Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS

KAYMAK, EMİN; SÖNMEZ, Mehmet Fatih; KARABULUT, DERYA; ULUSOY, Hasan Basri

Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS

Derya KARABULUT, (Departments of Histology and Embryology and *Pharmacology, Faculty of Medicine, Erciyes University; Kayseri-Turkey)

Hasan Basri ULUSOY, (Departments of Histology and Embryology and *Pharmacology, Faculty of Medicine, Erciyes University; Kayseri-Turkey)

Emin KAYMAK, (Departments of Histology and Embryology and *Pharmacology, Faculty of Medicine, Erciyes University; Kayseri-Turkey)

Mehmet Fatih SÖNMEZ (Departments of Histology and Embryology and *Pharmacology, Faculty of Medicine, Erciyes University; Kayseri-Turkey)

The Anatolian Journal of Cardiology

3 0

Yıl: 2016 Cilt: 16 Sayı: 5 Sayfa Aralığı: 310 - 315 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS

Öz:

Objective: Diabetes mellitus causes a decrease in cardiac output, arterial blood pressure, and heart rate. In this study, we aimed to investigate, at the molecular level, the effect of nitric oxide synthase (NOS) on heart pathology in type 1 diabetes and look at the therapeutic effect of pentoxifylline on this pathology.Methods: In this experimental study, 50 Wistar albino male rats were used. The rats were divided into 5 groups: group C, control; group D, only diabetes; group D+PI and D+PII, diabetes + pentoxifylline; group P, only pentoxifylline. Group D+PI rats received 50 mg/kg/day pentoxifylline over two months. However, group D+PII rats received saline in the first month and 50 mg/kg/day of pentoxifylline over the following month. At the end of two months, NOS expressions in heart tissue were assessed through immunohistochemistry analysis. The data were compared by one-way ANOVA.Results: At the end of the experiments, there was increased cytoplasmic vacuolization, myofibrillar loss, cytoplasmic eosinophilia, and degeneration of cardiomyocytes; nNOS and iNOS expressions in group D decreased compared with that in group C. In group D+PI and group D+PII, nNOS and iNOS expressions improved compared with group D.Conclusion: As a result, we found that diabetes, a known chronic disease, causes serious damage in heart tissue. NOS plays a role in this damage, and pentoxifylline aided in improving nNOS and iNOS expression in this damage.

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Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARABULUT D, ULUSOY H, KAYMAK E, SÖNMEZ M (2016). Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. , 310 - 315.
Chicago	KARABULUT DERYA,ULUSOY Hasan Basri,KAYMAK EMİN,SÖNMEZ Mehmet Fatih Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. (2016): 310 - 315.
MLA	KARABULUT DERYA,ULUSOY Hasan Basri,KAYMAK EMİN,SÖNMEZ Mehmet Fatih Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. , 2016, ss.310 - 315.
AMA	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. . 2016; 310 - 315.
Vancouver	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. . 2016; 310 - 315.
IEEE	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M "Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS." , ss.310 - 315, 2016.
ISNAD	KARABULUT, DERYA vd. "Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS". (2016), 310-315.

APA	KARABULUT D, ULUSOY H, KAYMAK E, SÖNMEZ M (2016). Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. The Anatolian Journal of Cardiology, 16(5), 310 - 315.
Chicago	KARABULUT DERYA,ULUSOY Hasan Basri,KAYMAK EMİN,SÖNMEZ Mehmet Fatih Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. The Anatolian Journal of Cardiology 16, no.5 (2016): 310 - 315.
MLA	KARABULUT DERYA,ULUSOY Hasan Basri,KAYMAK EMİN,SÖNMEZ Mehmet Fatih Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. The Anatolian Journal of Cardiology, vol.16, no.5, 2016, ss.310 - 315.
AMA	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. The Anatolian Journal of Cardiology. 2016; 16(5): 310 - 315.
Vancouver	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS. The Anatolian Journal of Cardiology. 2016; 16(5): 310 - 315.
IEEE	KARABULUT D,ULUSOY H,KAYMAK E,SÖNMEZ M "Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS." The Anatolian Journal of Cardiology, 16, ss.310 - 315, 2016.
ISNAD	KARABULUT, DERYA vd. "Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS". The Anatolian Journal of Cardiology 16/5 (2016), 310-315.