Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients

ÖZKAN, YEŞİM; DİNÇEL SEPİCİ, Aylin; Ozsoy, Mehmet Hakan; DİNÇEL, Ercan; ŞÜKÜROĞLU, MURAT KADİR

Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients

Ercan DİNÇEL, (Department of Orthopedics and Traumatology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey)

Yeşim ÖZKAN, (Department of Biochemistry, University of Gazi, Faculty of Pharmacy, Ankara, Turkey)

MURAT KADİR ŞÜKÜROĞLU, (Department of Pharmaceutical Chemistry, University of Gazi, Faculty of Pharmacy, Ankara, Turkey)

Hakan ÖZSOY, (Department of Orthopedics and Traumatology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey)

Aylin DİNÇEL SEPİCİ (Department of Medical Biochemistry, University of Gazi, Faculty of Medicine, Ankara, Turkey)

Archives of Rheumatology

1 0

Yıl: 2017 Cilt: 32 Sayı: 3 Sayfa Aralığı: 203 - 208 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients

Öz:

Objectives: This study aims to evaluate tryptophan degradation and clarify whether altered levels of kynurenine and tryptophan (Kyn/Trp) ratio could be correlated to osteoporotic hip fractures via immune system.Patients and methods: The study included 60 patients with osteoporotic hip fracture (20 males, 40 females, mean age 76.6±6.9 years; range 59 to 95 years). Patients were divided into two as patients with collum femoris fractures (group 1; n=23) and intertrochanteric fractures (group 2; n=37). Fifteen healthy subjects without any fracture were selected as control group (group 3; 3 males, 12 females; mean age 69.7±8.4; range 60 to 86 years). All fractures were simple falls due to low energy trauma. Bone mineral density measurements were performed with Lunar dual energy X-ray absorptiometry. Kyn/Trp levels were measured by high performance liquid chromatography. Interleukin (IL)-6 and IL-1 beta levels were measured with solid-phase sandwich enzyme-linked immunosorbent assay.Results: All bone mineral density values were in agreement for osteoporosis and there was no significant difference between the two groups. Higher Kyn/Trp ratios were observed in groups 1 and 2 compared to group 3. This difference was more significant in group 1 (p=0.0001) than that in group 2 (p=0.048). Also, group 1 had significantly higher Kyn/Trp ratio than group 2 (p=0.011). There were significantly higher IL-6 and lower IL-1 beta levels both in groups 1 and 2 compared to group 3 (p=0.0001). There was no significant difference between group 1 and group 2 in terms of IL-6 and IL-1 beta levels. There was positive correlation with Kyn/Trp ratio (r=0.581, p=0.004) in group 2. Also, significant correlation was detected between IL-6 and IL-1 beta levels in the same group (r=0.665, p=0.036).Conclusion: Both increased degradation of tryptophan and ratio of Kyn/Trp indicate the relationship of immune activation with bone healing.

Anahtar Kelime:

Konular: Romatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DİNÇEL E, ÖZKAN Y, ŞÜKÜROĞLU M, Ozsoy M, DİNÇEL SEPİCİ A (2017). Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. , 203 - 208.
Chicago	DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. (2017): 203 - 208.
MLA	DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. , 2017, ss.203 - 208.
AMA	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. . 2017; 203 - 208.
Vancouver	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. . 2017; 203 - 208.
IEEE	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients." , ss.203 - 208, 2017.
ISNAD	DİNÇEL, Ercan vd. "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients". (2017), 203-208.

APA	DİNÇEL E, ÖZKAN Y, ŞÜKÜROĞLU M, Ozsoy M, DİNÇEL SEPİCİ A (2017). Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology, 32(3), 203 - 208.
Chicago	DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology 32, no.3 (2017): 203 - 208.
MLA	DİNÇEL Ercan,ÖZKAN YEŞİM,ŞÜKÜROĞLU MURAT KADİR,Ozsoy Mehmet Hakan,DİNÇEL SEPİCİ Aylin Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology, vol.32, no.3, 2017, ss.203 - 208.
AMA	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology. 2017; 32(3): 203 - 208.
Vancouver	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients. Archives of Rheumatology. 2017; 32(3): 203 - 208.
IEEE	DİNÇEL E,ÖZKAN Y,ŞÜKÜROĞLU M,Ozsoy M,DİNÇEL SEPİCİ A "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients." Archives of Rheumatology, 32, ss.203 - 208, 2017.
ISNAD	DİNÇEL, Ercan vd. "Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients". Archives of Rheumatology 32/3 (2017), 203-208.