Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger

Gülbahar, Özlem; CANDANSAYAR, SELÇUK; DÖNMEZ, Refia Aslıhan; Bolay, Hayrunnisa; DERİNÖZ, Okşan

Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger

Refia Aslıhan DÖNMEZ, (Üsküdar Üniversitesi, Psikoloji Bölümü, İstanbul, Türkiye)

Selçuk CANDANSAYAR, (Gazi Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Ankara, Türkiye)

Okşan DERİNÖZ, (Gazi Üniversitesi Tıp Fakültesi Çocuk Acil Servis Bölümü, Ankara, Türkiye)

Özlem GÜLBAHAR, (Gazi Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Hayrunnisa BOLAY (Gazi Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2016 Cilt: 46 Sayı: 5 Sayfa Aralığı: 1546 - 1560 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger

Öz:

Background/aim: This study aimed to investigate the effects of early adverse life events and being raised by an ambivalent mother on rats. Materials and methods: The rats were separated into four groups: 1) the control group (n = 12), which was raised under standard care; 2) the early handling (EH) group, which was raised using an EH model (n = 16); 3) the early deprivation (ED) group, which was raised using an ED model (n = 13), and 4) the ambivalent mother (AM) group, which spent 3 h/day with a fake mother (n = 17). When they became adults, their anxiety levels, depressive-like behaviors, and memory functions were measured using the elevated plus maze test, the forced swim test, and the novel object recognition test, respectively. Their neurodevelopment was evaluated by measuring the brainderived neurotrophic factor (BDNF) levels in the prefrontal cortex, the dentate gyrus, and the cerebellum via ELISA. Results: The rats in the ED and AM groups exhibited less anxiety and depressive-like behavior than those in the control and EH groups, particularly in females. There was no significant difference between the groups in memory function or brain BDNF levels. Conclusion: Severe and ambivalent early adverse life events may decrease anxiety and depressive-like behavior in adult rats.

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Konular: Cerrahi

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APA	DÖNMEZ R, CANDANSAYAR S, DERİNÖZ O, Gülbahar Ö, Bolay H (2016). Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. , 1546 - 1560.
Chicago	DÖNMEZ Refia Aslıhan,CANDANSAYAR SELÇUK,DERİNÖZ Okşan,Gülbahar Özlem,Bolay Hayrunnisa Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. (2016): 1546 - 1560.
MLA	DÖNMEZ Refia Aslıhan,CANDANSAYAR SELÇUK,DERİNÖZ Okşan,Gülbahar Özlem,Bolay Hayrunnisa Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. , 2016, ss.1546 - 1560.
AMA	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. . 2016; 1546 - 1560.
Vancouver	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. . 2016; 1546 - 1560.
IEEE	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H "Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger." , ss.1546 - 1560, 2016.
ISNAD	DÖNMEZ, Refia Aslıhan vd. "Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger". (2016), 1546-1560.

APA	DÖNMEZ R, CANDANSAYAR S, DERİNÖZ O, Gülbahar Ö, Bolay H (2016). Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. Turkish Journal of Medical Sciences, 46(5), 1546 - 1560.
Chicago	DÖNMEZ Refia Aslıhan,CANDANSAYAR SELÇUK,DERİNÖZ Okşan,Gülbahar Özlem,Bolay Hayrunnisa Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. Turkish Journal of Medical Sciences 46, no.5 (2016): 1546 - 1560.
MLA	DÖNMEZ Refia Aslıhan,CANDANSAYAR SELÇUK,DERİNÖZ Okşan,Gülbahar Özlem,Bolay Hayrunnisa Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. Turkish Journal of Medical Sciences, vol.46, no.5, 2016, ss.1546 - 1560.
AMA	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. Turkish Journal of Medical Sciences. 2016; 46(5): 1546 - 1560.
Vancouver	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger. Turkish Journal of Medical Sciences. 2016; 46(5): 1546 - 1560.
IEEE	DÖNMEZ R,CANDANSAYAR S,DERİNÖZ O,Gülbahar Ö,Bolay H "Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger." Turkish Journal of Medical Sciences, 46, ss.1546 - 1560, 2016.
ISNAD	DÖNMEZ, Refia Aslıhan vd. "Adulthood behavioral and neurodevelopmental effects of being raised byan ambivalent mother in rats: what does not kill you makes you stronger". Turkish Journal of Medical Sciences 46/5 (2016), 1546-1560.