Truffle mushrooms are known to be a valuable food product for centuries, especially in France and Italy, which grow in soil and have high economic value. It grows up naturally in our country that including the Mediterranean climate zone. In our country, studies on truffle mushrooms have gained speed in recent years. Truffle mushrooms bring the ectomycorrhizal partnership with the roots of trees like oak, hazelnut, pine and linden. With truffle mushroom, the plant enters into a beneficial relationship with each other by symbiotic life. In this respect, mycorrhizae formation and truffle mushroom cultivation are carried out in the roots of these plants (hazelnut, oak) and supplementary nutrients that plant roots can't reach with the help of hyphae in the mantel. Truffle mushrooms are naturally found in several provinces especially Denizli, Muğla, Aydın, Antalya and Burdur provinces. Studies have been initiated in our country on vaccination of osprey species in the Aegean region. It is important that the truffle mushroom grows in limited geographical areas and finds recipients at very high prices and it is important for our country to increase its work, to increase the work done in this area, to determine natural aquaculture areas, to cultivate and to continue to work further. In this context, our country supplied 75% of the world hazelnut production and it will be contributed to a separate income and product variety for hazelnut areas with this plant inoculation of truffle species.