Yıl: 2016 Cilt: 46 Sayı: 1 Sayfa Aralığı: 166 - 173 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts

Öz:
Background/aim: There is no information on the dose response relationship of curcumin on the hemodynamic variables of the heart at the organ level in isolated perfused rat hearts. We aimed to investigate the effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Materials and methods: Rats were randomly divided into 9 groups. The isolated rat heart was retrogradely perfused with modified Krebs Henseleit solution. After the stabilization period, each group was administered one of the following treatments for 25 min: saline, dimethyl sulfoxide, and curcumin (0.2 µM, 1 µM, and 5 µM); atropine (1 µM); atropine (1 µM) + curcumin (1 µM); L-NAME (100 µM); or L-NAME (100 µM) + curcumin (1 µM). Hemodynamic variables of the heart were measured. Results: Curcumin at dose of 1 µM decreased the heart rate (from 271 ± 11.1 to 200.4 ± 14.3 beats/min, P = 0.011) but increased enddiastolic pressure (from 7.0 ± 0.4 to 54.6 ± 7.9 mmHg, P = 0.0008). A dose of 5 µM curcumin caused a decrease in the developed pressure (from 87.58 ± 9.0 to 65.40 ± 7.0 mmHg, P = 0.047) but an increase in the end-diastolic pressure (from 6.8 ± 0.6 to 48.9 ± 7.7 mmHg, P = 0.005). Atropine (1 µM) reversed the effects of curcumin on the heart. Conclusion: Our results suggest that curcumin produces dose-dependent negative chronotropic and inotropic effects in isolated perfused rat hearts.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kilinc E, KAYGISIZ Z, BENEK B, GÜMÜŞTEKİN K (2016). Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. , 166 - 173.
Chicago Kilinc Erkan,KAYGISIZ Ziya,BENEK Bedri Selim,GÜMÜŞTEKİN Kenan Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. (2016): 166 - 173.
MLA Kilinc Erkan,KAYGISIZ Ziya,BENEK Bedri Selim,GÜMÜŞTEKİN Kenan Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. , 2016, ss.166 - 173.
AMA Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. . 2016; 166 - 173.
Vancouver Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. . 2016; 166 - 173.
IEEE Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K "Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts." , ss.166 - 173, 2016.
ISNAD Kilinc, Erkan vd. "Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts". (2016), 166-173.
APA Kilinc E, KAYGISIZ Z, BENEK B, GÜMÜŞTEKİN K (2016). Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Turkish Journal of Medical Sciences, 46(1), 166 - 173.
Chicago Kilinc Erkan,KAYGISIZ Ziya,BENEK Bedri Selim,GÜMÜŞTEKİN Kenan Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Turkish Journal of Medical Sciences 46, no.1 (2016): 166 - 173.
MLA Kilinc Erkan,KAYGISIZ Ziya,BENEK Bedri Selim,GÜMÜŞTEKİN Kenan Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Turkish Journal of Medical Sciences, vol.46, no.1, 2016, ss.166 - 173.
AMA Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Turkish Journal of Medical Sciences. 2016; 46(1): 166 - 173.
Vancouver Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Turkish Journal of Medical Sciences. 2016; 46(1): 166 - 173.
IEEE Kilinc E,KAYGISIZ Z,BENEK B,GÜMÜŞTEKİN K "Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts." Turkish Journal of Medical Sciences, 46, ss.166 - 173, 2016.
ISNAD Kilinc, Erkan vd. "Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts". Turkish Journal of Medical Sciences 46/1 (2016), 166-173.