TY  - JOUR
TI  - Effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts
AB  - Background/aim: There is no information on the dose response relationship of curcumin on the hemodynamic variables of the heart at the organ level in isolated perfused rat hearts. We aimed to investigate the effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Materials and methods: Rats were randomly divided into 9 groups. The isolated rat heart was retrogradely perfused with modified Krebs Henseleit solution. After the stabilization period, each group was administered one of the following treatments for 25 min: saline, dimethyl sulfoxide, and curcumin (0.2 µM, 1 µM, and 5 µM); atropine (1 µM); atropine (1 µM) + curcumin (1 µM); L-NAME (100 µM); or L-NAME (100 µM) + curcumin (1 µM). Hemodynamic variables of the heart were measured. Results: Curcumin at dose of 1 µM decreased the heart rate (from 271 ± 11.1 to 200.4 ± 14.3 beats/min, P = 0.011) but increased enddiastolic pressure (from 7.0 ± 0.4 to 54.6 ± 7.9 mmHg, P = 0.0008). A dose of 5 µM curcumin caused a decrease in the developed pressure (from 87.58 ± 9.0 to 65.40 ± 7.0 mmHg, P = 0.047) but an increase in the end-diastolic pressure (from 6.8 ± 0.6 to 48.9 ± 7.7 mmHg, P = 0.005). Atropine (1 µM) reversed the effects of curcumin on the heart. Conclusion: Our results suggest that curcumin produces dose-dependent negative chronotropic and inotropic effects in isolated perfused rat hearts.
AU  - Kilinc, Erkan
AU  - GÜMÜŞTEKİN, Kenan
AU  - BENEK, Bedri Selim
AU  - KAYGISIZ, Ziya
PY  - 2016
JO  - Turkish Journal of Medical Sciences
VL  - 46
IS  - 1
SN  - 1300-0144
SP  - 166
EP  - 173
DB  - TRDizin
UR  - http://search/yayin/detay/247801
ER  -