Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Objectives: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS).Patients and methods: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel automated method.Results: Serum disulphide levels were 14.7±3.4 µmol/L and 22.2±3.6 µmol/L in the FMS and control groups, respectively (p<0.001). Native thiol levels were 452.1±33.8 µmol/L and 433.5±37.6 µmol/L in the FMS and control groups, (p=0.015), while total thiol levels were 481.7±35.6 µmol/L and 477.5±38.9 µmol/L in the FMS and control groups, respectively (p=0.593). In the FMS group, disulphide/native thiol percent ratios and disulphide/total thiol percent ratios were statistically significantly lower and native/total thiol percent ratios were statistically significantly higher than those of the control group. There were no correlations between serum thiol/disulphide profiles and pain scores & clinical variables in patients with FMS.Conclusion: Because of the decreased disulphide and increased native thiol levels, the thiol/disulphide balance has shifted to the reductive side. This metabolic disturbance may have a role in the pathogenesis of FMS

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. de Araújo TA, Mota MC, Crispim CA. Obesity and sleepiness in women with fibromyalgia. Rheumatol Int 2015;35:281-7.
2. Akbas A, Inanir A, Benli I, Onder Y, Aydogan L. Evaluation of some antioxidant enzyme activities (SOD and GPX) and their polymorphisms (MnSOD2 Ala9Val, GPX1 Pro198Leu) in fibromyalgia. Eur Rev Med Pharmacol Sci 2014;18:1199-203.
3. Wolfe F, Brähler E, Hinz A, Häuser W. Fibromyalgia prevalence, somatic symptom reporting, and the dimensionality of polysymptomatic distress: results from a survey of the general population. Arthritis Care Res (Hoboken) 2013;65:777-85.
4. Tutoglu A, Boyaci A, Koca I, Celen E, Korkmaz N. Quality of life, depression, and sexual dysfunction in spouses of female patients with fibromyalgia. Rheumatol Int 2014;34:1079-84.
5. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, et al. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat 2012;2012:426130.
6. Bradley LA. Pathophysiology of fibromyalgia. Am J Med 2009;122:22-30.
7. Fatima G, Das SK, Mahdi AA. Oxidative stress and antioxidative parameters and metal ion content in patients with fibromyalgia syndrome: implications in the pathogenesis of the disease. Clin Exp Rheumatol 2013;31:128-33.
8. La Rubia M, Rus A, Molina F, Del Moral ML. Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status? Clin Exp Rheumatol 2013;31:121-7.
9. Neyal M, Yimenicioglu F, Aydeniz A, Taskin A, Saglam S, Cekmen M, et al. Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia. Clin Neurol Neurosurg 2013;115:736-40.
10. Bozkurt M, Caglayan M, Oktayoglu P, Em S, Batmaz I, Sariyildiz MA, et al. Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia. Redox Rep 2014;19:148-53.
11. Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000;72:653-69.
12. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med 2013;65:244-53.
13. Cremers CM, Jakob U. Oxidant sensing by reversible disulfide bond formation. J Biol Chem 2013;288:26489-96.
14. Jones DP, Liang Y. Measuring the poise of thiol/ disulfide couples in vivo. Free Radic Biol Med 2009;47:1329-38.
15. Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 2006;71:551-64.
16. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;48:749-62.
17. Matteucci E, Giampietro O. Thiol signalling network with an eye to diabetes. Molecules 2010;15:8890- 903.
18. Go YM, Jones DP. Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med 2011;50:495-509.
19. Prabhu A, Sarcar B, Kahali S, Yuan Z, Johnson JJ, Adam KP, et al. Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth. Cancer Res 2014;74:787-96.
20. Rodrigues SD, Batista GB, Ingberman M, Pecoits-Filho R, Nakao LS. Plasma cysteine/cystine reduction potential correlates with plasma creatinine levels in chronic kidney disease. Blood Purif 2012;34:231-7.
21. Tetik S, Ahmad S, Alturfan AA, Fresko I, Disbudak M, Sahin Y, et al. Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarthritis patients. Indian J Biochem Biophys 2010;47:353-8.
22. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160-72.
23. Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol 1991;18:728-33.
24. Sarmer S, Ergin S, Yavuzer G. The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int 2000;20:9-12.
25. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32.
26. Chianeh YR, Prabhu K. Protein thiols as an indication of oxidative stress. Archives Medical Review Journal 2014;23:443-56.
27. Sies H. Strategies of antioxidant defense. Eur J Biochem 1993;215:213-9.
28. Schwenke DC. Antioxidants and atherogenesis. J Nutr Biochem 1998;9:424-45.
29. Sendur OF, Turan Y, Tastaban E, Yenisey C, Serter M. Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study. Rheumatol Int 2009;29:629-33.
30. Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, et al. Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 2005;25:188-90.
31. Altindag O, Celik H. Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep 2006;11:131-5.
32. Altindag O, Gur A, Calgan N, Soran N, Celik H, Selek S. Paraoxonase and arylesterase activities in fibromyalgia. Redox Rep 2007;12:134-8.
33. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, et al. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol 2009;28:435-8.
34. Sarıfakıo¤lu B, Güzelant AY, Güzel EC, Güzel S, Kızıler AR. Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients. Rheumatol Int 2014;34:1361-7.
35. Richard EH, Kahn K. Current Advances in understanding the pathophysiology of Fibromyalgia. 71st annual meeting. November 06-11, 2007; Boston, Massachusetts, USA: American College of Rheumatology; 2007.
36. Dirican N, Dirican A, Sen O, Aynali A, Atalay S, Bircan HA, et al. Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer? Redox Rep 2016;21:197- 203.
37. Turkyilmaz E, Yildirim M, Cendek BD, Baran P, Alisik M, Dalgaci F, et al. Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis. Eur J Obstet Gynecol Reprod Biol 2016;199:164-8.
38. Yuksel M, Ates I, Kaplan M, Alıık M, Erel Ö, Saygılı F, et al. The dynamic thiol/disulphide homeostasis in inflammatory bowel disease and its relation with disease activity and pathogenesis. Int J Colorectal Dis 2016;31:1229-31.

APA	FIDAN F, ALKAN B, UĞURLU F, Bozkurt S, SEZER N, Bicer C, EREL O, ARDIÇOĞLU Ö, AKKUŞ S (2017). Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. , 112 - 117.
Chicago	FIDAN FATMA,ALKAN Berat Meryem,UĞURLU Fatma Gülçin,Bozkurt Sinem,SEZER NEBAHAT,Bicer Cemile,EREL Ozcan,ARDIÇOĞLU Özge,AKKUŞ Selami Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. (2017): 112 - 117.
MLA	FIDAN FATMA,ALKAN Berat Meryem,UĞURLU Fatma Gülçin,Bozkurt Sinem,SEZER NEBAHAT,Bicer Cemile,EREL Ozcan,ARDIÇOĞLU Özge,AKKUŞ Selami Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. , 2017, ss.112 - 117.
AMA	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. . 2017; 112 - 117.
Vancouver	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. . 2017; 112 - 117.
IEEE	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S "Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia." , ss.112 - 117, 2017.
ISNAD	FIDAN, FATMA vd. "Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia". (2017), 112-117.

APA	FIDAN F, ALKAN B, UĞURLU F, Bozkurt S, SEZER N, Bicer C, EREL O, ARDIÇOĞLU Ö, AKKUŞ S (2017). Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of Rheumatology, 32(2), 112 - 117.
Chicago	FIDAN FATMA,ALKAN Berat Meryem,UĞURLU Fatma Gülçin,Bozkurt Sinem,SEZER NEBAHAT,Bicer Cemile,EREL Ozcan,ARDIÇOĞLU Özge,AKKUŞ Selami Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of Rheumatology 32, no.2 (2017): 112 - 117.
MLA	FIDAN FATMA,ALKAN Berat Meryem,UĞURLU Fatma Gülçin,Bozkurt Sinem,SEZER NEBAHAT,Bicer Cemile,EREL Ozcan,ARDIÇOĞLU Özge,AKKUŞ Selami Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of Rheumatology, vol.32, no.2, 2017, ss.112 - 117.
AMA	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of Rheumatology. 2017; 32(2): 112 - 117.
Vancouver	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia. Archives of Rheumatology. 2017; 32(2): 112 - 117.
IEEE	FIDAN F,ALKAN B,UĞURLU F,Bozkurt S,SEZER N,Bicer C,EREL O,ARDIÇOĞLU Ö,AKKUŞ S "Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia." Archives of Rheumatology, 32, ss.112 - 117, 2017.
ISNAD	FIDAN, FATMA vd. "Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia". Archives of Rheumatology 32/2 (2017), 112-117.