Yıl: 2017 Cilt: 32 Sayı: 3 Sayfa Aralığı: 203 - 208 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients

Öz:
Objectives: This study aims to evaluate tryptophan degradation and clarify whether altered levels of kynurenine and tryptophan (Kyn/Trp) ratio could be correlated to osteoporotic hip fractures via immune system.Patients and methods: The study included 60 patients with osteoporotic hip fracture (20 males, 40 females, mean age 76.6±6.9 years; range 59 to 95 years). Patients were divided into two as patients with collum femoris fractures (group 1; n=23) and intertrochanteric fractures (group 2; n=37). Fifteen healthy subjects without any fracture were selected as control group (group 3; 3 males, 12 females; mean age 69.7±8.4; range 60 to 86 years). All fractures were simple falls due to low energy trauma. Bone mineral density measurements were performed with Lunar dual energy X-ray absorptiometry. Kyn/Trp levels were measured by high performance liquid chromatography. Interleukin (IL)-6 and IL-1 beta levels were measured with solid-phase sandwich enzyme-linked immunosorbent assay.Results: All bone mineral density values were in agreement for osteoporosis and there was no significant difference between the two groups. Higher Kyn/Trp ratios were observed in groups 1 and 2 compared to group 3. This difference was more significant in group 1 (p=0.0001) than that in group 2 (p=0.048). Also, group 1 had significantly higher Kyn/Trp ratio than group 2 (p=0.011). There were significantly higher IL-6 and lower IL-1 beta levels both in groups 1 and 2 compared to group 3 (p=0.0001). There was no significant difference between group 1 and group 2 in terms of IL-6 and IL-1 beta levels. There was positive correlation with Kyn/Trp ratio (r=0.581, p=0.004) in group 2. Also, significant correlation was detected between IL-6 and IL-1 beta levels in the same group (r=0.665, p=0.036).Conclusion: Both increased degradation of tryptophan and ratio of Kyn/Trp indicate the relationship of immune activation with bone healing.
Anahtar Kelime:

Konular: Romatoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA DİNÇEL E, ÖZKAN Y, ŞÜKÜROĞLU M, Ozsoy M, DİNÇEL SEPİCİ A (2017). Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. , 203 - 208.
Chicago DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. (2017): 203 - 208.
MLA DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. , 2017, ss.203 - 208.
AMA DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. . 2017; 203 - 208.
Vancouver DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. . 2017; 203 - 208.
IEEE DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients." , ss.203 - 208, 2017.
ISNAD DİNÇEL, Ercan vd. "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients". (2017), 203-208.
APA DİNÇEL E, ÖZKAN Y, ŞÜKÜROĞLU M, Ozsoy M, DİNÇEL SEPİCİ A (2017). Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology, 32(3), 203 - 208.
Chicago DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology 32, no.3 (2017): 203 - 208.
MLA DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology, vol.32, no.3, 2017, ss.203 - 208.
AMA DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology. 2017; 32(3): 203 - 208.
Vancouver DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology. 2017; 32(3): 203 - 208.
IEEE DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients." Archives of Rheumatology, 32, ss.203 - 208, 2017.
ISNAD DİNÇEL, Ercan vd. "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients". Archives of Rheumatology 32/3 (2017), 203-208.