Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey

ERZURUM, Ferudun; ERTUĞRUL, Okan; BİLGEN, Nüket; ÇINAR KUL, BENGİ

Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey

Nüket BİLGEN, (University of Ankara)

Bengi ÇINAR KUL, (University of Ankara)

Okan ERTUĞRUL, (University of Ankara)

Ferudun ERZURUM (General Directory of Agricultural Farms (TIGEM), TR-06550 Ankara - TURKEY)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2017 Cilt: 23 Sayı: 2 Sayfa Aralığı: 339 - 342 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey

Öz:

Atların "Polisakkarit Depolama Hastalığı" (Polisaccarite Storage Myopathy, PSSM) ve "Lavanta Renkli Tay Sendromu" (Lavander Foal Syndrome, LFS) aktarılan kalıtsal hastalıklardır. PSSM-I'de, Glikojen Sentaz-1 (GYS1) geninde meydana gelen bir nokta mutasyonuna bağlı olarak enzim etkinliğinde artış şekillenmekte ve anormal polisakkaritler oluşmaktadır. Lavanta renkli tay hastalığında ise Miyozin-Va (MYO5A) geninde çerçeve kayması mutasyonuna neden olan bir bazlık delesyon sonucunda proteinde prematüre sonlanma şekillenmektedir. Sunulan araştırmada, Anadolu (n=70), Karacabey (n=70) ve Sultansuyu (n=99) Tarım İşletmeleri'nde yetiştirilen damızlık Arap atlarından temin edilmiş 239 adet kan örneği kullanılmıştır. İncelenen popülasyonda LFS ve PSSM hastalıklarıyla ilişkilendirilen mutasyonlara rastlanmamıştır

Anahtar Kelime:

Konular: Veterinerlik

Türkiye Arap Atı Popülasyonunda LFS ve PSSM-I Hastalıklarının Moleküler Taraması

Öz:

Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MYO5A) leads frame shift mutation and premature termination of the protein. In the study, a total of 239 blood samples, taken from Anadolu (n=70), Karacabey (n=70) and Sultansuyu (n=99) stud farms were screened. Diseases related mutations were not detected in the sampled Arabian horse population

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Kısa Bildiri Erişim Türü: Erişime Açık

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APA	BİLGEN N, ÇINAR KUL B, ERTUĞRUL O, ERZURUM F (2017). Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. , 339 - 342.
Chicago	BİLGEN Nüket,ÇINAR KUL BENGİ,ERTUĞRUL Okan,ERZURUM Ferudun Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. (2017): 339 - 342.
MLA	BİLGEN Nüket,ÇINAR KUL BENGİ,ERTUĞRUL Okan,ERZURUM Ferudun Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. , 2017, ss.339 - 342.
AMA	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. . 2017; 339 - 342.
Vancouver	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. . 2017; 339 - 342.
IEEE	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F "Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey." , ss.339 - 342, 2017.
ISNAD	BİLGEN, Nüket vd. "Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey". (2017), 339-342.

APA	BİLGEN N, ÇINAR KUL B, ERTUĞRUL O, ERZURUM F (2017). Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 23(2), 339 - 342.
Chicago	BİLGEN Nüket,ÇINAR KUL BENGİ,ERTUĞRUL Okan,ERZURUM Ferudun Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 23, no.2 (2017): 339 - 342.
MLA	BİLGEN Nüket,ÇINAR KUL BENGİ,ERTUĞRUL Okan,ERZURUM Ferudun Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.23, no.2, 2017, ss.339 - 342.
AMA	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2017; 23(2): 339 - 342.
Vancouver	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2017; 23(2): 339 - 342.
IEEE	BİLGEN N,ÇINAR KUL B,ERTUĞRUL O,ERZURUM F "Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 23, ss.339 - 342, 2017.
ISNAD	BİLGEN, Nüket vd. "Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 23/2 (2017), 339-342.