Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma

Akin, Senay; DORAL, Mahmut Nedim; Dönmez, Gürhan; Demirel, Haydar; ERİŞGEN, Gülriz; Utku, Burkay; Korkusuz, Feza

Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma

Burkay UTKU, (Ankara Atatürk Eğitim ve Araştırma Hastanesi, Spor Bilimleri Bölümü, Bilkent, Ankara)

Gürhan DÖNMEZ, (Hacettepe Üniversitesi, Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Gülriz ERİŞGEN, (TOBB ETU Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Ankara, Türkiye)

Şenay AKIN, (Hacettepe Üniversitesi, Spor Bilimleri Fakültesi, Ankara, Türkiye)

ALİ HAYDAR DEMİREL, (Hacettepe Üniversitesi, Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Feza KORKUSUZ, (Hacettepe Üniversitesi, Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Mahmut Nedim DORAL (Hacettepe Üniversitesi, Tıp Fakültesi, Spor Hekimliği Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2017 Cilt: 47 Sayı: 2 Sayfa Aralığı: 570 - 576 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma

Öz:

Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 µg mL 1 and 2.5 µg mL 1), meloxicam (0.8 µg mL 1 and 2.0 µg mL 1), and acetylsalicylic acid (final concentration 450 µm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Utku B, Dönmez G, ERİŞGEN G, Akin S, Demirel H, Korkusuz F, DORAL M (2017). Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. , 570 - 576.
Chicago	Utku Burkay,Dönmez Gürhan,ERİŞGEN Gülriz,Akin Senay,Demirel Haydar,Korkusuz Feza,DORAL Mahmut Nedim Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. (2017): 570 - 576.
MLA	Utku Burkay,Dönmez Gürhan,ERİŞGEN Gülriz,Akin Senay,Demirel Haydar,Korkusuz Feza,DORAL Mahmut Nedim Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. , 2017, ss.570 - 576.
AMA	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. . 2017; 570 - 576.
Vancouver	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. . 2017; 570 - 576.
IEEE	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M "Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma." , ss.570 - 576, 2017.
ISNAD	Utku, Burkay vd. "Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma". (2017), 570-576.

APA	Utku B, Dönmez G, ERİŞGEN G, Akin S, Demirel H, Korkusuz F, DORAL M (2017). Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences, 47(2), 570 - 576.
Chicago	Utku Burkay,Dönmez Gürhan,ERİŞGEN Gülriz,Akin Senay,Demirel Haydar,Korkusuz Feza,DORAL Mahmut Nedim Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences 47, no.2 (2017): 570 - 576.
MLA	Utku Burkay,Dönmez Gürhan,ERİŞGEN Gülriz,Akin Senay,Demirel Haydar,Korkusuz Feza,DORAL Mahmut Nedim Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences, vol.47, no.2, 2017, ss.570 - 576.
AMA	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences. 2017; 47(2): 570 - 576.
Vancouver	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences. 2017; 47(2): 570 - 576.
IEEE	Utku B,Dönmez G,ERİŞGEN G,Akin S,Demirel H,Korkusuz F,DORAL M "Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma." Turkish Journal of Medical Sciences, 47, ss.570 - 576, 2017.
ISNAD	Utku, Burkay vd. "Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma". Turkish Journal of Medical Sciences 47/2 (2017), 570-576.