Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities

GİRGENÇ, Merve; TURAN-ZITOUNI, Gülhan; TEBBANI, Dahmane; TABBI, Aouatef; ATLI, Özlem; KAPLANCIKLI, ZAFER ASIM; Yurttaş, Leyla; CANTÜRK, ZERRİN

Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities

Aouatef TABBI, (Department of Chemistry, Faculty of Sciences, Mentouri University, Constantin, Algeria)

Zafer Asım KAPLANCIKLI, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Bölümü, Eskişehir, Türkiye)

Dahmane TEBBANI, (Department of Chemistry, Faculty of Sciences, Mentouri University, Constantin, Algeria)

Leyla YURTTAŞ, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Bölümü, Eskişehir, Türkiye)

Zerrin CANTÜRK, (Anadolu Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalı, Eskişehir, Türkiye)

Özlem ATLI, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı Eskişehir Türkiye)

Merve BAYSAL, (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı Eskişehir Türkiye)

Gülhan TURAN-ZITOUNI (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Bölümü, Eskişehir, Türkiye)

Turkish Journal of Chemistry

2 0

Yıl: 2016 Cilt: 40 Sayı: 4 Sayfa Aralığı: 641 - 654 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities

Öz:

Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C NMR, and MS spectral data. Their antimicrobial activities againstStaphylococcus aureus(ATCC-25923),En-terococcus faecalis(ATCC-29212),Enterococcus faecalis(ATCC-51922),Listeria monocytogenes(ATCC-1911),Klebsiellapneumoniae(ATCC-700603),Pseudomonas aeruginosa(ATCC-27853),Escherichia coli(ATCC-35218),Escherichia coli(ATCC-25922),Candida albicans(ATCC-90028),Candida glabrata(ATCC-90030),Candida krusei(ATCC-6258), andCandida parapsilosis(ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects usinga MTT assay. Compound7cshowed the highest antimicrobial activity, possessing the same potential as chloramphenicolagainstK. pneumonia,P. aeruginosa, andE. coli(ATCC-25923).

Anahtar Kelime:

Konular: Mühendislik, Kimya

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	TABBI A, KAPLANCIKLI Z, TEBBANI D, Yurttaş L, CANTÜRK Z, ATLI Ö, GİRGENÇ M, TURAN-ZITOUNI G (2016). Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. , 641 - 654.
Chicago	TABBI Aouatef,KAPLANCIKLI ZAFER ASIM,TEBBANI Dahmane,Yurttaş Leyla,CANTÜRK ZERRİN,ATLI Özlem,GİRGENÇ Merve,TURAN-ZITOUNI Gülhan Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. (2016): 641 - 654.
MLA	TABBI Aouatef,KAPLANCIKLI ZAFER ASIM,TEBBANI Dahmane,Yurttaş Leyla,CANTÜRK ZERRİN,ATLI Özlem,GİRGENÇ Merve,TURAN-ZITOUNI Gülhan Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. , 2016, ss.641 - 654.
AMA	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. . 2016; 641 - 654.
Vancouver	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. . 2016; 641 - 654.
IEEE	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G "Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities." , ss.641 - 654, 2016.
ISNAD	TABBI, Aouatef vd. "Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities". (2016), 641-654.

APA	TABBI A, KAPLANCIKLI Z, TEBBANI D, Yurttaş L, CANTÜRK Z, ATLI Ö, GİRGENÇ M, TURAN-ZITOUNI G (2016). Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. Turkish Journal of Chemistry, 40(4), 641 - 654.
Chicago	TABBI Aouatef,KAPLANCIKLI ZAFER ASIM,TEBBANI Dahmane,Yurttaş Leyla,CANTÜRK ZERRİN,ATLI Özlem,GİRGENÇ Merve,TURAN-ZITOUNI Gülhan Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. Turkish Journal of Chemistry 40, no.4 (2016): 641 - 654.
MLA	TABBI Aouatef,KAPLANCIKLI ZAFER ASIM,TEBBANI Dahmane,Yurttaş Leyla,CANTÜRK ZERRİN,ATLI Özlem,GİRGENÇ Merve,TURAN-ZITOUNI Gülhan Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. Turkish Journal of Chemistry, vol.40, no.4, 2016, ss.641 - 654.
AMA	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. Turkish Journal of Chemistry. 2016; 40(4): 641 - 654.
Vancouver	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities. Turkish Journal of Chemistry. 2016; 40(4): 641 - 654.
IEEE	TABBI A,KAPLANCIKLI Z,TEBBANI D,Yurttaş L,CANTÜRK Z,ATLI Ö,GİRGENÇ M,TURAN-ZITOUNI G "Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities." Turkish Journal of Chemistry, 40, ss.641 - 654, 2016.
ISNAD	TABBI, Aouatef vd. "Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities". Turkish Journal of Chemistry 40/4 (2016), 641-654.