Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

MEDJAHED, Zineb; ATMANI-KILANI, Dina; ATMANI, Djebbar; FAUCONNIER, Marie-Laure; RICHARD, Gaëtan

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

Zineb MEDJAHED, (Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria)

Dina ATMANI-KILANI, (Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria)

Marie-Laure FAUCONNIER, (Department of Chemistry and Bioindustries, General and Organic Chemistry, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium)

Gaëtan RICHARD, (Department of Chemistry and Bioindustries, General and Organic Chemistry, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium)

Djebbar ATMANI (Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria)

Turkish Journal of Medical Sciences

1 0

Yıl: 2016 Cilt: 46 Sayı: 3 Sayfa Aralığı: 910 - 920 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

Öz:

Background/aim: The present study was designed to explore antidiabetic and hepatoprotective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo. Materials and methods: Streptozotocin (STZ)-induced diabetic rats, pretreated with the extracts (25 and 50 mg/kg), were monitored for fasting blood glucose (FBG) levels. Hepatoprotective potential was examined after injection of an excessive dose of paracetamol (10 g/60 kg) by analysis of biochemical parameters (transaminases, bilirubin), malondialdehyde (MDA) levels, and histological sections. high performance liquid chromatography analysis was also performed for partial characterization. Results: A considerable hypoglycemic effect was noticed 2 h after the STZ-induction, with a higher efficiency (P < 0.05) for FAL (68%) as compared with FAB (57%). A significant (P < 0.05) reduction in MDA was observed for paracetamol-fed mice pretreated with FAL (50 mg/kg), FAB (50 mg/kg), or both (25 mg/kg each) extracts, and the MDA levels for the three conditions were 0.290 ± 0.034, 0.340 ± 0.038, and 0.25 ± 0.058 nmoles/mg of liver tissue, respectively). Hence, simultaneous treatment provided a better protection. Histological observations confirmed the higher hepatoprotective potential of FAL over FAB extracts Conclusion: The obtained results indicate the possibility of pharmacological exploitation of F. angustifolia extracts in the treatment of diabetes and associated liver diseases.

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APA	MEDJAHED Z, ATMANI-KILANI D, FAUCONNIER M, RICHARD G, ATMANI D (2016). Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. , 910 - 920.
Chicago	MEDJAHED Zineb,ATMANI-KILANI Dina,FAUCONNIER Marie-Laure,RICHARD Gaëtan,ATMANI Djebbar Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. (2016): 910 - 920.
MLA	MEDJAHED Zineb,ATMANI-KILANI Dina,FAUCONNIER Marie-Laure,RICHARD Gaëtan,ATMANI Djebbar Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. , 2016, ss.910 - 920.
AMA	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. . 2016; 910 - 920.
Vancouver	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. . 2016; 910 - 920.
IEEE	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D "Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis." , ss.910 - 920, 2016.
ISNAD	MEDJAHED, Zineb vd. "Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis". (2016), 910-920.

APA	MEDJAHED Z, ATMANI-KILANI D, FAUCONNIER M, RICHARD G, ATMANI D (2016). Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. Turkish Journal of Medical Sciences, 46(3), 910 - 920.
Chicago	MEDJAHED Zineb,ATMANI-KILANI Dina,FAUCONNIER Marie-Laure,RICHARD Gaëtan,ATMANI Djebbar Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. Turkish Journal of Medical Sciences 46, no.3 (2016): 910 - 920.
MLA	MEDJAHED Zineb,ATMANI-KILANI Dina,FAUCONNIER Marie-Laure,RICHARD Gaëtan,ATMANI Djebbar Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. Turkish Journal of Medical Sciences, vol.46, no.3, 2016, ss.910 - 920.
AMA	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. Turkish Journal of Medical Sciences. 2016; 46(3): 910 - 920.
Vancouver	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis. Turkish Journal of Medical Sciences. 2016; 46(3): 910 - 920.
IEEE	MEDJAHED Z,ATMANI-KILANI D,FAUCONNIER M,RICHARD G,ATMANI D "Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis." Turkish Journal of Medical Sciences, 46, ss.910 - 920, 2016.
ISNAD	MEDJAHED, Zineb vd. "Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis". Turkish Journal of Medical Sciences 46/3 (2016), 910-920.