Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years
Yıl: 2017 Cilt: 16 Sayı: 4 Sayfa Aralığı: 165 - 170 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022
Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years
Öz: Aim: In this study, we aimed to determine the effect of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on one-year mortality in patients with hip fractures and aged over 60 years.Materials and Methods: The S72.00, S72.10, and S72.20 codes were screened according to International Classification of Disease-10, and 560 patients were included as cases of hip fractures. Blood counts on admission and clinical data were obtained from medical data. Predictors of one-year mortality were evaluated.Results: In total, 116 out of 560 patients (20.7%) included in the study died during the one-year follow-up. When the patients' characteristics were compared according to one-year mortality (survivor and non-survivor groups), significant differences were detected for age, lymphocyte count, NLR, and PLR (p<0.05). When a Cox regression model was created to assess the factors predicting one-year mortality, the hazard ratios of NLR and PLR were 1.059 (1.022-1.097, p=0.002) and 0.997 (0.994-0999, p=0.01), respectively.Conclusion: In the study, in predict mortality among patients aged over 60 years and who had hip fractures, the NLR and PLR were observed to be higher in the survivor group than in the non-survivor group. However, when the specificity of these values is considered, it is obvious that they are not sufficiently reliable for clinical use.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Vidan M, Serra JA, Moreno C, Riquelme G, Ortiz J. Efficacy of a comprehensive geriatric intervention in older patients hospitalized for hip fracture: a randomized, controlled trial. J Am Geriatr Soc 2005; 53: 1476-82. [CrossRef]
- 2. Panula J, Pihlajamäki H, Mattila VM, Jaatinen P, Vahlberg T, Aarnio P, et al. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord 2011; 12: 105. [CrossRef]
- 3. Ariza-Vega P, Kristensen MT, Martín-Martín L, Jiménez-Moleón JJ. Predictors of long-term mortality in older people with hip fracture. Arch Phys Med Rehabil 2015; 96: 1215-21. [CrossRef]
- 4. Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 2012; 43: 676-85. [CrossRef]
- 5. Soylu K, Gedikli Ö, Ekşi A, Avcıoğlu Y, Soylu A, Yüksel S, et al. Neutrophil-to-lymphocyte ratio for the assessment of hospital mortality in patients with acute pulmonary embolism. Arch Med Sci 2016; 12: 95-100. [CrossRef]
- 6. Wang F, Hu S, Ding Y, Ju X, Wang L, Lu Q, et al. Neutrophil-to-Lymphocyte Ratio and 30-Day Mortality in Patients with Acute Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 2016; 25: 182-7. [CrossRef]
- 7. Wasilewski J, Pyka L, Hawranek M, Osadnik T, Kurek A, Skrzypek M, et al. Prognostic value of neutrophil to lymphocyte ratio in predicting longterm mortality in patients with ischemic and nonischemic heart failure. Pol Arch Med Wewn 2016; 126: 166-73. [CrossRef]
- 8. Toprak C, Tabakci MM, Simsek Z, Arslantas U, Durmus HI, Ocal L, et al. Platelet/lymphocyte ratio was associated with impaired myocardial perfusion and both in-hospital and long-term adverse outcome in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention. Postepy Kardiol Interwencyjnej 2015; 11: 288-97. [CrossRef]
- 9. Koh CH, Bhoo-Pathy N, Ng KL, Jabir RS, Tan GH, See MH, et al. Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer. Br J Cancer 2015; 113: 150-8. [CrossRef]
- 10. Vaughan-Shaw PG, Rees JR, King AT. Neutrophil lymphocyte ratio in outcome prediction after emergency abdominal surgery in the elderly. Int J Surg 2012; 10: 157-62. [CrossRef]
- 11. Forget P, Moreau N, Engel H, Cornu O, Boland B, De Kock M, et al. The neutrophil-to-lymphocyte ratio (NLR) after surgery for hip fracture (HF). Arch Gerontol Geriatr 2015; 60: 366-71. [CrossRef]
- 12. Sedlar M, Kvasnicka J, Krska Z, Tománková T, Linhart A. Early and subacute inflammatory response and long term survival after hip trauma and surgery. Arch Gerontol Geriatr 2015; 60: 431-6. [CrossRef]
- 13. Zahorec R. Ratio of neutrophil to lymphocyte counts-Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-147.
- 14. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 1999; 159: 857-63. [CrossRef]
- 15. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215- 20. [CrossRef]
- 16. Kaya MG, Akpek M, Lam YY, Yarlioglues M, Celik T, Gunebakmaz O, et al. Prognostic value of neutrophil/lymphocyte ratio in patients with ST-elevated myocardial infarction undergoing primary coronary intervention: A prospective, multicenter study. Int J Cardiol 2013; 168: 1154-9. [CrossRef]
- 17. Gunaldi M, Goksu S, Erdem D, Gunduz S, Okuturlar Y, Tiken E, et al. Prognostic impact of platelet/lymphocyte and neutrophil/lymphocyte ratios in patients with gastric cancer: a multicenter study. Int J Clin Exp Med 2015; 8: 5937-42.
- 18. Kahn JH, Magauran B. Trends in geriatric emergency medicine. Emerg Med Clin N Am 2006; 24: 243-60. [CrossRef]
- 19. Narang AT, Sikka R. Resuscitation of the elderly. Emerg Med Clin N Am 2006; 24: 261-72. [CrossRef]
- 20. Heron M. Deaths: Leading causes for 2006. Nat Vital Stat Rep 2010; 58: 1. 21. Birnbaumer Diane M. The elder patient. In: Marx John A. Rosen's emergency medicine: concepts and clinical practice. 8th. ed. Philadelphia: ElsevierSounders; 2014: 2351-5.
- 22. Gürsoy OM, Karakoyun S, Kalçık M, Gökdeniz T, Yesin M, Gündüz S, et al. Usefulness of novel hematologic inflammatory parameters to predict prosthetic mitral valve. Am J Cardiol 2014; 113: 860-4. [CrossRef]
- 23. Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012; 17: 216-22. [CrossRef]
- 24. Azab B, Shah N, Akerman M, McGinn Jr JT. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-STelevation myocardial infarction. J Thromb Thrombolysis 2012; 34: 326-34. [CrossRef]
- 25. Ferroni P, Riondino S, Formica V, Cereda V, Tosetto L, La Farina F, et al. Venous thromboembolism risk prediction in ambulatory cancer patients: clinical significance of plate/lymphocyte ratio and platelet/lymphocyte ratio. Int J Cancer 2015; 136: 1234-40. [CrossRef]
- 26. Turkmen K, Erdur FM, Ozcicek F, Ozcicek A, Akbas EM, Ozbicer A, et al. Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodial Int 2013; 17: 391-6. [CrossRef]
- 27. Neofytou K, Smyth EC, Giakoustidis A, Khan AZ, Cunningham D, Mudan S. Elevated platelet to lymphocyte ratio predicts poor prognosis after hepatectomy for liver-only colorectal metastases, and it is superior to neutrophil to lymphocyte ratio as an adverse prognostic factor. Med Oncol 2014; 31: 239. [CrossRef]
| APA | EMEKTAR E, ÇORBACIOĞLU Ş, DAGAR S, UZUNOSMANOĞLU H, Şafak T, ÇEVİK Y (2017). Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. , 165 - 170. |
| Chicago | EMEKTAR Emine,ÇORBACIOĞLU Şeref Kerem,DAGAR Seda,UZUNOSMANOĞLU HÜSEYİN,Şafak Tuba,ÇEVİK Yunsur Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. (2017): 165 - 170. |
| MLA | EMEKTAR Emine,ÇORBACIOĞLU Şeref Kerem,DAGAR Seda,UZUNOSMANOĞLU HÜSEYİN,Şafak Tuba,ÇEVİK Yunsur Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. , 2017, ss.165 - 170. |
| AMA | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. . 2017; 165 - 170. |
| Vancouver | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. . 2017; 165 - 170. |
| IEEE | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y "Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years." , ss.165 - 170, 2017. |
| ISNAD | EMEKTAR, Emine vd. "Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years". (2017), 165-170. |
| APA | EMEKTAR E, ÇORBACIOĞLU Ş, DAGAR S, UZUNOSMANOĞLU H, Şafak T, ÇEVİK Y (2017). Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. Eurasian Journal of Emergency Medicine, 16(4), 165 - 170. |
| Chicago | EMEKTAR Emine,ÇORBACIOĞLU Şeref Kerem,DAGAR Seda,UZUNOSMANOĞLU HÜSEYİN,Şafak Tuba,ÇEVİK Yunsur Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. Eurasian Journal of Emergency Medicine 16, no.4 (2017): 165 - 170. |
| MLA | EMEKTAR Emine,ÇORBACIOĞLU Şeref Kerem,DAGAR Seda,UZUNOSMANOĞLU HÜSEYİN,Şafak Tuba,ÇEVİK Yunsur Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. Eurasian Journal of Emergency Medicine, vol.16, no.4, 2017, ss.165 - 170. |
| AMA | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. Eurasian Journal of Emergency Medicine. 2017; 16(4): 165 - 170. |
| Vancouver | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years. Eurasian Journal of Emergency Medicine. 2017; 16(4): 165 - 170. |
| IEEE | EMEKTAR E,ÇORBACIOĞLU Ş,DAGAR S,UZUNOSMANOĞLU H,Şafak T,ÇEVİK Y "Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years." Eurasian Journal of Emergency Medicine, 16, ss.165 - 170, 2017. |
| ISNAD | EMEKTAR, Emine vd. "Prognostic Value of the Neutrophil-Lymphocyte and Platelet- Lymphocyte Ratios in Predicting One-Year Mortality in Patients with Hip Fractures and Aged Over 60 Years". Eurasian Journal of Emergency Medicine 16/4 (2017), 165-170. |
