TY  - JOUR
TI  - Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities
AB  - Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C NMR, and MS spectral data. Their antimicrobial activities againstStaphylococcus aureus(ATCC-25923),En-terococcus faecalis(ATCC-29212),Enterococcus faecalis(ATCC-51922),Listeria monocytogenes(ATCC-1911),Klebsiellapneumoniae(ATCC-700603),Pseudomonas aeruginosa(ATCC-27853),Escherichia coli(ATCC-35218),Escherichia coli(ATCC-25922),Candida albicans(ATCC-90028),Candida glabrata(ATCC-90030),Candida krusei(ATCC-6258), andCandida parapsilosis(ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects usinga MTT assay. Compound7cshowed the highest antimicrobial activity, possessing the same potential as chloramphenicolagainstK. pneumonia,P. aeruginosa, andE. coli(ATCC-25923).
AU  - GİRGENÇ, Merve
AU  - TURAN-ZITOUNI, Gülhan
AU  - TEBBANI, Dahmane
AU  - TABBI, Aouatef
AU  - ATLI, Özlem
AU  - KAPLANCIKLI, ZAFER ASIM
AU  - Yurttaş, Leyla
AU  - CANTÜRK, ZERRİN
PY  - 2016
JO  - Turkish Journal of Chemistry
VL  - 40
IS  - 4
SN  - 1300-0527
SP  - 641
EP  - 654
DB  - TRDizin
UR  - http://search/yayin/detay/256126
ER  -