TY  - JOUR
TI  - Endocan Measurement for Active Behçet Disease
AB  - Objectives: This study aims to investigate the relationships between serum endocan, vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-?) levels in active Behçet disease.Patients and methods: Forty patients with active Behçet disease (24 males, 16 females; mean age 37.6±8.7 years; range 20 to 50 years) and 40 healthy controls (22 males, 18 females; mean age 38.8±7.9 years; range 21 to 52 years) were included in this study. Both patient and control groups underwent a complete systemic and ophthalmic examination by the same specialist. Endocan, VEGF, and TNF-? levels were measured with an enzyme-linked immunosorbent assay kit in all subjects.Results: Serum endocan levels were 775.2±479.3 ng/mL and 275.8±145.8 ng/mL in the patient and control groups, respectively. VEGF levels were 1768.2±900.5 pg/mL and 980.2±135.3 pg/mL in the patient and control groups, respectively. TNF-? levels were 22.4±74.3 pg/mL-1 and 11.4±16.9 pg/mL-1 in the patient and control groups, respectively. There was a statistically significant difference between groups in terms of serum endocan, VEGF, and TNF-? levels. There was a significant positive correlation between serum endocan and VEGF levels in the patient group (r=0.630; p<0.001). Also, there was a significant positive correlation between serum endocan and TNF-? levels in the patient group (r=0.713; p<0.001).Conclusion: Serum endocan level may be a new marker in evaluation of both the prognosis and activity of Behçet disease.
AU  - ATEŞ, Orhan
AU  - Alkan Melikoglu, Meltem
AU  - KUL, Ayhan
AU  - ÖZTÜRK, Nurinnisa
AU  - ERKAYHAN, Gülsüm
AU  - KOÇER, İbrahim
AU  - UĞUR, Mahir
PY  - 2017
JO  - Archives of Rheumatology
VL  - 32
IS  - 3
SN  - 2148-5046
SP  - 197
EP  - 202
DB  - TRDizin
UR  - http://search/yayin/detay/256238
ER  -