DURAL, (Recep Tayyip Erdoğan Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Rize, Türkiye)

Selim DEMİR, (Karadeniz Teknik Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü Tabzon Türkiye)

Kaan KARAOGLU, (Recep Tayyip Erdoğan Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Rize, Türkiye)

Yüksel ALİYAZICIOĞLU, (Recep Tayyip Erdoğan Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Rize, Türkiye)

Kerim SERBEST (Recep Tayyip Erdoğan Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Rize, Türkiye)

Turkish Journal of Chemistry

1 0

Yıl: 2017 Cilt: 41 Sayı: 5 Sayfa Aralığı: 728 - 747 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands

Öz:

Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) transition metal complexes of 2-hydroxy-5-[(E)-(4-phenyl) diazenyl] benzaldehyde oxime and 2-hydroxy-5-[(E)-(4-nitrophenyl) diazenyl] benzaldehyde oxime ligands were synthesized and characterized through NMR, IR, ESI mass, and UV analysis. DNA binding abilities of the complexes were revealed using a UV-Vis spectrophotometer with the absorption titration and competitive binding techniques. Hydrolytic and oxidative DNA cleavage activities under different conditions were also proved. Topoisomerase I inhibition efficiencies and in vitro free radical scavenging activities of all complexes were examined. Finally, the selective cytotoxic potentials of all complexes were evaluated in human colon cancer, normal colon, and fibroblast cell lines using the water-soluble tetrazolium salt (WST-1) assay. The complexes had the ability to intercalate into stacked base pairs of DNA and topoisomerase I activity was reasonably inhibited in their presence in 0.4 mM concentrations. The abilities for scavenging of DPPH and hydroxyl radicals were found to be higher than those of known standard antioxidants (ascorbic acid, butylated hydroxyanisole, and mannitol). The results obtained from the cytotoxicity experiments are especially promising for further research, which must be carried out for the evaluation of the studied complexes as anticancer drugs.

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇOL AYVAZ M, Turan İ, Dural B, Demir S, KARAOGLU K, Aliyazıcıoğlu Y, Serbest K (2017). Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. , 728 - 747.
Chicago	ÇOL AYVAZ MELEK,Turan İbrahim,Dural Bayram,Demir Selim,KARAOGLU Kaan,Aliyazıcıoğlu Yüksel,Serbest Kerim Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. (2017): 728 - 747.
MLA	ÇOL AYVAZ MELEK,Turan İbrahim,Dural Bayram,Demir Selim,KARAOGLU Kaan,Aliyazıcıoğlu Yüksel,Serbest Kerim Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. , 2017, ss.728 - 747.
AMA	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. . 2017; 728 - 747.
Vancouver	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. . 2017; 728 - 747.
IEEE	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K "Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands." , ss.728 - 747, 2017.
ISNAD	ÇOL AYVAZ, MELEK vd. "Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands". (2017), 728-747.

APA	ÇOL AYVAZ M, Turan İ, Dural B, Demir S, KARAOGLU K, Aliyazıcıoğlu Y, Serbest K (2017). Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. Turkish Journal of Chemistry, 41(5), 728 - 747.
Chicago	ÇOL AYVAZ MELEK,Turan İbrahim,Dural Bayram,Demir Selim,KARAOGLU Kaan,Aliyazıcıoğlu Yüksel,Serbest Kerim Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. Turkish Journal of Chemistry 41, no.5 (2017): 728 - 747.
MLA	ÇOL AYVAZ MELEK,Turan İbrahim,Dural Bayram,Demir Selim,KARAOGLU Kaan,Aliyazıcıoğlu Yüksel,Serbest Kerim Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. Turkish Journal of Chemistry, vol.41, no.5, 2017, ss.728 - 747.
AMA	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. Turkish Journal of Chemistry. 2017; 41(5): 728 - 747.
Vancouver	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands. Turkish Journal of Chemistry. 2017; 41(5): 728 - 747.
IEEE	ÇOL AYVAZ M,Turan İ,Dural B,Demir S,KARAOGLU K,Aliyazıcıoğlu Y,Serbest K "Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands." Turkish Journal of Chemistry, 41, ss.728 - 747, 2017.
ISNAD	ÇOL AYVAZ, MELEK vd. "Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands". Turkish Journal of Chemistry 41/5 (2017), 728-747.