Seasonal vitamin D status and endothelial function in healthcare workers

Özlem HALİLOĞLU, (Marmara Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye)
Tolga KASACI, (Marmara Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, İstanbul, Türkiye)
Dilek YAVUZ (Marmara Üniversitesi Tıp Fakültesi, Endokrinoloji ve Metabolizma Ana Bilim Dalı, İstanbul, Türkiye)
Turkish Journal of Medical Sciences
0 0
Yıl: 2016 Cilt: 46 Sayı: 1 Sayfa Aralığı: 72 - 78 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Seasonal vitamin D status and endothelial function in healthcare workers

Öz:
Background/aim: Healthcare workers have long working hours indoors and are at risk of vitamin D deficiency. The aim of this study was to determine seasonal vitamin D status and its relationship with early atherosclerotic markers, endothelial function, and carotid intima-media thickness (CIMT) in healthcare workers of Marmara University Hospital, İstanbul. Materials and methods: One hundred and ninety healthy volunteer healthcare workers and 66 nonmedical volunteers of Marmara University Hospital were included in the study and 25-hydroxyvitamin D (25(OH)D), calcium, intact parathyroid hormone (PTH), endothelial function, and CIMT were measured twice during winter and summer seasons. Results: Mean vitamin D levels were 20 ng/mL in summer and 16.4 ng/mL in winter. Out of the healthcare workers, 48.9% were vitamin D deficient at the end of summer and 71.5% in winter. Flow-mediated dilation (FMD) values were similar in both groups in both seasons; however, FMD values of 64 healthcare workers in summer were significantly higher than in winter. Serum 25(OH)D was positively associated with FMD (r = 0.1797, P = 0.0441) and negatively correlated with serum PTH (r = 0.2459, P < 0.0001). A negative correlation between FMD and serum PTH (r = 0.1757, P = 0.0473) was observed. Conclusion: Vitamin D levels of healthcare workers are very low, even in summer time. Healthcare workers must be considered a group at major risk for vitamin D deficiency.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, Kochupillai N. Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 2000; 72: 472–475.
  • 2. McGrath JJ, Kimlin MG, Saha S, Eyles DW, Parisi AV. Vitamin D insufficiency in south-east Queensland. Med J Aust 2001; 174: 150–151.
  • 3. Gannage-Yared MH, Chemali R, Yaacoub N, Halaby G. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856–1862.
  • 4. Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am 2010; 39: 287–301.
  • 5. Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004. Arch Intern Med 2009; 169: 626–632.
  • 6. Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010; 39: 381–400.
  • 7. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007; 85: 1586–1591.
  • 8. Garland CF, Garland FC, Gorham ED. Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am J Clin Nutr 1991; 54: 193S–201S.
  • 9. Bertone-Johnson ER, Chen WY, Holick MF, Hollis BW, Colditz GA, Willett WC, Hankinson SE. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 1991–1997.
  • 10. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009; 94: 26–34.
  • 11. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004; 80: 1717S–1720S.
  • 12. Tanaka Y, Seino Y, Ishida M, Yamaoka K, Satomura K, Yabuuchi H, Imura H. Effect of 1,25-dihydroxyvitamin D3 on insulin secretion: direct or mediated? Endocrinology 1986; 118: 1971– 1976.
  • 13. Bouillon R. Vitamin D as potential baseline therapy for blood pressure control. Am J Hypertens 2009; 22: 816.
  • 14. Lane HA, Smith JC, Davies JS. Noninvasive assessment of preclinical atherosclerosis. Vasc Health Risk Manag 2006; 2: 19–30.
  • 15. O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002; 90: 18L–21L.
  • 16. Haney EM, Stadler D, Bliziotes MM. Vitamin D insufficiency in internal medicine residents. Calcif Tissue Int 2005; 76: 11– 16.
  • 17. Mahdy S, Al-Emadi SA, Khanjar IA, Hammoudeh MM, Sarakbi HA, Siam AM, Abdelrahman MO. Vitamin D status in health care professionals in Qatar. Saudi Med J 2010; 31: 74–77.
  • 18. Arya V, Bhambri R, Godbole MM, Mithal A. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 2004; 15: 56–61.
  • 19. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M et al. Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007; 23: 75–80.
  • 20. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911–1930.
  • 21. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, GerhardHerman M, Herrington D et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257–265.
  • 22. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002; 112: 659–662.
  • 23. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53–58.
  • 24. Stamp TC, Round JM. Seasonal changes in human plasma levels of 25-hydroxyvitamin D. Nature 1974; 247: 563–565.
  • 25. Vanderschueren D, Gevers G, Raymaekers G, Devos P, Dequeker J. Sex- and age-related changes in bone and serum osteocalcin. Calcif Tissue Int 1990; 46: 179–182. 26. Harris SS, Dawson-Hughes B. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women. Am J Clin Nutr 1998; 67: 1232–1236.
  • 27. Cinar N, Harmanci A, Yildiz BO, Bayraktar M. Vitamin D status and seasonal changes in plasma concentrations of 25-hydroxyvitamin D in office workers in Ankara, Turkey. Eur J Intern Med 2013.
  • 28. Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007; 49: 1063–1069.
  • 29. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007; 20: 713–719.
  • 30. Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens 2009; 27: 1948–1954.
  • 31. Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L, Kavtaradze N, Uphoff I, Hooper C, Tangpricha V et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 2011; 58: 186–192.
  • 32. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension 2011; 57: 63–69.
  • 33. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, Toprak A, Yazici D, Sancak S, Deyneli O et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 2009; 94: 4023–4030.
  • 34. Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, Arcaro G. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol (Oxf) 2006; 65: 593–597.
  • 35. Carrelli AL, Walker MD, Lowe H, McMahon DJ, Rundek T, Sacco RL, Silverberg SJ. Vitamin D deficiency is associated with subclinical carotid atherosclerosis: The Northern Manhattan study. Stroke 2011; 42: 2240–2205.
  • 36. Blondon M, Sachs M, Hoofnagle AN, Ix JH, Michos ED, Korcarz C, Gepner AD, Siscovick DS, Kaufman JD, Stein JH et al. 25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol 2013; 33: 2639–2645.
APA Haliloglu O, KASACI T, YAVUZ D (2016). Seasonal vitamin D status and endothelial function in healthcare workers. , 72 - 78.
Chicago Haliloglu Ozlem,KASACI Tolga,YAVUZ Dilek Seasonal vitamin D status and endothelial function in healthcare workers. (2016): 72 - 78.
MLA Haliloglu Ozlem,KASACI Tolga,YAVUZ Dilek Seasonal vitamin D status and endothelial function in healthcare workers. , 2016, ss.72 - 78.
AMA Haliloglu O,KASACI T,YAVUZ D Seasonal vitamin D status and endothelial function in healthcare workers. . 2016; 72 - 78.
Vancouver Haliloglu O,KASACI T,YAVUZ D Seasonal vitamin D status and endothelial function in healthcare workers. . 2016; 72 - 78.
IEEE Haliloglu O,KASACI T,YAVUZ D "Seasonal vitamin D status and endothelial function in healthcare workers." , ss.72 - 78, 2016.
ISNAD Haliloglu, Ozlem vd. "Seasonal vitamin D status and endothelial function in healthcare workers". (2016), 72-78.
APA Haliloglu O, KASACI T, YAVUZ D (2016). Seasonal vitamin D status and endothelial function in healthcare workers. Turkish Journal of Medical Sciences, 46(1), 72 - 78.
Chicago Haliloglu Ozlem,KASACI Tolga,YAVUZ Dilek Seasonal vitamin D status and endothelial function in healthcare workers. Turkish Journal of Medical Sciences 46, no.1 (2016): 72 - 78.
MLA Haliloglu Ozlem,KASACI Tolga,YAVUZ Dilek Seasonal vitamin D status and endothelial function in healthcare workers. Turkish Journal of Medical Sciences, vol.46, no.1, 2016, ss.72 - 78.
AMA Haliloglu O,KASACI T,YAVUZ D Seasonal vitamin D status and endothelial function in healthcare workers. Turkish Journal of Medical Sciences. 2016; 46(1): 72 - 78.
Vancouver Haliloglu O,KASACI T,YAVUZ D Seasonal vitamin D status and endothelial function in healthcare workers. Turkish Journal of Medical Sciences. 2016; 46(1): 72 - 78.
IEEE Haliloglu O,KASACI T,YAVUZ D "Seasonal vitamin D status and endothelial function in healthcare workers." Turkish Journal of Medical Sciences, 46, ss.72 - 78, 2016.
ISNAD Haliloglu, Ozlem vd. "Seasonal vitamin D status and endothelial function in healthcare workers". Turkish Journal of Medical Sciences 46/1 (2016), 72-78.
Sayfa Oluşturulma Tarihi
23-04-2024 3:23

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları